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Autor Alejandro Díaz Díaz
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Comentario :
Médico Pediatra, Hospital Pablo Tobón Uribe
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Documentos disponibles escritos por este autor (4)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaCMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia / Laura Fernanda Niño Serna ; Alejandro Díaz Díaz ; Mónica Rosa Trujillo Honeysberg ; Natalia Builes R. ; Arias, Andrés ; Aristizábal, Beatriz H
Título : CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, Autor ; Alejandro Díaz Díaz, Autor ; Mónica Rosa Trujillo Honeysberg, Autor ; Natalia Builes R., Autor ; Arias, Andrés, Autor ; Aristizábal, Beatriz H, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Transplantation Idioma : Inglés (eng) Palabras clave : CMV; cytomegalovirus infection; haploidentical; hematopoietic stem cell transplantation; pediatrics; transplantation Resumen : Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform. This study aimed to describe the incidence, clinical characteristics, and evolution of children with CMV reactivation after HSCT and the possible impact of unmanipulated stem cells with PTCy for GvHD prophylaxis. Methods: Retrospective cohort study of children undergoing hematopoietic stem cell transplantation from January 2012 to June 2022. Baseline characteristics and the clinical course were described. Duration of treatment, initial viral load, and time to clearance of DNAemia by type of transplant were compared using the Kruskal-Wallis test. Survival analysis was performed with the Kaplan–Meier method and log-rank test. All statistical analysis was performed using SPSS software, version 20.0. Results: One hundred sixty-six children were included. Among them, 87% of recipients and 88% of donors were CMV positive. The cumulative incidence of cytomegalovirus DNAemia was 28% at 100 days post-transplantation. There were no differences between different donor types. Overall survival at 1 year was 60%, and non-relapse mortality was observed in 28%. CMV reactivation did not appear to negatively impact 1-year overall survival (OS). Conclusions: Our study found no differences in CMV reactivation rates, treatment duration, viral clearance times, co-infections, or 1-year overall survival across different HSCT donor types. Studies are needed to establish more precise criteria for monitoring recipients, particularly in regions where unmanipulated stem cells with PTCy for GvHD prophylaxis are increasing. © 2025 Wiley Periodicals LLC. Mención de responsabilidad : Arias, Andres, Builes, Natalia, Niño-Serna, Laura, Diaz, Alejandro, Aristizabal, Beatriz H., Trujillo, Monica. Referencia : Pediatr Transplant . 2025 Feb;29(1):e70033 DOI (Digital Object Identifier) : 10.1111/petr.70033 PMID : 39837777 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39837777/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia [documento electrónico] / Laura Fernanda Niño Serna, Autor ; Alejandro Díaz Díaz, Autor ; Mónica Rosa Trujillo Honeysberg, Autor ; Natalia Builes R., Autor ; Arias, Andrés, Autor ; Aristizábal, Beatriz H, Autor . - 2025.
Obra : Pediatric Transplantation
Idioma : Inglés (eng)
Palabras clave : CMV; cytomegalovirus infection; haploidentical; hematopoietic stem cell transplantation; pediatrics; transplantation Resumen : Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform. This study aimed to describe the incidence, clinical characteristics, and evolution of children with CMV reactivation after HSCT and the possible impact of unmanipulated stem cells with PTCy for GvHD prophylaxis. Methods: Retrospective cohort study of children undergoing hematopoietic stem cell transplantation from January 2012 to June 2022. Baseline characteristics and the clinical course were described. Duration of treatment, initial viral load, and time to clearance of DNAemia by type of transplant were compared using the Kruskal-Wallis test. Survival analysis was performed with the Kaplan–Meier method and log-rank test. All statistical analysis was performed using SPSS software, version 20.0. Results: One hundred sixty-six children were included. Among them, 87% of recipients and 88% of donors were CMV positive. The cumulative incidence of cytomegalovirus DNAemia was 28% at 100 days post-transplantation. There were no differences between different donor types. Overall