| Título : |
Infections of the central nervous system by Candida |
| Tipo de documento : |
documento electrónico |
| Autores : |
Basilio Vagner Ramírez, |
| Fecha de publicación : |
2011 |
| Títulos uniformes : |
Journal of Infectious Diseases and Immunity
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
Candida central nervous system infections |
| Resumen : |
At present, the species of Candida are the increasing causes of infections in neutropenic and non neutropenic patients, and they enable the production of important morbimortality. Invasive candidiasis is the most frequent opportunistic mycosis and when there is central nervous system (CNS) involvement, mortality associated to mycosis increase. Unfortunately, studies based in autopsies prove that the prevalence of CNS disease by fungi is undervalued in clinical practice. The clinical presentation includes meningitis, microabscesses, macroabscesses, vascular and medullar injury. The initial symptoms of acute meningitis by Candida are indistinguishable from those produced by bacterial infection and its diagnosis requires a high level of suspicion in the cases of isolation of Candida in cerebrospinal fluid (CSF), in any sterile liquid in patients with pleocytosis in the CSF or in blood cultures and when there is no improvement of clinical condition in spite of proper treatment. Clinical evidence, although limited, suggests that the combination of antifungals produces faster CSF sterilization when compared to mono-therapy. Regrettably, in spite of appropriate treatment, the mortality associated with this entity is of 10 to 30% and the percentage of neurological sequels goes from 18 to 29% which highlights the importance of timely recognition and management of Candida related CNS infections. |
| Mención de responsabilidad : |
Natalia Aristizabal Henao and Basilio Vagner |
| DOI (Digital Object Identifier) : |
10.5897/JIDI.9000024 |
| Derechos de uso : |
CC BY |
| En línea : |
https://academicjournals.org/journal/JIDI/article-abstract/98E16F23669 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4883 |
Infections of the central nervous system by Candida [documento electrónico] / Basilio Vagner Ramírez, . - 2011. Obra : Journal of Infectious Diseases and ImmunityIdioma : Inglés ( eng) | Palabras clave : |
Candida central nervous system infections |
| Resumen : |
At present, the species of Candida are the increasing causes of infections in neutropenic and non neutropenic patients, and they enable the production of important morbimortality. Invasive candidiasis is the most frequent opportunistic mycosis and when there is central nervous system (CNS) involvement, mortality associated to mycosis increase. Unfortunately, studies based in autopsies prove that the prevalence of CNS disease by fungi is undervalued in clinical practice. The clinical presentation includes meningitis, microabscesses, macroabscesses, vascular and medullar injury. The initial symptoms of acute meningitis by Candida are indistinguishable from those produced by bacterial infection and its diagnosis requires a high level of suspicion in the cases of isolation of Candida in cerebrospinal fluid (CSF), in any sterile liquid in patients with pleocytosis in the CSF or in blood cultures and when there is no improvement of clinical condition in spite of proper treatment. Clinical evidence, although limited, suggests that the combination of antifungals produces faster CSF sterilization when compared to mono-therapy. Regrettably, in spite of appropriate treatment, the mortality associated with this entity is of 10 to 30% and the percentage of neurological sequels goes from 18 to 29% which highlights the importance of timely recognition and management of Candida related CNS infections. |
| Mención de responsabilidad : |
Natalia Aristizabal Henao and Basilio Vagner |
| DOI (Digital Object Identifier) : |
10.5897/JIDI.9000024 |
| Derechos de uso : |
CC BY |
| En línea : |
https://academicjournals.org/journal/JIDI/article-abstract/98E16F23669 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4883 |
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