| Título : |
Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study |
| Tipo de documento : |
documento electrónico |
| Autores : |
Alejandro Díaz Díaz, Autor ; Sossa Alarcón, María Camila, Autor ; Gutiérrez, Mónica Paola, Autor ; Becerra, Natalia, Autor ; Ortegon, Luz Yessenia, Autor ; David, María Camila, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Piñeros, Juan Gabriel, Autor ; Restrepo Gualteros, Sonia, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez Tobar, Iván, Autor ; Camilo Mesa, Andrés, Autor ; Bachiller Tuta, William Ricardo, Autor ; Galvis Diaz, Clara Esperanza, Autor ; Africano, Martha, Autor ; Nieto, José Manuel, Autor ; Pérez Camacho, Paola Marsela, Autor ; Beltrán Arroyave, Claudia, Autor ; Vivas Trochez, Rosalba, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Herrero, Blanca, Autor ; Calleja, Lourdes, Autor ; Grasa, Carlos, Autor ; Rodriguez, Paula, Autor ; Melendo, Susana, Autor ; Soriano Arandes, Antoni, Autor ; Gómez Pastrana, Irene, Autor ; García García, Sonsoles, Autor ; Fumado, Victoria, Autor ; Ramirez Varela, Andrea, Autor |
| Fecha de publicación : |
2025 |
| Títulos uniformes : |
International Journal of Collaborative Research on Internal Medicine & Public Health
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
COVID-19 pediatrics inpatients cluster analysis SARS-CoV-2 variants |
| Resumen : |
Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. |
| Mención de responsabilidad : |
María Camila Sossa-Alarcón1*†, Mónica Paola Gutiérrez1†, Natalia Becerra1†,Luz Yessenia Ortegon1†, María Camila David1†,Melisa Naranjo vanegas2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, Gabriela Friedrich 2,Pablo Vásquez-Hoyos3, María Lucía Mesa-Rubio1,Luis Miguel Navarro-Ramirez2Sergio Moreno-Lopez2, Olga Lucía Baquero4, Luz Marina Mejía5, Juan Gabriel Piñeros1,Sonia Restrepo-Gualteros1, Carlos Álvarez-Moreno6, Alejandro Díaz-Díaz7, Iván Gutierrez-Tobar8, Andrés Camilo Mesa9, William Ricardo Bachiller Tuta10,Clara Esperanza Galvis Diaz11, Martha Africano12, José Manuel Nieto13,Paola Marcela Pérez Camacho14, Claudia Beltrán-Arroyave15, Rosalba Vivas Trochez16,Irati Gastesi17, Cinta Moraleda17, Alfredo Tagarro García17,18, Blanca Herrero19,Lourdes Calleja19, Carlos Grasa20, Paula Rodriguez20, Susana Melendo21,Antoni Soriano-Arandes21, Irene Gómez Pastrana17, Sonsoles García García17,Victoria Fumado22 and Andrea Ramírez Varela23 on behalf of EPICO-Colombia and EPICO-AEP |
| Referencia : |
Int J Public Health. 2025 Mar 18;70:1607246 |
| DOI (Digital Object Identifier) : |
10.3389/ijph.2025.1607246 |
| PMID : |
40170693 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://pmc.ncbi.nlm.nih.gov/articles/PMC11959304/ |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study [documento electrónico] / Alejandro Díaz Díaz, Autor ; Sossa Alarcón, María Camila, Autor ; Gutiérrez, Mónica Paola, Autor ; Becerra, Natalia, Autor ; Ortegon, Luz Yessenia, Autor ; David, María Camila, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Piñeros, Juan Gabriel, Autor ; Restrepo Gualteros, Sonia, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez Tobar, Iván, Autor ; Camilo Mesa, Andrés, Autor ; Bachiller Tuta, William