| Título : |
Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study |
| Tipo de documento : |
documento electrónico |
| Autores : |
Sergio Iván Hoyos Duque, ; Carlos Ernesto Guzmán Luna, ; Álvaro Mena Hurtado, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Juan Camilo Pérez Cadavid, |
| Fecha de publicación : |
2015 |
| Títulos uniformes : |
Annals of Hepatology
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
Cancer liver transplant cirrhosis biopsy |
| Resumen : |
Introduction: Hepatocellular carcinoma is the most common primary tumor of the liver and is diagnosed in more than a half million people worldwide each year. This study aims to assess factors associated with the recurrence and survival of patients with hepatocellular carcinoma and liver transplantation in a cohort of patients from Medellín, Colombia. Material and methods. This was a descriptive retrospective study of a consecutive series of liver transplant patients from the Pablo Tobon Uribe Hospital of Medellín from January 2004 to May 2013. Demographic, clinical, imaging, and pathology variables were analyzed. Results: Three hundred thirty liver transplants were performed during the study period, 54 cases (16.4%) had one or more hepatocellular carcinomas in the explant, and 79.6% of these patients were men. Cirrhotic patients had different etiologies, but most of them were due to alcohol abuse (22.2%), followed by hepatitis B virus infection (20.4 %), and hepatitis C virus infection (18.5%). In the pathology specimen, 51.9% had only one focus of hepatocellular carcinoma, 22.2% had two foci and 12.9% had three tumors. Recurrence of hepatocellular carcinoma occurred in 7.4% patients with an average time of 81 months. During follow-up, 25.9% of the patients died in an average time of 67.9 months (CI95 59.1-80.1 months). Conclusion: Recurrence and survival of patients with liver transplantation for hepatocellular carcinoma in this study had a similar behavior as that reported in the world literature. The factors associated with these outcomes were vascular invasion, poor tumor differentiation and satellitosis. |
| Mención de responsabilidad : |
Sergio Hoyos, Jorge Escobar, Doris Cardona, Carlos Guzmán, Álvaro Mena, Germán Osorio, Camilo Pérez, Juan C Restrepo, Gonzalo Correa |
| Referencia : |
Ann Hepatol. 2015 Jan-Feb;14(1):58-63. |
| PMID : |
25536642 |
| En línea : |
https://linkinghub.elsevier.com/retrieve/pii/S1665268119308014 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study [documento electrónico] / Sergio Iván Hoyos Duque, ; Carlos Ernesto Guzmán Luna, ; Álvaro Mena Hurtado, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Juan Camilo Pérez Cadavid, . - 2015. Obra : Annals of HepatologyIdioma : Inglés ( eng)
| Palabras clave : |
Cancer liver transplant cirrhosis biopsy |
| Resumen : |
Introduction: Hepatocellular carcinoma is the most common primary tumor of the liver and is diagnosed in more than a half million people worldwide each year. This study aims to assess factors associated with the recurrence and survival of patients with hepatocellular carcinoma and liver transplantation in a cohort of patients from Medellín, Colombia. Material and methods. This was a descriptive retrospective study of a consecutive series of liver transplant patients from the Pablo Tobon Uribe Hospital of Medellín from January 2004 to May 2013. Demographic, clinical, imaging, and pathology variables were analyzed. Results: Three hundred thirty liver transplants were performed during the study period, 54 cases (16.4%) had one or more hepatocellular carcinomas in the explant, and 79.6% of these patients were men. Cirrhotic patients had different etiologies, but most of them were due to alcohol abuse (22.2%), followed by hepatitis B virus infection (20.4 %), and hepatitis C virus infection (18.5%). In the pathology specimen, 51.9% had only one focus of hepatocellular carcinoma, 22.2% had two foci and 12.9% had three tumors. Recurrence of hepatocellular carcinoma occurred in 7.4% patients with an average time of 81 months. During follow-up, 25.9% of the patients died in an average time of 67.9 months (CI95 59.1-80.1 months). Conclusion: Recurrence and survival of patients with liver transplantation for hepatocellular carcinoma in this study had a similar behavior as that reported in the world literature. The factors associated with these outcomes were vascular invasion, poor tumor differentiation and satellitosis. |
| Mención de responsabilidad : |
Sergio Hoyos, Jorge Escobar, Doris Cardona, Carlos Guzmán, Álvaro Mena, Germán Osorio, Camilo Pérez, Juan C Restrepo, Gonzalo Correa |
| Referencia : |
Ann Hepatol. 2015 Jan-Feb;14(1):58-63. |
| PMID : |
25536642 |
| En línea : |
https://linkinghub.elsevier.com/retrieve/pii/S1665268119308014 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study
