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Autor Aguillon, David Fernando
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Documentos disponibles escritos por este autor (3)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaAssociation between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia / Sergio Álvarez Vallejo ; Martín Ochoa Escudero ; Kaplan, Elizabeth ; Zuluaga, Yesica ; Vasquez, Daniel ; Hincapie, Liliana ; Aguillon, David Fernando ; Madrigal, Lucia ; Baena, Ana Y ; Vila Castelar, Clara ; Giraldo Chica, Margarita M ; Ramirez Gomez, Liliana A ; Langella, Stephanie ; Arboleda Velasquez, Joseph F ; Lopera, Francisco ; Quiroz, Yakeel T
Título : Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimers Dement Idioma : Inglés (eng) Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia [documento electrónico] / Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor . - 2025.
Obra : Alzheimers Dement
Idioma : Inglés (eng)
Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Associations among mild behavioral impairment symptoms, brain pathology and cognition in individuals with autosomal?dominant Alzheimer’s disease: Findings from the Colombia?Boston (COLBOS) biomarker study Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Vasquez, Daniel, Autor ; Aguillon, David Fernando, Autor ; Baena, Ana Y, Autor ; Langella, Stephanie, Autor ; Munera, Diana, Autor ; Zubiri, Victoria, Autor ; Ramos, Claudia, Autor ; Kaplan, Elizabeth, Autor ; Pluim McDowell, Celina F, Autor ; Martinez, Jairo E, Autor ; Giudicessi, Averi, Autor ; Badillo Cabrera, Alex L, Autor ; Bonillas Félix, Nikole A, Autor ; Vila Castelar, Clara, Autor ; Ramirez Gomez, Liliana A, Autor ; Lopera, Francisco, Autor ; Gatchel, Jennifer R, Autor ; Quiroz, Yakeel T, Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimers Dement Idioma : Inglés (eng) Resumen : Background Neuropsychiatric symptoms (NPS) are common in early stages of Alzheimer’s disease (AD) and may be early markers of cognitive decline and dementia in older individuals. The Mild Behavioral Impairment Checklist (MBI?C) was developed to capture new?onset transdiagnostic NPS in individuals at risk of dementia. We sought to determine whether mild behavioral impairment symptoms are elevated in non?demented Presenilin?1 (PSEN1) E280A carriers, who are genetically determined to develop dementia by their 50s. We hypothesized that those with higher MBI?C total scores would have worse memory performance and greater brain pathology. Method A total of 25 mutation carriers (mean age = 36.3±7.23; 56% females; 18 cognitively?unimpaired, 7 impaired) and 30 non?carriers (70% females) from the Colombia?Boston (COLBOS) Biomarker study were included. All participants completed cognitive testing, the MBI?C (self?reported), and florbetapir (amyloid), flortaucipir (tau) PET, and structural magnetic resonance imaging. We used Mann?Whitney Test to examine group differences, and Spearman’s correlation and linear regression to examine associations among MBI?C total score, Geriatric Depression Scale?15 (GDS), Mini?Mental State Examination (MMSE), CERAD word list learning delayed recall, cortical amyloid burden, regional tau, and hippocampal volume. In sensitivity analyses, we restricted carriers to the 18 unimpaired. Resul MBI?C total scores were similar between carriers and non?carriers (p = 0.09). Compared to non?carriers, carriers had greater amyloid burden (r = 0.55; p = 0.004) and lower hippocampal volume (r = ?0.43; p = 0.034). Among all carriers, higher MBI?C total scores were associated with lower hippocampal volume (r = ?0.44; p = 0.034), greater amyloid burden (r = 0.5; p = 0.011), and worst memory performance (r = ?0.36; p = 0.021). There were no associations with tau pathology (p?values>0.05). Sensitivity analyses were consistent with previous results except for hippocampal volume (r = ?0.4; p = 0.08). Conclusión Findings suggest that NPS captured by MBI?C are associated with pathology and memory in a Colombian kindred with autosomal dominant AD, years before the median age of dementia onset in this cohort. This underscores the importance of behavioral symptoms in preclinical and prodromal ADAD. Follow?up analyses with larger samples and longitudinal assessments are needed to characterize neuropsychiatric symptom evolution as an early marker and target for intervention. Mención de responsabilidad : Daniel Vasquez, David Fernando Aguillon, Ana Y Baena, Stephanie Langella, Diana Munera, Victoria Zubiri, Claudia Ramos, Sergio Alvarez, Martin Ochoa?Escudero, Elizabeth Kaplan, Celina F Pluim McDowell, Jairo E Martinez, Averi Giudicessi, Alex L Badillo?Cabrera, Nikole A Bonillas