Predictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis [documento electrónico] / Luz Elena Cano Restrepo, Autor ; Ángela Restrepo Moreno, Autor . - 1987.
Obra : Revista do Instituto de Medicina Tropical de São Paulo

Idioma : Inglés (eng)

Palabras clave :	Predictive values  Serologic tests  Paracoccidoidomycosis  Cross-reactions  Systemic mycoses
Resumen :	A serologic study was undertaken in a group of 43 patients with active paracoccidioidomycosis who were treated in the same form (ketoconazole), for identical periods of time (6 months), and folio wed-up for various periods posttherapy. The tests employed were agar gel immunodiffusion (AGID) and complement fixation (FC). Also studied were 50 sera from patients with proven histoplasmosis and pulmonary aspergilloma, 30 patients with culturaly proven tuberculosis as well as 92 specimens from healthy individuals, residents in the endemic area for paracoccidioidomycosis. A single lot of yeast filtrate antigen was used throughout the study. The value of each test was measured according to GALEN and GAMBINO6. Both tests were highly sensitive, 89 and 93% respectively. Regarding their specificity, the AGID was totally specific while the CF exhibited 96.6% and 97% specificity in front of tuberculosis patients and healthy individuals respectively and 82% in comparison with patients with other mycoses. The concept of predictive value, that is, the certainty one has in accepting a positive test as diagnostic of paracoccidioidomycosis, favored the AGID procedure (100%) over the CF test. The latter could sort out with 93% certainty a patient with paracoccidioidomycosis among a group of healthy individuals and with 97.5% in the case of TB patients; when the group in question was composed by individuals with other deep mycoses, such certainty was lower (81%). The above results indicate that both the AGID and the CF tests furnish results of high confidence; one should not relay, however, in the CF alone as a means to establish the specific diagnosis of paracoccidioidomycosis.
Mención de responsabilidad :	CANO, Luz Elena and RESTREPO, Angela
Referencia :	Rev Inst Med Trop Sao Paulo. Sep-Oct 1987;29(5):276-83.
DOI (Digital Object Identifier) :	10.1590/S0036-46651987000500003
PMID :	3136529
Derechos de uso :	CC BY-NC
En línea :	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651987000500003
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