Inicio
Autor Alejandro Díaz Díaz
|
Comentario :
Médico Pediatra, Hospital Pablo Tobón Uribe
|
Documentos disponibles escritos por este autor (2)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaCMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia / Laura Fernanda Niño Serna ; Alejandro Díaz Díaz ; Mónica Rosa Trujillo Honeysberg ; Natalia Builes R. ; Arias, Andrés ; Aristizábal, Beatriz H
Título : CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, Autor ; Alejandro Díaz Díaz, Autor ; Mónica Rosa Trujillo Honeysberg, Autor ; Natalia Builes R., Autor ; Arias, Andrés, Autor ; Aristizábal, Beatriz H, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Transplantation Idioma : Inglés (eng) Palabras clave : CMV; cytomegalovirus infection; haploidentical; hematopoietic stem cell transplantation; pediatrics; transplantation Resumen : Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform. This study aimed to describe the incidence, clinical characteristics, and evolution of children with CMV reactivation after HSCT and the possible impact of unmanipulated stem cells with PTCy for GvHD prophylaxis. Methods: Retrospective cohort study of children undergoing hematopoietic stem cell transplantation from January 2012 to June 2022. Baseline characteristics and the clinical course were described. Duration of treatment, initial viral load, and time to clearance of DNAemia by type of transplant were compared using the Kruskal-Wallis test. Survival analysis was performed with the Kaplan–Meier method and log-rank test. All statistical analysis was performed using SPSS software, version 20.0. Results: One hundred sixty-six children were included. Among them, 87% of recipients and 88% of donors were CMV positive. The cumulative incidence of cytomegalovirus DNAemia was 28% at 100 days post-transplantation. There were no differences between different donor types. Overall survival at 1 year was 60%, and non-relapse mortality was observed in 28%. CMV reactivation did not appear to negatively impact 1-year overall survival (OS). Conclusions: Our study found no differences in CMV reactivation rates, treatment duration, viral clearance times, co-infections, or 1-year overall survival across different HSCT donor types. Studies are needed to establish more precise criteria for monitoring recipients, particularly in regions where unmanipulated stem cells with PTCy for GvHD prophylaxis are increasing. © 2025 Wiley Periodicals LLC. Mención de responsabilidad : Arias, Andres, Builes, Natalia, Niño-Serna, Laura, Diaz, Alejandro, Aristizabal, Beatriz H., Trujillo, Monica. Referencia : Pediatr Transplant . 2025 Feb;29(1):e70033 DOI (Digital Object Identifier) : 10.1111/petr.70033 PMID : 39837777 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39837777/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia [documento electrónico] / Laura Fernanda Niño Serna, Autor ; Alejandro Díaz Díaz, Autor ; Mónica Rosa Trujillo Honeysberg, Autor ; Natalia Builes R., Autor ; Arias, Andrés, Autor ; Aristizábal, Beatriz H, Autor . - 2025.
Obra : Pediatric Transplantation
Idioma : Inglés (eng)
Palabras clave : CMV; cytomegalovirus infection; haploidentical; hematopoietic stem cell transplantation; pediatrics; transplantation Resumen : Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform. This study aimed to describe the incidence, clinical characteristics, and evolution of children with CMV reactivation after HSCT and the possible impact of unmanipulated stem cells with PTCy for GvHD prophylaxis. Methods: Retrospective cohort study of children undergoing hematopoietic stem cell transplantation from January 2012 to June 2022. Baseline characteristics and the clinical course were described. Duration of treatment, initial viral load, and time to clearance of DNAemia by type of transplant were compared using the Kruskal-Wallis test. Survival analysis was performed with the Kaplan–Meier method and log-rank test. All statistical analysis was performed using SPSS software, version 20.0. Results: One hundred sixty-six children were included. Among them, 87% of recipients and 88% of donors were CMV positive. The cumulative incidence of cytomegalovirus DNAemia was 28% at 100 days post-transplantation. There were no differences between different donor types. Overall survival at 1 year was 60%, and non-relapse mortality was observed in 28%. CMV reactivation did not appear to negatively impact 1-year overall survival (OS). Conclusions: Our study found no differences in CMV reactivation rates, treatment duration, viral clearance times, co-infections, or 1-year overall survival across different HSCT donor types. Studies are needed to establish more precise criteria for monitoring recipients, particularly in regions where unmanipulated stem cells with PTCy for GvHD prophylaxis are increasing. © 2025 Wiley Periodicals LLC. Mención de responsabilidad : Arias, Andres, Builes, Natalia, Niño-Serna, Laura, Diaz, Alejandro, Aristizabal, Beatriz H., Trujillo, Monica. Referencia : Pediatr Transplant . 2025 Feb;29(1):e70033 DOI (Digital Object Identifier) : 10.1111/petr.70033 PMID : 39837777 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39837777/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
Reservar este documento
Ejemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002325 AC-2025-008 Archivo digital Producción Científica Artículos científicos Disponible 
Título : Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America [documento electrónico] / Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
Reservar este documento
Ejemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001862 AC-2022-028 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-028Adobe Acrobat PDF
