Treatment of invasive silent somatotroph pituitary adenoma with temozolomide. Report of a case and review of the literature [documento electrónico] / Luis Vicente Syro Moreno,  . - 2015.
Obra : Endocrine Pathology

Idioma : Inglés (eng)

Palabras clave :	MGMT  pathology  pituitary  somatotroph adenoma  temozolomide
Resumen :	Improved imaging techniques have contributed to increased diagnosis of pituitary tumors. These tumor types can be microadenomas or macroadenomas and can either be functional or non-functional. Atypical or aggressive pituitary adenomas are tumors that rapidly increase in size and may invade into the suprasellar or parasellar regions. They are characterized by a Ki-67 nuclear labeling index greater than 10 %. Management of these tumors is difficult, and many recur after surgery. Temozolomide, a second generation alkylating agent, has been showing promising results in the treatment of these tumors. The patient was a 39-year-old male diagnosed with an invasive silent somatotroph pituitary macroadenoma treated with temozolomide after surgery. We present the case along with the review of the literature of the therapeutic effects of temozolomide in somatotroph macroadenomas.
Mención de responsabilidad :	Ali A Ghazi, Fabio Rotondo, Kalman Kovacs, Alireza Amirbaigloo, Luis V Syro, Hussein Fathalla, Antonio Di Ieva, Michael D Cusimano
Referencia :	Endocr Pathol. 2015 May;26(2):135-9.
DOI (Digital Object Identifier) :	10.1007/s12022-015-9361-z
PMID :	25716461
En línea :	https://link.springer.com/article/10.1007%2Fs12022-015-9361-z
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3882