| Título : |
Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage |
| Tipo de documento : |
documento electrónico |
| Autores : |
Velez, Alejandro, Autor ; Huang, Xiaosong, Autor ; Lott, Paul C, Autor ; Hu, Donglei, Autor ; Zavala, Valentina A, Autor ; Jamal, Zoeb N, Autor ; Vidaurre, Tatiana, Autor ; Casavilca Zambrano, Sandro, Autor ; Navarro Vásquez, Jeannie, Autor ; Castañeda, Carlos A, Autor ; Valencia, Guillermo, Autor ; Morante, Zaida, Autor ; Calderón, Mónica, Autor ; Abugattas, Julio E, Autor ; Fuentes, Hugo A, Autor ; Liendo Picoaga, Ruddy, Autor ; Cotrina, Jose M, Autor ; Neciosup, Silvia P, Autor ; Rioja Viera, Patricia, Autor ; Salinas, Luis A, Autor ; Gálvez Nino, Marco, Autor ; Huntsman, Scott, Autor ; Sanchez, Sixto E, Autor ; Williams, Michelle A, Autor ; Gelaye, Bizu, Autor ; Estrada Florez, Ana P, Autor ; Polanco Echeverry, Guadalupe, Autor ; Echeverry, Magdalena, Autor ; Carmona Valencia, Jenny A, Autor ; Bohórquez Lozano, Mabel E, Autor ; Torres, Javier, Autor ; Cruz, Miguel A., Autor ; Ho, Weang Kee, Autor ; Teo, Soo Hwang, Autor ; Tai, Mei Chee, Autor ; John, Esther M, Autor ; Haiman, Christopher A, Autor ; Conti, David V, Autor ; Chen, Fei, Autor ; Torres Mejía, Gabriela, Autor ; Kushi, Lawrence H, Autor ; Neuhausen, Susan L, Autor ; Ziv, Elad, Autor ; Carvajal Carmona, Luis G, Autor ; Fejerman, Laura, Autor |
| Fecha de publicación : |
2025 |
| Títulos uniformes : |
Cancer Epidemiology Biomarkers and Prevention
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
MeSH Adult; Breast Neoplasms; Female; Genetic Predisposition to Disease; Genetic Risk Score; Hispanic or Latino; Humans; Latin America; Middle Aged; Multifactorial Inheritance; Polymorphism Single Nucleotide; Risk Assessment; Risk Factors; White EMTREE medical terms adult; aged; ancestry group; Article; Asian; breast cancer; cancer risk; case control study; Colombia; controlled study; female; genetic predisposition; genetic risk score; human; major clinical study; Peruvian; prediction; single nucleotide polymorphism; breast tumor; Caucasian; ethnology; genetic predisposition; genetic risk score; genetics; Hispanic; middle aged; multifactorial inheritance; procedures; risk assessment; risk factor; South and Central America |
| Resumen : |
Background: A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of European (EUR) and Asian ancestries, have been combined to construct a polygenic risk score (PRS) to predict breast cancer risk, but the prediction accuracy of existing PRSs in Hispanic/Latinx individuals (H/L) remain relatively low. We assessed the performance of several existing PRS panels with and without addition of H/L-specific variants among self-reported H/L women. Methods: PRS performance was evaluated using multivariable logistic regression and the area under the ROC curve. Results: Both EUR and Asian PRSs performed worse in H/L samples compared with original reports. The best EUR PRS performed better than the best Asian PRS in pooled H/L samples. EUR PRSs had decreased performance with increasing Indigenous American (IA) ancestry, while Asian PRSs had increased performance with increasing IA ancestry. The addition of two H/L SNPs increased performance for all PRSs, most notably in the samples with high IA ancestry, and did not impact the performance of PRSs in individuals with lower IA ancestry. Conclusions: A single PRS that incorporates risk variants relevant to the multiple ancestral components of individuals from Latin America, instead of a set of ancestry-specific panels, could be used in clinical practice. |