survival at 1 year was 60%, and non-relapse mortality was observed in 28%. CMV reactivation did not appear to negatively impact 1-year overall survival (OS). Conclusions: Our study found no differences in CMV reactivation rates, treatment duration, viral clearance times, co-infections, or 1-year overall survival across different HSCT donor types. Studies are needed to establish more precise criteria for monitoring recipients, particularly in regions where unmanipulated stem cells with PTCy for GvHD prophylaxis are increasing. © 2025 Wiley Periodicals LLC. Mención de responsabilidad : Arias, Andres, Builes, Natalia, Niño-Serna, Laura, Diaz, Alejandro, Aristizabal, Beatriz H., Trujillo, Monica. Referencia : Pediatr Transplant . 2025 Feb;29(1):e70033 DOI (Digital Object Identifier) : 10.1111/petr.70033 PMID : 39837777 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39837777/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, Autor ; Sossa Alarcón, María Camila, Autor ; Gutiérrez, Mónica Paola, Autor ; Becerra, Natalia, Autor ; Ortegon, Luz Yessenia, Autor ; David, María Camila, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Piñeros, Juan Gabriel, Autor ; Restrepo Gualteros, Sonia, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez Tobar, Iván, Autor ; Camilo Mesa, Andrés, Autor ; Bachiller Tuta, William Ricardo, Autor ; Galvis Diaz, Clara Esperanza, Autor ; Africano, Martha, Autor ; Nieto, José Manuel, Autor ; Pérez Camacho, Paola Marsela, Autor ; Beltrán Arroyave, Claudia, Autor ; Vivas Trochez, Rosalba, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Herrero, Blanca, Autor ; Calleja, Lourdes, Autor ; Grasa, Carlos, Autor ; Rodriguez, Paula, Autor ; Melendo, Susana, Autor ; Soriano Arandes, Antoni, Autor ; Gómez Pastrana, Irene, Autor ; García García, Sonsoles, Autor ; Fumado, Victoria, Autor ; Ramirez Varela, Andrea, Autor Fecha de publicación : 2025 Títulos uniformes : International Journal of Collaborative Research on Internal Medicine & Public Health Idioma : Inglés (eng) Palabras clave : COVID-19 pediatrics inpatients cluster analysis SARS-CoV-2 variants Resumen : Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. Mención de responsabilidad : María Camila Sossa-Alarcón1*†, Mónica Paola Gutiérrez1†, Natalia Becerra1†,Luz Yessenia Ortegon1†, María Camila David1†,Melisa Naranjo vanegas2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, Gabriela Friedrich 2,Pablo Vásquez-Hoyos3, María Lucía Mesa-Rubio1,Luis Miguel Navarro-Ramirez2Sergio Moreno-Lopez2, Olga Lucía Baquero4, Luz Marina Mejía5, Juan Gabriel Piñeros1,Sonia Restrepo-Gualteros1, Carlos Álvarez-Moreno6, Alejandro Díaz-Díaz7, Iván Gutierrez-Tobar8, Andrés Camilo Mesa9, William Ricardo Bachiller Tuta10,Clara Esperanza Galvis Diaz11, Martha Africano12, José Manuel Nieto13,Paola Marcela Pérez Camacho14, Claudia Beltrán-Arroyave15, Rosalba Vivas Trochez16,Irati Gastesi17, Cinta Moraleda17, Alfredo Tagarro García17,18, Blanca Herrero19,Lourdes Calleja19, Carlos Grasa20, Paula Rodriguez20, Susana Melendo21,Antoni Soriano-Arandes21, Irene Gómez Pastrana17, Sonsoles García García17,Victoria Fumado22 and Andrea Ramírez Varela23 on behalf of EPICO-Colombia and EPICO-AEP Referencia : Int J Public Health. 2025 Mar 18;70:1607246 DOI (Digital Object Identifier) : 10.3389/ijph.2025.1607246 PMID : 40170693 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11959304/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study [documento electrónico] / Alejandro Díaz Díaz, Autor ; Sossa Alarcón, María Camila, Autor ; Gutiérrez, Mónica Paola, Autor ; Becerra, Natalia, Autor ; Ortegon, Luz Yessenia, Autor ; David, María Camila, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Piñeros, Juan Gabriel, Autor ; Restrepo Gualteros, Sonia, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez Tobar, Iván, Autor ; Camilo Mesa, Andrés, Autor ; Bachiller Tuta, William Ricardo, Autor ; Galvis Diaz, Clara Esperanza, Autor ; Africano, Martha, Autor ; Nieto, José Manuel, Autor ; Pérez Camacho, Paola Marsela, Autor ; Beltrán Arroyave, Claudia, Autor ; Vivas Trochez, Rosalba, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Herrero, Blanca, Autor ; Calleja, Lourdes, Autor ; Grasa, Carlos, Autor ; Rodriguez, Paula, Autor ; Melendo, Susana, Autor ; Soriano Arandes, Antoni, Autor ; Gómez Pastrana, Irene, Autor ; García García, Sonsoles, Autor ; Fumado, Victoria, Autor ; Ramirez Varela, Andrea, Autor . - 2025.
