Single daily dose amikacin in paediatric patients with severe gram-negative infections [documento electrónico] / David Andrés Espinal Botero, ; Hugo Trujillo Soto,  . - 1991.
Obra : Journal of Antimicrobial Chemotherapy

Idioma : Inglés (eng)

Resumen :	Twenty-five children with serious Gram-negative infections were treated in a prospective study with amikacin 20 mg/kg administered in a single daily dose as a 30 min iv infusion for 4 to 12 days. In nine cases the amikacin was combined with β-lactam antibiotics. Escherichia coli were the most frequent bacteria isolated followed by K. pneumoniae, Providencia and Enterobacter spp. and Pseudomonas aeruginosa with MICs ranging from 1 to 16 mg/l. Mean (±S.D.) peak and trough concentrations of days 1 and 4 of therapy ranged from 49+13·5 to 53·6±13·4 mg/l and 6±1·4 to 7·7+4·1 mg/l respectively. All patients were clinically and bacteriologically cured. No significant adverse reactions were observed. The results suggest that administration of a single daily dose of 20 mg/kg amikacin should be considered practical and safe in children. Further studies are needed.
Mención de responsabilidad :	Hugo Trujillo, Jaime Robledo, Carlos Robledo, David Espinal, Gloria Garces, Jorje Mejia, Carlos Restrepo, Felipe Restrepo, Gloria Isabel Mejia de Rodriguez, Marta Claudia Tamayo de Guitierrez
Referencia :	J Antimicrob Chemother. 1991 May;27 Suppl C:141-7
DOI (Digital Object Identifier) :	10.1093/jac/27.suppl_c.141
PMID :	1856143
En línea :	https://academic.oup.com/jac/article-abstract/27/suppl_C/141/660223
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4359