Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients [documento electrónico] / Carolina Muñoz Grajales,  . - 2016.
Obra : Lupus

Idioma : Inglés (eng)

Palabras clave :	Systemic lupus erythematosus  gender  male  SLEDAI (Systemic Lupus |Erythematosus Disease Activity Index)
Resumen :	Objective: The objective of this paper is to compare disease activity and clinical features at diagnosis in male and female patients with systemic lupus erythematosus (SLE). Methods: This was a cross-sectional study in which every male patient (n 1⁄4 40) was matched with three female patients of the same age (5 years) and racial/ethnic group; disease activity as per the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and disease manifestations at the time of diagnosis were compared. Results: Alopecia and anti-Ro antibodies were more frequent in female patients. No statistically significant difference in any other disease characteristics was found. However, male gender was associated with a risk of severe disease activity at the time of diagnosis (as determined by SLEDAI 12 score) independent of age, racial/ethnic group, anti-Ro positivity or time to criteria accrual (OR: 3.11 95% CI, 1.09–8.92; p 1⁄4 0.035). Conclusion: In newly diagnosed SLE patients, male gender is associated with higher disease activity despite the fact that male and female patients seem to experience similaroverall disease manifestations.
Mención de responsabilidad :	C Muñoz-Grajales, L A González, G S Alarcón, J Acosta-Reyes
Referencia :	Lupus. 2016 Oct;25(11):1217-23.
DOI (Digital Object Identifier) :	10.1177/0961203316635286
PMID :	26921269
En línea :	https://journals.sagepub.com/doi/abs/10.1177/0961203316635286
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3987