Ricardo, Autor ; Galvis Diaz, Clara Esperanza, Autor ; Africano, Martha, Autor ; Nieto, José Manuel, Autor ; Pérez Camacho, Paola Marsela, Autor ; Beltrán Arroyave, Claudia, Autor ; Vivas Trochez, Rosalba, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Herrero, Blanca, Autor ; Calleja, Lourdes, Autor ; Grasa, Carlos, Autor ; Rodriguez, Paula, Autor ; Melendo, Susana, Autor ; Soriano Arandes, Antoni, Autor ; Gómez Pastrana, Irene, Autor ; García García, Sonsoles, Autor ; Fumado, Victoria, Autor ; Ramirez Varela, Andrea, Autor . - 2025. Obra : International Journal of Collaborative Research on Internal Medicine & Public HealthIdioma : Inglés ( eng)
| Palabras clave : |
COVID-19 pediatrics inpatients cluster analysis SARS-CoV-2 variants |
| Resumen : |
Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. |
| Mención de responsabilidad : |
María Camila Sossa-Alarcón1*†, Mónica Paola Gutiérrez1†, Natalia Becerra1†,Luz Yessenia Ortegon1†, María Camila David1†,Melisa Naranjo vanegas2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, Gabriela Friedrich 2,Pablo Vásquez-Hoyos3, María Lucía Mesa-Rubio1,Luis Miguel Navarro-Ramirez2Sergio Moreno-Lopez2, Olga Lucía Baquero4, Luz Marina Mejía5, Juan Gabriel Piñeros1,Sonia Restrepo-Gualteros1, Carlos Álvarez-Moreno6, Alejandro Díaz-Díaz7, Iván Gutierrez-Tobar8, Andrés Camilo Mesa9, William Ricardo Bachiller Tuta10,Clara Esperanza Galvis Diaz11, Martha Africano12, José Manuel Nieto13,Paola Marcela Pérez Camacho14, Claudia Beltrán-Arroyave15, Rosalba Vivas Trochez16,Irati Gastesi17, Cinta Moraleda17, Alfredo Tagarro García17,18, Blanca Herrero19,Lourdes Calleja19, Carlos Grasa20, Paula Rodriguez20, Susana Melendo21,Antoni Soriano-Arandes21, Irene Gómez Pastrana17, Sonsoles García García17,Victoria Fumado22 and Andrea Ramírez Varela23 on behalf of EPICO-Colombia and EPICO-AEP |
| Referencia : |
Int J Public Health. 2025 Mar 18;70:1607246 |
| DOI (Digital Object Identifier) : |
10.3389/ijph.2025.1607246 |
| PMID : |
40170693 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://pmc.ncbi.nlm.nih.gov/articles/PMC11959304/ |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Clasificado(s) por (Año de edición descendente) Refinar búsquedaPhenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study / Alejandro Díaz Díaz ; Sossa Alarcón, María Camila ; Gutiérrez, Mónica Paola ; Becerra, Natalia ; Ortegon, Luz Yessenia ; David, María Camila ; Naranjo Vanegas, Melisa ; Friedrich, Gabriela ; Vásquez Hoyos, Pablo ; Mesa Rubio, María Lucía ; Navarro Ramirez, Luis Miguel ; Moreno Lopez, Sergio ; Baquero, Olga Lucía ; Marina Mejía, Luz ; Piñeros, Juan Gabriel ; Restrepo Gualteros, Sonia ; Álvarez Moreno, Carlos ; Gutierrez Tobar, Iván ; Camilo Mesa, Andrés ; Bachiller Tuta, William Ricardo ; Galvis Diaz, Clara Esperanza ; Africano, Martha ; Nieto, José Manuel ; Pérez Camacho, Paola Marsela ; Beltrán Arroyave, Claudia ; Vivas Trochez, Rosalba ; Gastesi, Irati ; Moraleda, Cinta ; Tagarro García, Alfredo ; Herrero, Blanca ; Calleja, Lourdes ; Grasa, Carlos ; Rodriguez, Paula ; Melendo, Susana ; Soriano Arandes, Antoni ; Gómez Pastrana, Irene ; García García, Sonsoles ; Fumado, Victoria ; Ramirez Varela, Andrea
