Immunosupressive therapy in children with steroid-resistant nephrotic syndrome: single center experience [documento electrónico] / Catalina Vélez Echeverri, ; Gustavo Adolfo Zuluaga Valencia, ; Lina Maria Serna Higuita, ; John Jairo Zuleta Tobón, ; Juan José Vanegas Ruiz,  . - 2013.
Obra : Brazilian Journal of Nephrology

Idioma : Inglés (eng)

Palabras clave :	Immunosuppressive Agents  Chronic Kidney Failure  mycophenolic acid  Nephrotic Syndrome
Resumen :	INTRODUCTION: Nephrotic syndrome is one of the most frequent glomerular diseases among children, and steroid therapy remains as the treatment choice. In spite of this, 10 to 15% of the patients are steroidresistant, and the best therapy for such cases has never been defined. Mycophenolate acid (MA) is one of the treatments used in such situations. OBJECTIVE: To describe the clinical behavior of children diagnosed with steroid-resistant nephrotic syndrome (SRNS) and to assess the therapeutic response to MA. METHODS: This was a retrospective and descriptive study. RESULTS: 26 clinical records of patients with SRNS; 70% male and 30% female. All patients underwent kidney biopsies, which showed a predominance of focal segmental glomerulosclerosis (FSGS). The immunosuppresive drugs used were: Mycophenolate mofetil (MMF) 100%, Cyclosporine 69.2%, Cyclophosphamide 23.1%, and Rituximab 23%. One month after treatment initiation with MMF 61.5% achieved remission. The median of relapses per year for the patients was 3 (p25: 2.75 – p75: 4). This median became 1 (p25: 1 – p75: 3.25) after using this medication (p = 0.08). Furthermore, prior to the start of the MMF treatment, the median of the steroid dose was 1 (p25: 0.5- p75: 1.62) mg/k/day. After using MMF, this median became 0.07 (p25: 0 – p75: 0.55) mg/k/day (p
Mención de responsabilidad :	Catalina Velez Echeverri, Gustavo Adolfo Zuluaga Valencia, Lina Maria Serna Higuita, Ana Katherina Serrano Gayubo, Carolina Lucia Ochoa, Luisa Fernanda Rojas Rosas, Laura Carolina Muñoz, Javier Sierra, Jhon Jairo Zuleta, Juan José Vanegas Ruiz
Referencia :	J Bras Nefrol. Jul-Sep 2013;35(3):200-5.
DOI (Digital Object Identifier) :	10.5935/0101-2800.20130032
PMID :	24100739
Derechos de uso :	CC BY
En línea :	https://bjnephrology.org/en/article/immunosupressive-therapy-in-children-with-st [...]
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