The fight against HIV-associated disseminated histoplasmosis in the Americas: unfolding the different stories of four centers / Ángela Restrepo Moreno  

Público ISBD Título : The fight against HIV-associated disseminated histoplasmosis in the Americas: unfolding the different stories of four centers Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, Fecha de publicación : 2019 Títulos uniformes : Journal of Fungi Idioma : Inglés (eng) Palabras clave : HIV  Latin America  awareness  histoplasmosis  leishmaniasis Resumen : Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas in Medellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. Mención de responsabilidad : Mathieu Nacher, Terezinha Silva Leitao, Beatriz L Gómez, Pierre Couppié, Antoine Adenis, Lisandra Damasceno, Magalie Demar, Blanca Samayoa, Diego H Cáceres, Roger Pradinaud, Anastacio de Queiroz Sousa, Eduardo Arathoon, Angela Restrepo Referencia : J Fungi (Basel). 2019 Jun 17;5(2):51. DOI (Digital Object Identifier) : 10.3390/jof5020051 PMID : 31212897 En línea : https://www.mdpi.com/2309-608X/5/2/51 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4246 The fight against HIV-associated disseminated histoplasmosis in the Americas: unfolding the different stories of four centers [documento electrónico] / Ángela Restrepo Moreno,  . - 2019. Obra : Journal of Fungi Idioma : Inglés (eng) Palabras clave : HIV  Latin America  awareness  histoplasmosis  leishmaniasis Resumen : Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas in Medellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. Mención de responsabilidad : Mathieu Nacher, Terezinha Silva Leitao, Beatriz L Gómez, Pierre Couppié, Antoine Adenis, Lisandra Damasceno, Magalie Demar, Blanca Samayoa, Diego H Cáceres, Roger Pradinaud, Anastacio de Queiroz Sousa, Eduardo Arathoon, Angela Restrepo Referencia : J Fungi (Basel). 2019 Jun 17;5(2):51. DOI (Digital Object Identifier) : 10.3390/jof5020051 PMID : 31212897 En línea : https://www.mdpi.com/2309-608X/5/2/51 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4246

Reserva

Reservar este documento

Ejemplares(1)

Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001226	AC-2019-015	Archivo digital	Producción Científica	Artículos científicos	Disponible

---

1 (1 - 1 / 1) Por página: 25 50 100 200