Adrenal function in paracoccidioidomycosis: A prospective study in patients before and after ketoconazole therapy [documento electrónico] / Iván Gómez, ; Ángela Restrepo Moreno,  . - 1986.
Obra : Infection

Idioma : Inglés (eng)

Resumen :	The adrenal gland functional reserve was studied in a group of 22 patients with active paracoccidioidomycosis before therapy and in 18 of the same patients after termination of six months of ketoconazole treatment. 22 control subjects were also tested. Serum cortisol was measured before and after i.v. infusion of 250 µg of corticotropin given over a period of two hours. Basal cortisol levels were subnormal in only one patient before treatment and in four of 18 patients after therapy. Overt Addison's disease was found in 14% of the patients before treatment. However, corticotropin stimulation revealed diminished adrenal reserve in 23% of patients before, and in 44% of the patients after treatment. Although decreased adrenal cortex function after therapy may be influenced by ketoconazole, more studies are needed to determine the role of this agent after prolonged use. The high frequency of subclinical adrenal failure in paracoccidioidomycosis should alert clinicians in charge of such patients, should they face physiological stress.
Mención de responsabilidad :	A. Abad M.D., P. Velez M. T., I. Gomez M.D. & Angela Restrepo Ph. D.
Referencia :	Infection. Jan-Feb 1986;14(1):22-6.
DOI (Digital Object Identifier) :	10.1007/BF01644805
PMID :	3007365
En línea :	https://link.springer.com/article/10.1007%2FBF01644805
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4341