| Título : |
Diferencia estandarizada de las características basales de los ensayos clínicos: Estudio metaepidemiológico. |
| Tipo de documento : |
documento electrónico |
| Autores : |
Jorge Hernando Donado Gómez, Autor ; Durango Villada, Laura, Autor ; Giraldo Echeverri, Luz María, Autor ; Buitrago Bach, Ricardo, Autor |
| Fecha de publicación : |
2025 |
| Títulos uniformes : |
Salud Uninorte
|
| Idioma : |
Español (spa) |
| Palabras clave : |
MEDICAL periodicals; RANDOMIZED controlled trials; CLINICAL trials; SAMPLE size (Statistics); SOCIAL factors |
| Resumen : |
Objective: Establish the difference between standardized mean for quantitative and qualitative variables, exploring its impact in randomized controlled clinical trials based on their sample size. Methodology: Observational, meta-epidemiological study. Inclusion criteria involved parallel-group clinical trials published between January 2021 and August 2022 in four major medical journals worldwide. The exclusion criteria were the participation in clinical trials with more than two groups or arms. Results: It was observed that 99 % of the studies included demographic variables (age, sex, race, or ethnicity), 98 % clinical variables, 45 % treatment-related variables, and 23 % social variables (educational level, marital status). In the analysis of the standardized difference according to sample size, it was found that this value decreased as the number of participants increased, with a mean of 0,12 for the group with fewer than 500 participants and 0,02 for those groups with more than 2000 participants. Conclusions: Studies with larger sample sizes exhibit a tinier standardized mean difference, showing a tendency to be inversely proportional. This finding suggests the importance of considering the sample size when interpreting the results of clinical trials, highlighting the relevance of the consistency and applicability of the findings in studies with extensive numbers of participants. |
| Mención de responsabilidad : |
DURANGO VILLADA, LAURA; GIRALDO ECHEVERRI, LUZ MARÍA; BUITRAGO BACH, RICARDO; DONADO GÓMEZ, JORGE HERNANDO |
| DOI (Digital Object Identifier) : |
10.14482/sun.41.02.484.070 |
| Derechos de uso : |
CC BY-NC-ND |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Diferencia estandarizada de las características basales de los ensayos clínicos: Estudio metaepidemiológico. [documento electrónico] / Jorge Hernando Donado Gómez, Autor ; Durango Villada, Laura, Autor ; Giraldo Echeverri, Luz María, Autor ; Buitrago Bach, Ricardo, Autor . - 2025. Obra : Salud UninorteIdioma : Español ( spa)
| Palabras clave : |
MEDICAL periodicals; RANDOMIZED controlled trials; CLINICAL trials; SAMPLE size (Statistics); SOCIAL factors |
| Resumen : |
Objective: Establish the difference between standardized mean for quantitative and qualitative variables, exploring its impact in randomized controlled clinical trials based on their sample size. Methodology: Observational, meta-epidemiological study. Inclusion criteria involved parallel-group clinical trials published between January 2021 and August 2022 in four major medical journals worldwide. The exclusion criteria were the participation in clinical trials with more than two groups or arms. Results: It was observed that 99 % of the studies included demographic variables (age, sex, race, or ethnicity), 98 % clinical variables, 45 % treatment-related variables, and 23 % social variables (educational level, marital status). In the analysis of the standardized difference according to sample size, it was found that this value decreased as the number of participants increased, with a mean of 0,12 for the group with fewer than 500 participants and 0,02 for those groups with more than 2000 participants. Conclusions: Studies with larger sample sizes exhibit a tinier standardized mean difference, showing a tendency to be inversely proportional. This finding suggests the importance of considering the sample size when interpreting the results of clinical trials, highlighting the relevance of the consistency and applicability of the findings in studies with extensive numbers of participants. |
| Mención de responsabilidad : |
DURANGO VILLADA, LAURA; GIRALDO ECHEVERRI, LUZ MARÍA; BUITRAGO BACH, RICARDO; DONADO GÓMEZ, JORGE HERNANDO |
| DOI (Digital Object Identifier) : |
10.14482/sun.41.02.484.070 |
| Derechos de uso : |
CC BY-NC-ND |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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