Attenuation of the physiological response to infection on adults over 65 years old admitted to the emergency room (ER) [documento electrónico] / Fabián Alberto Jaimes Barragán,  . - 2017.
Obra : Aging Clinical and Experimental Research

Idioma : Inglés (eng)

Palabras clave :	Elderly  sepsis  physiology  infection
Resumen :	It has been considered that the elderly have clinical manifestations different from the ones observed in middle-age adults during an injury event. This hypothesis has not been extensively explored in sepsis and bacterial infections. Secondary analysis of two prospective studies including 2611 patients over 18 years of age admitted to the emergency room with confirmed or probable bacterial infections and sepsis. The outcome measures were heart rate, respiratory rate, systolic blood pressure, temperature, Glasgow Coma Scale, creatinine, PaO2/FiO2 and platelets daily during the first week. Compared to survivors younger than 65, the deceased under 65 had an average heart rate of 12.5 beats per minute per day higher (95% CI 9.32; 15.61), while patients over 65 who died barely had an average 5.7 beats per minute per day higher than the same reference group (95% CI 3.45; 8.06). The systolic blood pressure had a significant decreased in those who died younger than 65, compared to survivors with the same age, in both cohorts (−5.2 mmHg, 95% CI −8.17; −2.23 and −8.5 mmHg, 95% CI −13.48; −3.54, respectively), while those older than 65 who died had a nonsignificant increase (+1.6 mmHg, 95% CI −1.33; 4.62 and +0.1, 95% CI −6.48; 6.72, respectively) compared to the same reference group. The behavior of most clinical and laboratory variables suggests a less pronounced response of subjects above 65 years of age who died 28 days after being diagnosed with sepsis.
Mención de responsabilidad :	Alejandro Marín Valencia, Carlos Eduardo Vallejo, Alba Luz León Alvarez, Fabian Alberto Jaimes
Referencia :	Aging Clin Exp Res. 2017 Oct;29(5):847-856.
DOI (Digital Object Identifier) :	10.1007/s40520-016-0679-2
PMID :	27854067
En línea :	https://link.springer.com/article/10.1007%2Fs40520-016-0679-2
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4087