Stage progression and need for renal replacement therapy in a renal protection programme in Colombia. A cohort study = Progreso de estadio y requerimiento de terapia de reemplazo renal en un programa de protección renal en Colombia. Estudio de cohorte [documento electrónico] / Carlos Enrique Yepes Delgado,  . - 2017.
Obra : Nefrología

Idioma : Inglés (eng)

Palabras clave :	Chronic renal failure  renal replacement therapy  end-stage renal failure  evaluation of the effectiveness of interventions  preventive health services
Resumen :	Background: Due to the global burden represented by chronic kidney disease (CKD),the World Health Organization encouraged the implementation of renal protection programmes (RPP) to affect its incidence through prevention and control measures. Objectives: To assess the effectiveness of a Colombian RPP in terms of its effect on the stage progression of CKD and the need for renal replacement therapy (RRT). Methods: An analytical study that monitored 2 cohorts of patients diagnosed with CKD. Thestudy compares the behaviour of clinical and renal impairment indicators from patients exposed to a RPP with that of patients following conventional treatment (CT). The population of both intervention groups was considered when determining the sample size. The incidence rate was calculated as well as patient survival (Kaplan–Meier). In addition, a multivariate analysis (Cox) was used to calculate the influence that exposure to the RPP had on the outcomes of the patients following the RPP and those following CT. Results: The patients exposed to the RPP took longer to advance to the next CKD stage and require RRT. The incidence rate for progression is higher for the patients following CT (0.050, CI 95%: 0.040–0.064) compared to those in the RPP (0.034, CI 95%: 0.030–0.039). The ratio of incidence rates was 1.480 (CI 95%: 1.21–1.90). The hazard of progression was lower for the RPP (HR: 0.855, CI 95%: 0.74–0.98), as was the hazard of requiring RRT (HR: 0.797, CI 95%: 0.606–1.049) Conclusions: The RPP is a secondary prevention strategy against CKD which has an effect on the stage progression of CKD and the need for RRT. Early patient detection has a positive effect on the outcomes studied.
Mención de responsabilidad :	Carlos Enrique Yepes Delgado, Sara Pérez Dávila, Marcela Montoya Jaramillo, Beatriz Elena Orrego Orozco
Referencia :	Nefrologia. 2017 May - Jun;37(3):330-337.
DOI (Digital Object Identifier) :	10.1016/j.nefro.2016.11.023
PMID :	28648207
Derechos de uso :	CC BY-NC-ND
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