| Título : |
Moderate alcohol-associated hepatitis: A real-world multicenter study |
| Tipo de documento : |
documento electrónico |
| Autores : |
Juan Carlos Restrepo Gutiérrez, Autor ; Díaz, Luis Antonio, Autor ; Dunn, Winston, Autor ; Mehta, Heer, Autor ; Muñoz, Karen, Autor ; Caldentey, Vicente, Autor ; Arnold, Jorge, Autor ; Ayares, Gustavo, Autor ; Mortuza, Rokhsana, Autor ; Sarin, Shiv K., Autor ; Maiwall, Rakhi, Autor ; Zhang, Wei, Autor ; Qian, Steve, Autor ; Simonetto, Douglas, Autor ; Singal, Ashwani K., Autor ; Elfeki, Mohamed A., Autor ; Ramirez Cadiz, Carolina, Autor ; Malhi, Gurpreet, Autor ; Ahmed, Adan, Autor ; Homsi, Hoomam, Autor ; Abid, Zinia, Autor ; Cabezas, Joaquín, Autor ; Echavarría, Victor, Autor ; Poca, Maria, Autor ; Soriano, German, Autor ; Cuyas, Berta, Autor ; Ventura Cots, Meritxell, Autor ; Higuera De La Tijera, María Fátima, Autor ; Ayala Valverde, Maria, Autor ; Pérez, Diego, Autor ; Gomez, Jaime, Autor ; Al-Karaghouli, Mustafa, Autor ; Jalal, Prasun K., Autor ; Ibrahim, Mohamad Ali, Autor ; García Tsao, Guadalupe, Autor ; Goyes, Daniela, Autor ; Skladaný, Lubomir, Autor ; Havaj, Daniel J., Autor ; Adamcova Selcanova, Svetlana, Autor ; Rincón, Diego, Autor ; Chacko, Kristina R., Autor ; Yaquich, Pamela, Autor ; Toro, Luis G., Autor ; Shah, Vijay, Autor ; Arrese, Marco, Autor ; Kamath, Patrick S., Autor ; Bataller, Ramon, Autor ; Arab, Juan Pablo, Autor |
| Fecha de publicación : |
2025 |
| Títulos uniformes : |
Hepatology Communications
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a "less severe condition" (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009-2019) included patients with mAH (MELD score ?20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ?20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15-19), Maddrey discriminant function (mDF) of 33 (22-40), the trajectory of serum bilirubin of 0.83 (0.60-1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96-8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27-1.76, p |
| Mención de responsabilidad : |
Idalsoaga, Francisco1,2; Díaz, Luis Antonio1,3; Dunn, Winston4; Mehta, Heer4; Muñoz, Karen5; Caldentey, Vicente5; Arnold, Jorge1; Ayares, Gustavo2; Mortuza, Rokhsana2; Sarin, Shiv K.6; Maiwall, Rakhi6; Zhang, Wei7; Qian, Steve8; Simonetto, Douglas9; Singal, Ashwani K.10; Elfeki, Mohamed A.10; Ramirez-Cadiz, Carolina11; Malhi, Gurpreet2; Ahmed, Adan2; Homsi, Hoomam2; Abid, Zinia2; Cabezas, Joaquín12,13; Echavarría, Victor12,13; Poca, Maria14; Soriano, German14; Cuyas, Berta14; Ventura Cots, Meritxell15; Higuera-De La Tijera, María Fátima16; Ayala-Valverde, Maria17; Perez, Diego17; Gomez, Jaime17; Abraldes, Juan G18; Al-Karaghouli, Mustafa18; Jalal, Prasun K.19; Ibrahim, Mohamad Ali19; García-Tsao, Guadalupe20; Goyes, Daniela20; Skladaný, Lubomir21; Havaj, Daniel J.21; Sulejova, Karolina21; Adamcova Selcanova, Svetlana21; Rincón, Diego22,23; Chacko, Kristina R.24; Restrepo, Juan C.25; Yaquich, Pamela26; Toro, Luis G.27; Shah, Vijay9; Arrese, Marco1; Kamath, Patrick S.9; Bataller, Ramon28 |
| Referencia : |
Hepatology Communications 9(4):e0673, April 2025. |
| DOI (Digital Object Identifier) : |
10.1097/HC9.0000000000000673 |
| Derechos de uso : |
CC BY |
| En línea : |
https://journals.lww.com/hepcomm/fulltext/2025/04010/moderate_alcohol_associated [...] |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Moderate alcohol-associated hepatitis: A real-world multicenter study [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor ; Díaz, Luis Antonio, Autor ; Dunn, Winston, Autor ; Mehta, Heer, Autor ; Muñoz, Karen, Autor ; Caldentey, Vicente, Autor ; Arnold, Jorge, Autor ; Ayares, Gustavo, Autor ; Mortuza, Rokhsana, Autor ; Sarin, Shiv K., Autor ; Maiwall, Rakhi, Autor ; Zhang, Wei, Autor ; Qian, Steve, Autor ; Simonetto, Douglas, Autor ; Singal, Ashwani K., Autor ; Elfeki, Mohamed A., Autor ; Ramirez Cadiz, Carolina, Autor ; Malhi, Gurpreet, Autor ; Ahmed, Adan, Autor ; Homsi, Hoomam, Autor ; Abid, Zinia, Autor ; Cabezas, Joaquín, Autor ; Echavarría, Victor, Autor ; Poca, Maria, Autor ; Soriano, German, Autor ; Cuyas, Berta, Autor ; Ventura Cots, Meritxell, Autor ; Higuera De La Tijera, María Fátima, Autor ; Ayala Valverde, Maria, Autor ; Pérez, Diego, Autor ; Gomez, Jaime, Autor ; Al-Karaghouli, Mustafa, Autor ; Jalal, Prasun K., Autor ; Ibrahim, Mohamad Ali, Autor ; García Tsao, Guadalupe, Autor ; Goyes, Daniela, Autor ; Skladaný, Lubomir, Autor ; Havaj, Daniel J., Autor ; Adamcova Selcanova, Svetlana, Autor ; Rincón, Diego, Autor ; Chacko, Kristina R., Autor ; Yaquich, Pamela, Autor ; Toro, Luis G., Autor ; Shah, Vijay, Autor ; Arrese, Marco, Autor ; Kamath, Patrick S., Autor ; Bataller, Ramon, Autor ; Arab, Juan Pablo, Autor . - 2025. Obra : Hepatology CommunicationsIdioma : Inglés ( eng)
| Resumen : |
Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a "less severe condition" (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009-2019) included patients with mAH (MELD score ?20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ?20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15-19), Maddrey discriminant function (mDF) of 33 (22-40), the trajectory of serum bilirubin of 0.83 (0.60-1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96-8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27-1.76, p |
| Mención de responsabilidad : |
Idalsoaga, Francisco1,2; Díaz, Luis Antonio1,3; Dunn, Winston4; Mehta, Heer4; Muñoz, Karen5; Caldentey, Vicente5; Arnold, Jorge1; Ayares, Gustavo2; Mortuza, Rokhsana2; Sarin, Shiv K.6; Maiwall, Rakhi6; Zhang, Wei7; Qian, Steve8; Simonetto, Douglas9; Singal, Ashwani K.10; Elfeki, Mohamed A.10; Ramirez-Cadiz, Carolina11; Malhi, Gurpreet2; Ahmed, Adan2; Homsi, Hoomam2; Abid, Zinia2; Cabezas, Joaquín12,13; Echavarría, Victor12,13; Poca, Maria14; Soriano, German14; Cuyas, Berta14; Ventura Cots, Meritxell15; Higuera-De La Tijera, María Fátima16; Ayala-Valverde, Maria17; Perez, Diego17; Gomez, Jaime17; Abraldes, Juan G18; Al-Karaghouli, Mustafa18; Jalal, Prasun K.19; Ibrahim, Mohamad Ali19; García-Tsao, Guadalupe20; Goyes, Daniela20; Skladaný, Lubomir21; Havaj, Daniel J.21; Sulejova, Karolina21; Adamcova Selcanova, Svetlana21; Rincón, Diego22,23; Chacko, Kristina R.24; Restrepo, Juan C.25; Yaquich, Pamela26; Toro, Luis G.27; Shah, Vijay9; Arrese, Marco1; Kamath, Patrick S.9; Bataller, Ramon28 |
| Referencia : |
Hepatology Communications 9(4):e0673, April 2025. |
| DOI (Digital Object Identifier) : |
10.1097/HC9.0000000000000673 |
| Derechos de uso : |
CC BY |
| En línea : |
https://journals.lww.com/hepcomm/fulltext/2025/04010/moderate_alcohol_associated [...] |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Clasificado(s) por (Año de edición descendente) Refinar búsquedaModerate alcohol-associated hepatitis: A real-world multicenter study / Juan Carlos Restrepo Gutiérrez ; Díaz, Luis Antonio ; Dunn, Winston ; Mehta, Heer ; Muñoz, Karen ; Caldentey, Vicente ; Arnold, Jorge ; Ayares, Gustavo ; Mortuza, Rokhsana ; Sarin, Shiv K. ; Maiwall, Rakhi ; Zhang, Wei ; Qian, Steve ; Simonetto, Douglas ; Singal, Ashwani K. ; Elfeki, Mohamed A. ; Ramirez Cadiz, Carolina ; Malhi, Gurpreet ; Ahmed, Adan ; Homsi, Hoomam ; Abid, Zinia ; Cabezas, Joaquín ; Echavarría, Victor ; Poca, Maria ; Soriano, German ; Cuyas, Berta ; Ventura Cots, Meritxell ; Higuera De La Tijera, María Fátima ; Ayala Valverde, Maria ; Pérez, Diego ; Gomez, Jaime ; Al-Karaghouli, Mustafa ; Jalal, Prasun K. ; Ibrahim, Mohamad Ali ; García Tsao, Guadalupe ; Goyes, Daniela ; Skladaný, Lubomir ; Havaj, Daniel J. ; Adamcova Selcanova, Svetlana ; Rincón, Diego ; Chacko, Kristina R. ; Yaquich, Pamela ; Toro, Luis G. ; Shah, Vijay ; Arrese, Marco ; Kamath, Patrick S. ; Bataller, Ramon ; Arab, Juan Pablo
