In vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents [documento electrónico] / Ángela Restrepo Moreno, ; Catalina de Bedout Gómez, ; Ángela María Tabares Velásquez,  . - 1984.
Obra : Revista do Instituto de Medicina Tropical de São Paulo

Idioma : Inglés (eng)

Resumen :	A study was conducted to determine the susceptibility of P. brasiliensis yeast form to amphotericin B (A), ketoconazole (K), 5-fluorocytosine (5-FC) and rifampin (R). The three isolates tested produced minimal inhibitory concentrations (MICs) (mcg/ml) in the following range: A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 and R: 40-80. The minimal fungicidal concentrations (MFC) were several times higher than the corresponding MICs. Precise MFC for 5-FC were not obtained (> 500 mcg/ml). Combination of K plus A proved synergic, with the fractional inhibitory concentration (FIC) indices revealing synergy when the drugs were combined at the 1 to 1 and 1 to 5 MIC ratios. R (40 mcg/ml) appeared to antagonize K. These results indicate promise for the combined use of K plus A as a therapeutical regimen.
Mención de responsabilidad :	RESTREPO, Angela and TABARES, Catalina de Bedout and Angela M.
Referencia :	Rev Inst Med Trop Sao Paulo. Nov-Dec 1984;26(6):322-8.
DOI (Digital Object Identifier) :	10.1590/S0036-46651984000600006
PMID :	6100138
Derechos de uso :	CC BY-NC
En línea :	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651984000600006
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