Plurihormonality in pituitary adenomas associated with acromegaly [documento electrónico] / Luis Vicente Syro Moreno,  . - 2006.
Obra : Endocrine Pathology

Idioma : Inglés (eng)

Palabras clave :	Acromegaly  immunohistochemistry  pathology  pituitary adenoma  plurihormonality
Resumen :	Bihormonal or plurihormonal pituitary tumors produce two or more hormones different in chemical composition, immunoreactivity, and clinical significance. Immunohistochemical and electron microscopic investigations and more recently molecular-genetic studies have provided conclusive evidence of the production of multiple hormones by pituitary adenomas. Most frequently, they produce GH, PRL, TSH, and/or alpha-subunit of the g/y-coprotein hormones. Other uncommon combinations may also be apparent. We report the case of a 40-yr-old acromegalic man with a pituitary macrodenoma. The pituitary tumor was removed by transsphenoidal surgery. Histological, immunohistochemical, electron microscopic, and immunoelectron microscopic examinations revealed that the tumor contains multiple hormones (GH, LH, and alpha subunit) and transcription factors. The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated.
Mención de responsabilidad :	Fateme Salehi BSc, Sandra Cohen MLT, Luis V. Syro MD, Humberto Uribe MD, Eva Horvath PhD, Kalman Kovacs MD, PhD & Sylvia L. Asa MD, PhD
Referencia :	Endocr Pathol. Fall 2006;17(3):291-6.
DOI (Digital Object Identifier) :	10.1385/EP:17:3:291
PMID :	17308366
En línea :	https://link.springer.com/article/10.1385%2FEP%3A17%3A3%3A291
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4417