| Título : |
Determination of the 99th percentile of anticardiolipin and anti-?2 glycoprotein I antibodies in an institution in the city of Medellin, Colombia |
| Otros títulos : |
Determinación del percentil 99 de los anticuerpos anticardiolipina y anti-?2 glicoproteína I en una institución en la ciudad de Medellín, Colombia |
| Tipo de documento : |
documento electrónico |
| Autores : |
Sergio Jaramillo Velásquez, Autor ; Castilla Agudelo, Gustavo Adolfo, Autor ; Rodríguez Padilla, Libia María, Autor ; Lady Johanna Hernández Zapata, Autor ; Mesa Navas, Miguel Antonio, Autor ; María Fernanda Álvarez Barreneche, Autor ; Carlos Jaime Velásquez Franco, Autor |
| Fecha de publicación : |
2024 |
| Títulos uniformes : |
Revista Colombiana de Reumatología
|
| Idioma : |
Inglés (eng) Idioma original : Español (spa) |
| Resumen : |
Introduction Antiphospholipid syndrome diagnosis requires abnormal results of lupus anticoagulant and high titles of anticardiolipin (aCL) and ?2glycoprotein I (anti-?2GPI) antibodies. The latter immunological tests lack a standard threshold in clinical practice. Objective To determine the 99th percentile of aCL and anti-?2GPI in healthy volunteers. Materials and methods This cross-sectional study reviewed antibody titles of anticardiolipin and ?2glycoprotein I (IgG and IgM by enzyme-linked immunosorbent assay) in forty-nine healthy blood donors in Medellin, Colombia. Sociodemographic and immunological variables are also assessed. Antibody titles are described in median and interquartile range and the 99th percentile was estimated. Results We analysed samples from 16 men and 33 women. We found that the upper limits of the reference range (99th percentile) of aCL and anti-?2GPI were: aCL IgM: 18.0, aCL IgG: 16.1, anti-?2GPI IgM: 16.4, and anti- ?2GPI IgG: 6.9. Conclusions The upper limits obtained differ greatly from the arbitrary classification values suggested in the international guidelines, taking into account that values greater than 40 international units are usually required, and the values identified in this study are between 6.9 and 18 international units. We suggest conducting additional studies that validate cut-off points according to the percentiles explored in this work. |
| Mención de responsabilidad : |
"Gustavo Adolfo Castilla Agudelo a b , Libia María Rodríguez Padilla b c , Sergio Jaramillo Velásquez d , Lady Johanna Hernández Zapata b e , Miguel Antonio Mesa Navas b c f , María Fernanda Álvarez Barreneche b g , Carlos Jaime Velásquez Franco" |
| Referencia : |
Volume 31, Issue 1, January–March 2024, Pages 3-10 |
| DOI (Digital Object Identifier) : |
10.1016/j.rcreue.2022.01.003 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/abs/pii/S2444440524000190 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Determination of the 99th percentile of anticardiolipin and anti-?2 glycoprotein I antibodies in an institution in the city of Medellin, Colombia = Determinación del percentil 99 de los anticuerpos anticardiolipina y anti-?2 glicoproteína I en una institución en la ciudad de Medellín, Colombia [documento electrónico] / Sergio Jaramillo Velásquez, Autor ; Castilla Agudelo, Gustavo Adolfo, Autor ; Rodríguez Padilla, Libia María, Autor ; Lady Johanna Hernández Zapata, Autor ; Mesa Navas, Miguel Antonio, Autor ; María Fernanda Álvarez Barreneche, Autor ; Carlos Jaime Velásquez Franco, Autor . - 2024. Obra : Revista Colombiana de ReumatologíaIdioma : Inglés ( eng) Idioma original : Español ( spa)
| Resumen : |
Introduction Antiphospholipid syndrome diagnosis requires abnormal results of lupus anticoagulant and high titles of anticardiolipin (aCL) and ?2glycoprotein I (anti-?2GPI) antibodies. The latter immunological tests lack a standard threshold in clinical practice. Objective To determine the 99th percentile of aCL and anti-?2GPI in healthy volunteers. Materials and methods This cross-sectional study reviewed antibody titles of anticardiolipin and ?2glycoprotein I (IgG and IgM by enzyme-linked immunosorbent assay) in forty-nine healthy blood donors in Medellin, Colombia. Sociodemographic and immunological variables are also assessed. Antibody titles are described in median and interquartile range and the 99th percentile was estimated. Results We analysed samples from 16 men and 33 women. We found that the upper limits of the reference range (99th percentile) of aCL and anti-?2GPI were: aCL IgM: 18.0, aCL IgG: 16.1, anti-?2GPI IgM: 16.4, and anti- ?2GPI IgG: 6.9. Conclusions The upper limits obtained differ greatly from the arbitrary classification values suggested in the international guidelines, taking into account that values greater than 40 international units are usually required, and the values identified in this study are between 6.9 and 18 international units. We suggest conducting additional studies that validate cut-off points according to the percentiles explored in this work. |
| Mención de responsabilidad : |
"Gustavo Adolfo Castilla Agudelo a b , Libia María Rodríguez Padilla b c , Sergio Jaramillo Velásquez d , Lady Johanna Hernández Zapata b e , Miguel Antonio Mesa Navas b c f , María Fernanda Álvarez Barreneche b g , Carlos Jaime Velásquez Franco" |
| Referencia : |
Volume 31, Issue 1, January–March 2024, Pages 3-10 |
| DOI (Digital Object Identifier) : |
10.1016/j.rcreue.2022.01.003 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/abs/pii/S2444440524000190 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
|  |
Inicio
Clasificado(s) por (Año de edición descendente) Refinar búsquedaDetermination of the 99th percentile of anticardiolipin and anti-?2 glycoprotein I antibodies in an institution in the city of Medellin, Colombia / Sergio Jaramillo Velásquez ; Castilla Agudelo, Gustavo Adolfo ; Rodríguez Padilla, Libia María ; Lady Johanna Hernández Zapata ; Mesa Navas, Miguel Antonio ; María Fernanda Álvarez Barreneche ; Carlos Jaime Velásquez Franco
