Positive culture and prognosis in patients with sepsis: a prospective cohort study [documento electrónico] / Fabián Alberto Jaimes Barragán,  . - 2020.
Obra : Journal of Intensive Care Medicine

Idioma : Inglés (eng)

Palabras clave :	Blood culture  epidemiology  microbiological culture  mortality  sepsis
Resumen :	Purpose: To analyze the prognostic role of positive cultures in patients with sepsis. Methods: A prospective cohort study in a tertiary referral hospital in Medellín, Colombia. Adults older than 18 years of age with a bacterial infection diagnosis according to Centers for Disease Control criteria and sepsis (evidence of organ dysfunction) were included. A logistic regression model was used to determine the association between positive cultures and hospital mortality, and a Cox regression with a competing risk modeling approach was used to determine the association between positive cultures and hospital stay as well as secondary infections. Results: Overall, 408 patients had positive cultures, of which 257 were blood culture, and 153 had negative cultures. Patients with positive cultures had a lower risk of mortality (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.27-0.68), but this association was not maintained after adjusting for confounding factors (OR, 0.56; 95% CI, 0.31-1.01). No association was found with the hospital stay (adjusted subhazard ratio [SHR], 1.06; 95% CI, 0.83-1.35). There was no association between positive cultures and the presence of secondary infections (adjusted SHR, 0.99; 95% CI, 0.58-1.71). Conclusion: Positive cultures are not associated with prognosis in patients with sepsis.
Mención de responsabilidad :	Fernando Molina, Pablo Castaño, Maribel Plaza, Carolina Hincapié, Wilmar Maya, Juan Carlos Cataño, Javier González, Alba León, Fabián Jaimes
Referencia :	J Intensive Care Med. 2020 Aug;35(8):755-762.
DOI (Digital Object Identifier) :	10.1177/0885066618783656
PMID :	29925284
En línea :	https://journals.sagepub.com/doi/abs/10.1177/0885066618783656?journalCode=jica
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4696