Activity of two different triazoles in a murine model of paracoccidioidomycosis [documento electrónico] / Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno,  . - 1992.
Obra : Revista do Instituto de Medicina Tropical de São Paulo

Idioma : Inglés (eng)

Palabras clave :	Paracoccidioidomycosis  Experimental  Treatment  Triazole  Itraconazol  Schering 39304
Resumen :	A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis.
Mención de responsabilidad :	Susana Restrepo; Angela M. Tabares; Angela Restrepo
Referencia :	Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6.
DOI (Digital Object Identifier) :	10.1590/s0036-46651992000200014
PMID :	1340032
Derechos de uso :	CC BY-NC
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