Félix, Clara Vila?Castelar, Liliana A Ramirez Gomez, Francisco Lopera, Jennifer R Gatchel, Yakeel T Quiroz Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e088002 DOI (Digital Object Identifier) : 10.1002/alz.088002 PMID : 11709999 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11709999/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Associations among mild behavioral impairment symptoms, brain pathology and cognition in individuals with autosomal?dominant Alzheimer’s disease: Findings from the Colombia?Boston (COLBOS) biomarker study [documento electrónico] / Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Vasquez, Daniel, Autor ; Aguillon, David Fernando, Autor ; Baena, Ana Y, Autor ; Langella, Stephanie, Autor ; Munera, Diana, Autor ; Zubiri, Victoria, Autor ; Ramos, Claudia, Autor ; Kaplan, Elizabeth, Autor ; Pluim McDowell, Celina F, Autor ; Martinez, Jairo E, Autor ; Giudicessi, Averi, Autor ; Badillo Cabrera, Alex L, Autor ; Bonillas Félix, Nikole A, Autor ; Vila Castelar, Clara, Autor ; Ramirez Gomez, Liliana A, Autor ; Lopera, Francisco, Autor ; Gatchel, Jennifer R, Autor ; Quiroz, Yakeel T, Autor . - 2025.
Obra : Alzheimers Dement
Idioma : Inglés (eng)
Resumen : Background Neuropsychiatric symptoms (NPS) are common in early stages of Alzheimer’s disease (AD) and may be early markers of cognitive decline and dementia in older individuals. The Mild Behavioral Impairment Checklist (MBI?C) was developed to capture new?onset transdiagnostic NPS in individuals at risk of dementia. We sought to determine whether mild behavioral impairment symptoms are elevated in non?demented Presenilin?1 (PSEN1) E280A carriers, who are genetically determined to develop dementia by their 50s. We hypothesized that those with higher MBI?C total scores would have worse memory performance and greater brain pathology. Method A total of 25 mutation carriers (mean age = 36.3±7.23; 56% females; 18 cognitively?unimpaired, 7 impaired) and 30 non?carriers (70% females) from the Colombia?Boston (COLBOS) Biomarker study were included. All participants completed cognitive testing, the MBI?C (self?reported), and florbetapir (amyloid), flortaucipir (tau) PET, and structural magnetic resonance imaging. We used Mann?Whitney Test to examine group differences, and Spearman’s correlation and linear regression to examine associations among MBI?C total score, Geriatric Depression Scale?15 (GDS), Mini?Mental State Examination (MMSE), CERAD word list learning delayed recall, cortical amyloid burden, regional tau, and hippocampal volume. In sensitivity analyses, we restricted carriers to the 18 unimpaired. Resul MBI?C total scores were similar between carriers and non?carriers (p = 0.09). Compared to non?carriers, carriers had greater amyloid burden (r = 0.55; p = 0.004) and lower hippocampal volume (r = ?0.43; p = 0.034). Among all carriers, higher MBI?C total scores were associated with lower hippocampal volume (r = ?0.44; p = 0.034), greater amyloid burden (r = 0.5; p = 0.011), and worst memory performance (r = ?0.36; p = 0.021). There were no associations with tau pathology (p?values>0.05). Sensitivity analyses were consistent with previous results except for hippocampal volume (r = ?0.4; p = 0.08). Conclusión Findings suggest that NPS captured by MBI?C are associated with pathology and memory in a Colombian kindred with autosomal dominant AD, years before the median age of dementia onset in this cohort. This underscores the importance of behavioral symptoms in preclinical and prodromal ADAD. Follow?up analyses with larger samples and longitudinal assessments are needed to characterize neuropsychiatric symptom evolution as an early marker and target for intervention. Mención de responsabilidad : Daniel Vasquez, David Fernando Aguillon, Ana Y Baena, Stephanie Langella, Diana Munera, Victoria Zubiri, Claudia Ramos, Sergio Alvarez, Martin Ochoa?Escudero, Elizabeth Kaplan, Celina F Pluim McDowell, Jairo E Martinez, Averi Giudicessi, Alex L Badillo?Cabrera, Nikole A Bonillas Félix, Clara Vila?Castelar, Liliana A Ramirez Gomez, Francisco Lopera, Jennifer R Gatchel, Yakeel T Quiroz Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e088002 DOI (Digital Object Identifier) : 10.1002/alz.088002 PMID : 11709999 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11709999/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002374 AC-2025-057 Archivo digital Producción Científica Artículos científicos Disponible Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Tripathi, Vaibhav ; Fox Fuller, Joshua ; Malotaux, Vincent ; Baena, Ana Y ; Bonillas Felix, Nikole ; Aguillon, David Fernando ; Lopera, Francisco ; Somers, David C.