| Mención de responsabilidad : |
Huang, Xiaosong; Lott, Paul C, Hu, Donglei; Zavala, Valentina A.; Jamal, Zoeb N.; Vidaurre, Tatiana; Casavilca-Zambrano, Sandro; Vásquez, Jeannie Navarro; Castañeda, Carlos A.; Valencia, Guillermo; Morante, Zaida; Calderón, Mónica; Abugattas, Julio E.; Fuentes, Hugo A.; Liendo-Picoaga, Ruddy; Cotrina, Jose M.; Neciosup, Silvia P.; Viera, Patricia Rioja; Salinas, Luis A.; Galvez-Nino, Marco; Huntsman, Scott; Sanchez, Sixto E.; Williams, Michelle A.; Gelaye, Bizu; Estrada-Florez, Ana P.; Polanco-Echeverry, Guadalupe; Echeverry, Magdalena; Velez, Alejandro; Carmona-Valencia, Jenny A.; Bohorquez-Lozano, Mabel E.; Torres, Javier; Cruz, Miguel; Ho, Weang-Kee; Teo, Soo Hwang; Tai, Mei Chee; John, Esther M.; Haiman, Christopher A.; Conti, David V.; Chen, Fei; Torres-Mejía, Gabriela; Kushi, Lawrence H.; Neuhausen, Susan L.; Ziv, Elad; Carvajal-Carmona, Luis G. |
| Referencia : |
Cancer Epidemiol Biomarkers Prev . 2025 Feb 6;34(2):234-245 |
| DOI (Digital Object Identifier) : |
10.1158/1055-9965.EPI-24-1247. |
| PMID : |
39625644 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://pubmed.ncbi.nlm.nih.gov/39625644/ |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage [documento electrónico] / Velez, Alejandro, Autor ; Huang, Xiaosong, Autor ; Lott, Paul C, Autor ; Hu, Donglei, Autor ; Zavala, Valentina A, Autor ; Jamal, Zoeb N, Autor ; Vidaurre, Tatiana, Autor ; Casavilca Zambrano, Sandro, Autor ; Navarro Vásquez, Jeannie, Autor ; Castañeda, Carlos A, Autor ; Valencia, Guillermo, Autor ; Morante, Zaida, Autor ; Calderón, Mónica, Autor ; Abugattas, Julio E, Autor ; Fuentes, Hugo A, Autor ; Liendo Picoaga, Ruddy, Autor ; Cotrina, Jose M, Autor ; Neciosup, Silvia P, Autor ; Rioja Viera, Patricia, Autor ; Salinas, Luis A, Autor ; Gálvez Nino, Marco, Autor ; Huntsman, Scott, Autor ; Sanchez, Sixto E, Autor ; Williams, Michelle A, Autor ; Gelaye, Bizu, Autor ; Estrada Florez, Ana P, Autor ; Polanco Echeverry, Guadalupe, Autor ; Echeverry, Magdalena, Autor ; Carmona Valencia, Jenny A, Autor ; Bohórquez Lozano, Mabel E, Autor ; Torres, Javier, Autor ; Cruz, Miguel A., Autor ; Ho, Weang Kee, Autor ; Teo, Soo Hwang, Autor ; Tai, Mei Chee, Autor ; John, Esther M, Autor ; Haiman, Christopher A, Autor ; Conti, David V, Autor ; Chen, Fei, Autor ; Torres Mejía, Gabriela, Autor ; Kushi, Lawrence H, Autor ; Neuhausen, Susan L, Autor ; Ziv, Elad, Autor ; Carvajal Carmona, Luis G, Autor ; Fejerman, Laura, Autor . - 2025. Obra : Cancer Epidemiology Biomarkers and PreventionIdioma : Inglés ( eng)
| Palabras clave : |
MeSH Adult; Breast Neoplasms; Female; Genetic Predisposition to Disease; Genetic Risk Score; Hispanic or Latino; Humans; Latin America; Middle Aged; Multifactorial Inheritance; Polymorphism Single Nucleotide; Risk Assessment; Risk Factors; White EMTREE medical terms adult; aged; ancestry group; Article; Asian; breast cancer; cancer risk; case control study; Colombia; controlled study; female; genetic predisposition; genetic risk score; human; major clinical study; Peruvian; prediction; single nucleotide polymorphism; breast tumor; Caucasian; ethnology; genetic predisposition; genetic risk score; genetics; Hispanic; middle aged; multifactorial inheritance; procedures; risk assessment; risk factor; South and Central America |
| Resumen : |
