Hemorrhagic cystitis after haploidentical transplantation with post-transplantation cyclophosphamide: protective effect of MESNA continuous infusion / Marcos Arango Barrientos  

Público ISBD Título : Hemorrhagic cystitis after haploidentical transplantation with post-transplantation cyclophosphamide: protective effect of MESNA continuous infusion Tipo de documento : documento electrónico Autores : Marcos Arango Barrientos, Fecha de publicación : 2020 Títulos uniformes : Biology of Blood and Marrow Transplantation Idioma : Inglés (eng) Palabras clave : BK virus  Cyclophosphamide  Cystitis  Haploidentical  MESNA  Transplantation Resumen : Hemorrhagic cystitis (HC) is an important complication after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with post-transplantation cyclophosphamide (PT-CY). Sodium 2-mercaptoethanesulfonate (MESNA) can prevent bladder injury when given with PT-CY. However, the best way to deliver MESNA is not known. This study assessed the incidence of HC after haplo-HSCT with PT-CY with 2 different methods of MESNA administration. The cumulative incidence of HC was lower in patients who received MESNA as a continuous infusion compared with those who received it as an intermittent bolus (5.6% versus 27.8%; P = .01). MESNA administration as an infusion was associated with a lower risk of developing HC (hazard ratio [HR], .19; 95% confidence interval [CI], .04 to .86; P = .02) on univariate analysis. This effect remained significant after adjustment in multivariate analysis (HR, .21; 95% CI, .04 to .88; P = .03). MESNA delivered as a continuous infusion is a simple and potentially useful way to prevent HC after PT-CY. Mención de responsabilidad : Marcos Arango, Doris Cardona Referencia : Biol Blood Marrow Transplant. 2020 Aug;26(8):1492-1496 DOI (Digital Object Identifier) : 10.1016/j.bbmt.2020.04.028 PMID : 32417488 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1083879120302834 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5119 Hemorrhagic cystitis after haploidentical transplantation with post-transplantation cyclophosphamide: protective effect of MESNA continuous infusion [documento electrónico] / Marcos Arango Barrientos,  . - 2020. Obra : Biology of Blood and Marrow Transplantation Idioma : Inglés (eng) Palabras clave : BK virus  Cyclophosphamide  Cystitis  Haploidentical  MESNA  Transplantation Resumen : Hemorrhagic cystitis (HC) is an important complication after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with post-transplantation cyclophosphamide (PT-CY). Sodium 2-mercaptoethanesulfonate (MESNA) can prevent bladder injury when given with PT-CY. However, the best way to deliver MESNA is not known. This study assessed the incidence of HC after haplo-HSCT with PT-CY with 2 different methods of MESNA administration. The cumulative incidence of HC was lower in patients who received MESNA as a continuous infusion compared with those who received it as an intermittent bolus (5.6% versus 27.8%; P = .01). MESNA administration as an infusion was associated with a lower risk of developing HC (hazard ratio [HR], .19; 95% confidence interval [CI], .04 to .86; P = .02) on univariate analysis. This effect remained significant after adjustment in multivariate analysis (HR, .21; 95% CI, .04 to .88; P = .03). MESNA delivered as a continuous infusion is a simple and potentially useful way to prevent HC after PT-CY. Mención de responsabilidad : Marcos Arango, Doris Cardona Referencia : Biol Blood Marrow Transplant. 2020 Aug;26(8):1492-1496 DOI (Digital Object Identifier) : 10.1016/j.bbmt.2020.04.028 PMID : 32417488 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1083879120302834 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5119

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