Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study [documento electrónico] / Sergio Iván Hoyos Duque,  . - 2018.
Obra : Annals of Hepatology

Idioma : Inglés (eng)

Palabras clave :	Liver cancer  prediction  candidate selection.
Resumen :	Background and aims: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America. Material and methods: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Imaging-explanted features were compared in cHCC (non-discordant if pre and post-LT were within Milan, discordant if pre-LT was within and post-LT exceeding Milan). Results: Overall, 435 patients with cHCC and 92 with iHCC were included. At listing, 81% and 91% of cHCC patients were within Milan and San Francisco criteria (UCSF), respectively. Five-year survival and recurrence rates for cHCC within Milan, exceeding Milan/within UCSF and beyond UCSF were 71% and 16%; 66% and 26%; 46% and 55%, respectively. Locoregional treatment prior to LT was performed in 39% of cHCC within Milan, in 53% beyond Milan/within UCSF and in 83% exceeding UCSF (p 1,000 ng/mL 64%; p = 0.12). Discordant imaging-explanted data was observed in 29% of cHCC, showing lower survival HR 2.02 (CI 1.29; 3.15) and higher recurrence rates HR 2.34 when compared to AFP 1,000 ng/mL at listing was independently associated with a higher 5-year recurrence rate and a HR of 3.24 when compared to AFP
Mención de responsabilidad :	Federico Piñero, Paulo Costa, Yuri L Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Martín Fauda, Lucas McCormack, Adrian Gadano, Ilka Sf Boin, Jose H Parente García, Marcelo Silva
Referencia :	Ann Hepatol. 2018 Mar 1;17(2):256-267.
DOI (Digital Object Identifier) :	10.5604/01.3001.0010.8648
PMID :	29469048
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S1665268119301589
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4188