Obra : International Journal of Collaborative Research on Internal Medicine & Public Health
Idioma : Inglés (eng)
Palabras clave : COVID-19 pediatrics inpatients cluster analysis SARS-CoV-2 variants Resumen : Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. Mención de responsabilidad : María Camila Sossa-Alarcón1*†, Mónica Paola Gutiérrez1†, Natalia Becerra1†,Luz Yessenia Ortegon1†, María Camila David1†,Melisa Naranjo vanegas2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, Gabriela Friedrich 2,Pablo Vásquez-Hoyos3, María Lucía Mesa-Rubio1,Luis Miguel Navarro-Ramirez2Sergio Moreno-Lopez2, Olga Lucía Baquero4, Luz Marina Mejía5, Juan Gabriel Piñeros1,Sonia Restrepo-Gualteros1, Carlos Álvarez-Moreno6, Alejandro Díaz-Díaz7, Iván Gutierrez-Tobar8, Andrés Camilo Mesa9, William Ricardo Bachiller Tuta10,Clara Esperanza Galvis Diaz11, Martha Africano12, José Manuel Nieto13,Paola Marcela Pérez Camacho14, Claudia Beltrán-Arroyave15, Rosalba Vivas Trochez16,Irati Gastesi17, Cinta Moraleda17, Alfredo Tagarro García17,18, Blanca Herrero19,Lourdes Calleja19, Carlos Grasa20, Paula Rodriguez20, Susana Melendo21,Antoni Soriano-Arandes21, Irene Gómez Pastrana17, Sonsoles García García17,Victoria Fumado22 and Andrea Ramírez Varela23 on behalf of EPICO-Colombia and EPICO-AEP Referencia : Int J Public Health. 2025 Mar 18;70:1607246 DOI (Digital Object Identifier) : 10.3389/ijph.2025.1607246 PMID : 40170693 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11959304/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : What to Look for in Chest X?Rays of Pediatric Patients With COVID?19: Insights From a Colombian Cohort Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, Autor ; Burgos, Claudia, Autor ; Mendez, Laura Melissa, Autor ; Rodriguez, María Margarita, Autor ; Martinez, Arianna, Autor ; Sanchez, Paola, Autor ; Tovar, Carolina, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Triana Rodriguez, Gustavo Adolfo, Autor ; Royero Arias, Mónica, Autor ; Echeverry, Jessica, Autor ; Gamo, Tamara, Autor ; Moreno, Luz Ángela, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Restrepo Gualteros, Sonia, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Piñeros, Juan Gabriel, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez, Iván Felipe, Autor ; Galvis Diaz, Clara, Autor ; Nieto, José Manuel, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Ramirez Varela, Andrea, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Pulmonology Idioma : Inglés (eng) Palabras clave : COVID?19 | diagnostic imaging | EPICO study | intensive care unit | pediatric infection | radiology | SARS?CoV?2 Resumen : Despite advancements in vaccination and the transition from pandemic to endemic, SARS-CoV-2 continues to pose a medical challenge, particularly among children. In this context, imaging diagnostics, such as chest x-rays, are crucial to the initial treatment of patients. This study aims to characterize the radiological findings in pediatric patients with confirmed SARS-CoV-2 infection in Colombia between April 2020 and November 2021, as well as describe the clinical presentation, including those admission to intensive care. Methods: In Colombia, a multicenter cohort comprised patients aged 29 days to 17 years with confirmed SARS-CoV-2 infection and chest X-ray taken within 72 h of hospitalization. In two separate groups, four radiologists evaluated the images. A fifth radiologist reviewed all the X-rays; and subsequently, these readings were used to calculate the kappa coefficient and to solve discrepancies among the other radiologists. The results were compared from admission to intensive care. Results: Analysis was conducted on 392 patients with a median age of 2 years, the majority of whom (42%) were infants. Sixty-eight percent of the radiographs had normal results. Peribronchial thickening and interstitial opacity were the most common aberrant findings (59%), followed by alveolar opacity (12%). 88 percent of findings were bilateral. In our cohort, peribronchial thickening was the most common radiological pattern found in patients admitted the PICU and with ventilatory failure. Interobserver agreement was low for peribronchial thickening (kappa = 0.1), but higher for consolidations and alveolar opacities (kappa = 0.4 and 0.5, respectively). Conclusion: In pediatric patients with SARS-CoV-2, radiological findings are nonspecific and interobserver agreement is minimal. Although consolidation and alveolar opacities demonstrated greater concordance, they did not appear to reflect the clinical presentation; therefore, our results can suggest chest radiography is not considered useful for determining the severity of COVID-19 in Mención de responsabilidad : Claudia Burgos, Laura Melissa Mendez, María Margarita Rodriguez, Arianna Martinez, Paola Sanchez, Carolina Tovar, Melisa Naranjo Vanegas, Gabriela Friedrich, Pablo Vásquez Hoyos, María Lucía Mesa Rubio, Referencia : Pediatr Pulmonol . 