Colombian experience in the treatment of hepatitis C with direct-acting antiviral agents = Experiencia colombiana en el tratamiento de la hepatitis C con agentes antivirales de acción directa [documento electrónico] / Juan Ignacio Marín Zuluaga, ; Óscar Mauricio Santos Sánchez,  . - 2019.
Obra : Medicina (Buenos Aires)

Idioma : Inglés (eng)

Palabras clave :	Antiviral agents  drug therapy  hepatitis C  chronic hepatitis  liver transplantation  treatment outcome
Resumen :	There are few published real-world studies on hepatitis C in Latin America. This paper describes a cohort of Colombian subjects treated with direct-acting antiviral agents. A total of 195 patients from 5 hepatology centers in 4 Colombian cities were retrospectively studied. For each patient, serum biomarkers were obtained, and Child-Pugh, MELD, cirrhosis and fibrosis stage were calculated. Additionally, viral load was quantified at initiation, end of treatment and at 12 weeks of completion. Adverse effects were recorded. Patients with liver transplant were compared with non-transplanted patients in terms of serum biomarkers. The patients had received 9 different regimes. The most prevalent viral genotype was 1b (81.5%). Overall, 186 patients (95.4%) attained sustained virologic response. When comparing transplanted vs. non-transplanted patients, those in the non-transplanted group were more likely to have cirrhosis (52.6% vs. 12.5%, p = 0.0004). Pre-treatment viral load was higher in the transplant group (1 743 575 IQR = 1 038 062-4 252 719 vs. 345 769 IQR = 125 806-842 239; p
Mención de responsabilidad :	Adriana Varón, Luisa Santos, Mónica Tapias, Clara Cáez, Juan Ignacio Marín, Oscar Santos, Martín Garzón, Oscar Beltrán, Andrés Gómez-Aldana, Ismael J Yepes, Martín Rondón, Diego Rosselli
Referencia :	Medicina (B Aires). 2019;79(1):29-36
PMID :	30694186
Derechos de uso :	CC BY-NC
En línea :	http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-768020190001000 [...]
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