Background: A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of European (EUR) and Asian ancestries, have been combined to construct a polygenic risk score (PRS) to predict breast cancer risk, but the prediction accuracy of existing PRSs in Hispanic/Latinx individuals (H/L) remain relatively low. We assessed the performance of several existing PRS panels with and without addition of H/L-specific variants among self-reported H/L women. Methods: PRS performance was evaluated using multivariable logistic regression and the area under the ROC curve. Results: Both EUR and Asian PRSs performed worse in H/L samples compared with original reports. The best EUR PRS performed better than the best Asian PRS in pooled H/L samples. EUR PRSs had decreased performance with increasing Indigenous American (IA) ancestry, while Asian PRSs had increased performance with increasing IA ancestry. The addition of two H/L SNPs increased performance for all PRSs, most notably in the samples with high IA ancestry, and did not impact the performance of PRSs in individuals with lower IA ancestry. Conclusions: A single PRS that incorporates risk variants relevant to the multiple ancestral components of individuals from Latin America, instead of a set of ancestry-specific panels, could be used in clinical practice. |
| Mención de responsabilidad : |
Huang, Xiaosong; Lott, Paul C, Hu, Donglei; Zavala, Valentina A.; Jamal, Zoeb N.; Vidaurre, Tatiana; Casavilca-Zambrano, Sandro; Vásquez, Jeannie Navarro; Castañeda, Carlos A.; Valencia, Guillermo; Morante, Zaida; Calderón, Mónica; Abugattas, Julio E.; Fuentes, Hugo A.; Liendo-Picoaga, Ruddy; Cotrina, Jose M.; Neciosup, Silvia P.; Viera, Patricia Rioja; Salinas, Luis A.; Galvez-Nino, Marco; Huntsman, Scott; Sanchez, Sixto E.; Williams, Michelle A.; Gelaye, Bizu; Estrada-Florez, Ana P.; Polanco-Echeverry, Guadalupe; Echeverry, Magdalena; Velez, Alejandro; Carmona-Valencia, Jenny A.; Bohorquez-Lozano, Mabel E.; Torres, Javier; Cruz, Miguel; Ho, Weang-Kee; Teo, Soo Hwang; Tai, Mei Chee; John, Esther M.; Haiman, Christopher A.; Conti, David V.; Chen, Fei; Torres-Mejía, Gabriela; Kushi, Lawrence H.; Neuhausen, Susan L.; Ziv, Elad; Carvajal-Carmona, Luis G. |
| Referencia : |
Cancer Epidemiol Biomarkers Prev . 2025 Feb 6;34(2):234-245 |
| DOI (Digital Object Identifier) : |
10.1158/1055-9965.EPI-24-1247. |
| PMID : |
39625644 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://pubmed.ncbi.nlm.nih.gov/39625644/ |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Clasificado(s) por (Año de edición descendente) Refinar búsquedaEvaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage / Velez, Alejandro ; Huang, Xiaosong ; Lott, Paul C ; Hu, Donglei ; Zavala, Valentina A ; Jamal, Zoeb N ; Vidaurre, Tatiana ; Casavilca Zambrano, Sandro ; Navarro Vásquez, Jeannie ; Castañeda, Carlos A ; Valencia, Guillermo ; Morante, Zaida ; Calderón, Mónica ; Abugattas, Julio E ; Fuentes, Hugo A ; Liendo Picoaga, Ruddy ; Cotrina, Jose M ; Neciosup, Silvia P ; Rioja Viera, Patricia ; Salinas, Luis A ; Gálvez Nino, Marco ; Huntsman, Scott ; Sanchez, Sixto E ; Williams, Michelle A ; Gelaye, Bizu ; Estrada Florez, Ana P ; Polanco Echeverry, Guadalupe ; Echeverry, Magdalena ; Carmona Valencia, Jenny A ; Bohórquez Lozano, Mabel E ; Torres, Javier ; Cruz, Miguel A. ; Ho, Weang Kee ; Teo, Soo Hwang ; Tai, Mei Chee ; John, Esther M ; Haiman, Christopher A ; Conti, David V ; Chen, Fei ; Torres Mejía, Gabriela ; Kushi, Lawrence H ; Neuhausen, Susan L ; Ziv, Elad ; Carvajal Carmona, Luis G ; Fejerman, Laura