2025 Mar;60(3):e27495. doi: 10.1002/ppul.27495. DOI (Digital Object Identifier) : 10.1002/ppul.27495 PMID : 40018994 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40018994/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis What to Look for in Chest X?Rays of Pediatric Patients With COVID?19: Insights From a Colombian Cohort [documento electrónico] / Alejandro Díaz Díaz, Autor ; Burgos, Claudia, Autor ; Mendez, Laura Melissa, Autor ; Rodriguez, María Margarita, Autor ; Martinez, Arianna, Autor ; Sanchez, Paola, Autor ; Tovar, Carolina, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Triana Rodriguez, Gustavo Adolfo, Autor ; Royero Arias, Mónica, Autor ; Echeverry, Jessica, Autor ; Gamo, Tamara, Autor ; Moreno, Luz Ángela, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Restrepo Gualteros, Sonia, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Piñeros, Juan Gabriel, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez, Iván Felipe, Autor ; Galvis Diaz, Clara, Autor ; Nieto, José Manuel, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Ramirez Varela, Andrea, Autor . - 2025.
Obra : Pediatric Pulmonology
Idioma : Inglés (eng)
Palabras clave : COVID?19 | diagnostic imaging | EPICO study | intensive care unit | pediatric infection | radiology | SARS?CoV?2 Resumen : Despite advancements in vaccination and the transition from pandemic to endemic, SARS-CoV-2 continues to pose a medical challenge, particularly among children. In this context, imaging diagnostics, such as chest x-rays, are crucial to the initial treatment of patients. This study aims to characterize the radiological findings in pediatric patients with confirmed SARS-CoV-2 infection in Colombia between April 2020 and November 2021, as well as describe the clinical presentation, including those admission to intensive care. Methods: In Colombia, a multicenter cohort comprised patients aged 29 days to 17 years with confirmed SARS-CoV-2 infection and chest X-ray taken within 72 h of hospitalization. In two separate groups, four radiologists evaluated the images. A fifth radiologist reviewed all the X-rays; and subsequently, these readings were used to calculate the kappa coefficient and to solve discrepancies among the other radiologists. The results were compared from admission to intensive care. Results: Analysis was conducted on 392 patients with a median age of 2 years, the majority of whom (42%) were infants. Sixty-eight percent of the radiographs had normal results. Peribronchial thickening and interstitial opacity were the most common aberrant findings (59%), followed by alveolar opacity (12%). 88 percent of findings were bilateral. In our cohort, peribronchial thickening was the most common radiological pattern found in patients admitted the PICU and with ventilatory failure. Interobserver agreement was low for peribronchial thickening (kappa = 0.1), but higher for consolidations and alveolar opacities (kappa = 0.4 and 0.5, respectively). Conclusion: In pediatric patients with SARS-CoV-2, radiological findings are nonspecific and interobserver agreement is minimal. Although consolidation and alveolar opacities demonstrated greater concordance, they did not appear to reflect the clinical presentation; therefore, our results can suggest chest radiography is not considered useful for determining the severity of COVID-19 in Mención de responsabilidad : Claudia Burgos, Laura Melissa Mendez, María Margarita Rodriguez, Arianna Martinez, Paola Sanchez, Carolina Tovar, Melisa Naranjo Vanegas, Gabriela Friedrich, Pablo Vásquez Hoyos, María Lucía Mesa Rubio, Referencia : Pediatr Pulmonol . 2025 Mar;60(3):e27495. doi: 10.1002/ppul.27495. DOI (Digital Object Identifier) : 10.1002/ppul.27495 PMID : 40018994 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40018994/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America [documento electrónico] / Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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