Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia / Sergio Álvarez Vallejo ; Martín Ochoa Escudero ; Kaplan, Elizabeth ; Zuluaga, Yesica ; Vasquez, Daniel ; Hincapie, Liliana ; Aguillon, David Fernando ; Madrigal, Lucia ; Baena, Ana Y ; Vila Castelar, Clara ; Giraldo Chica, Margarita M ; Ramirez Gomez, Liliana A ; Langella, Stephanie ; Arboleda Velasquez, Joseph F ; Lopera, Francisco ; Quiroz, Yakeel T  

Público ISBD Título : Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimers Dement Idioma : Inglés (eng) Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia [documento electrónico] / Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor . - 2025. Obra : Alzheimers Dement Idioma : Inglés (eng) Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Tripathi, Vaibhav ; Fox Fuller, Joshua ; Malotaux, Vincent ; Baena, Ana Y ; Bonillas Felix, Nikole ; Aguillon, David Fernando ; Lopera, Francisco ; Somers, David C.  

Público ISBD Título : Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease Tipo de documento : texto impreso Autores : Sergio Álvarez Vallejo, Autor ; Tripathi, Vaibhav, Autor ; Fox Fuller, Joshua, Autor ; Malotaux, Vincent, Autor ; Baena, Ana Y, Autor ; Bonillas Felix, Nikole, Autor ; Aguillon, David Fernando, Autor ; Lopera, Francisco, Autor ; Somers, David C., Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : ADAD  CPM  rsfMRI  predictive modeling Resumen : INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-? levels and cognitive scores (word list recall). RESULTS: CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden. DISCUSSION: These results indicate that resting-state functional magnetic resonance imaging (fMRI) methods can complement PET methods in early detection and monitoring of disease progression in ADAD. Highlights: Connectivity-based predictive modeling of tau and amyloid-? in ADAD carriers. Strong predictions for tau deposition; weaker predictions for amyloid-?. Cognitive scores for memory and mental state are predicted strongly. Connectivity between IPL, DAN, DMN, temporal cortex most predictive. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. Mención de responsabilidad : Vaibhav Tripathi, Joshua Fox-Fuller, Vincent Malotaux, Ana Baena, Nikole Bonillas Felix, Sergio Alvarez, David Aguillon, Francisco Lopera, David C. Somers, Yakeel T. Quiroz Referencia : Alzheimer’s Dement. 2025;21:e70061. DOI (Digital Object Identifier) : 10.1002/alz.70061 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70061 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease [texto impreso] / Sergio Álvarez Vallejo, Autor ; Tripathi, Vaibhav, Autor ; Fox Fuller, Joshua, Autor ; Malotaux, Vincent, Autor ; Baena, Ana Y, Autor ; Bonillas Felix, Nikole, Autor ; Aguillon, David Fernando, Autor ; Lopera, Francisco, Autor ; Somers, David C., Autor . - 2025. Obra : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : ADAD  CPM  rsfMRI  predictive modeling Resumen : INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-? levels and cognitive scores (word list recall). RESULTS: CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden. DISCUSSION: These results indicate that resting-state functional magnetic resonance imaging (fMRI) methods can complement PET methods in early detection and monitoring of disease progression in ADAD. Highlights: Connectivity-based predictive modeling of tau and amyloid-? in ADAD carriers. Strong predictions for tau deposition; weaker predictions for amyloid-?. Cognitive scores for memory and mental state are predicted strongly. Connectivity between IPL, DAN, DMN, temporal cortex most predictive. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. Mención de responsabilidad : Vaibhav Tripathi, Joshua Fox-Fuller, Vincent Malotaux, Ana Baena, Nikole Bonillas Felix, Sergio Alvarez, David Aguillon, Francisco Lopera, David C. Somers, Yakeel T. Quiroz Referencia : Alzheimer’s Dement. 2025;21:e70061. DOI (Digital Object Identifier) : 10.1002/alz.70061 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70061 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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