Título : Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease Tipo de documento : texto impreso Autores : Sergio Álvarez Vallejo, Autor ; Tripathi, Vaibhav, Autor ; Fox Fuller, Joshua, Autor ; Malotaux, Vincent, Autor ; Baena, Ana Y, Autor ; Bonillas Felix, Nikole, Autor ; Aguillon, David Fernando, Autor ; Lopera, Francisco, Autor ; Somers, David C., Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : ADAD CPM rsfMRI predictive modeling Resumen : INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-? levels and cognitive scores (word list recall). RESULTS: CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden. DISCUSSION: These results indicate that resting-state functional magnetic resonance imaging (fMRI) methods can complement PET methods in early detection and monitoring of disease progression in ADAD. Highlights: Connectivity-based predictive modeling of tau and amyloid-? in ADAD carriers. Strong predictions for tau deposition; weaker predictions for amyloid-?. Cognitive scores for memory and mental state are predicted strongly. Connectivity between IPL, DAN, DMN, temporal cortex most predictive. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. Mención de responsabilidad : Vaibhav Tripathi, Joshua Fox-Fuller, Vincent Malotaux, Ana Baena, Nikole Bonillas Felix, Sergio Alvarez, David Aguillon, Francisco Lopera, David C. Somers, Yakeel T. Quiroz Referencia : Alzheimer’s Dement. 2025;21:e70061. DOI (Digital Object Identifier) : 10.1002/alz.70061 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70061 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease [texto impreso] / Sergio Álvarez Vallejo, Autor ; Tripathi, Vaibhav, Autor ; Fox Fuller, Joshua, Autor ; Malotaux, Vincent, Autor ; Baena, Ana Y, Autor ; Bonillas Felix, Nikole, Autor ; Aguillon, David Fernando, Autor ; Lopera, Francisco, Autor ; Somers, David C., Autor . - 2025.
Obra : Alzheimer's & Dementia
Idioma : Inglés (eng)
Palabras clave : ADAD CPM rsfMRI predictive modeling Resumen : INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-? levels and cognitive scores (word list recall). RESULTS: CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden. DISCUSSION: These results indicate that resting-state functional magnetic resonance imaging (fMRI) methods can complement PET methods in early detection and monitoring of disease progression in ADAD. Highlights: Connectivity-based predictive modeling of tau and amyloid-? in ADAD carriers. Strong predictions for tau deposition; weaker predictions for amyloid-?. Cognitive scores for memory and mental state are predicted strongly. Connectivity between IPL, DAN, DMN, temporal cortex most predictive. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. Mención de responsabilidad : Vaibhav Tripathi, Joshua Fox-Fuller, Vincent Malotaux, Ana Baena, Nikole Bonillas Felix, Sergio Alvarez, David Aguillon, Francisco Lopera, David C. Somers, Yakeel T. Quiroz Referencia : Alzheimer’s Dement. 2025;21:e70061. DOI (Digital Object Identifier) : 10.1002/alz.70061 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70061 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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