Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia [documento electrónico] / Luis Vicente Syro Moreno,  . - 2002.
Obra : Endocrine Pathology

Idioma : Inglés (eng)

Palabras clave :	Prolactin adenoma  pituitary hyperplasia  human  electron microscopy  immunohistochemistry
Resumen :	A 24-yr-old woman with amenorrhea, galactorrhea, hyperprolactinemia, and sellar mass underwent transsphenoidal surgery. Histologic, immunohistochemical, and electron microscopic investigation revealed a well-differentiated, sparsely granulated prolactin (PRL) cell adenoma of the pituitary showing conclusive PRL immunoreactivity. In the nontumorous adenohypophysis PRL cell hyperplasia was noted. Marked differences were evident between the neoplastic and hyperplastic areas. The tumor consisted of sparsely granulated PRL cells immunoreactive only for PRL. As demonstrated by immunoelectron microscopy, the hyperplastic are a comprised monohormonal sparsely granulated PRL cells as well as bihormonal mammosomatotrophs immunoreactive for both PRL and growth hormone. The MIB-1 index was higher whereas microvessel density was lower in the adenoma as compared with the hyperplastic area. In addition, the nontumorous area showed lymphocytic infiltration whereas inflammatory reaction was not seen in the adenoma. This case represents a rare association of a PRL cell adenoma and PRL cell hyperplasia. The fact that these two lesions were contiguous in the surgically removed material raises the possibility that hyperplasia can precede and transform into adenoma.
Mención de responsabilidad :	Sergio Vidal DVM, Eva Horvath PhD, Luis V. Syro MD, Humberto Uribe MD, Sandy Cohen RT & Kalman Kovacs MD, PhD
Referencia :	Endocr Pathol. Summer 2002;13(2):157-65.
DOI (Digital Object Identifier) :	10.1385/EP:13:2:157
PMID :	12165665
En línea :	https://link.springer.com/article/10.1385/EP:13:2:157
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4393