Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin [documento electrónico] / Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno,  . - 1994.
Obra : Infection and Immunity

Idioma : Inglés (eng)

Resumen :	Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells.
Mención de responsabilidad :	L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens
Referencia :	Infect Immun. 1994 Apr;62(4):1494-5.
PMID :	8132359
En línea :	https://iai.asm.org/content/62/4/1494
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375