| Título : |
Cytokine release syndrome after haploidentical hematopoietic cell transplantation: an international multicenter analysis |
| Tipo de documento : |
documento electrónico |
| Autores : |
Marcos Arango Barrientos, |
| Fecha de publicación : |
2021 |
| Títulos uniformes : |
Bone Marrow Transplantation
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Haploidentical related donor transplantation (haplo-HCT) is associated with cytokine release syndrome (CRS). We conducted a multicenter retrospective study to analyze risk factors for CRS and outcomes after haplo-HCT. We included 451 patients from four academic centers receiving both peripheral blood and bone marrow grafts. Severe CRS was more common with PB vs. BM grafts (19.5% vs 4.9%, OR 2.9, p = 0.05). Multivariable analysis identified recipient CMV sero-positivity, prior transplant, HCT-CI score and donor–recipient sex mismatch as risk factors for severe CRS. Outcomes were analyzed with no CRS as the comparison group. Overall survival (OS) was superior with mild CRS (HR 0.64, p = 0.05) and worst with severe CRS (HR 2.12, p = 0.0038). Relapse risk was significantly decreased in both mild CRS (HR 0.38, p |
| Mención de responsabilidad : |
Ramzi Abboud, Fei Wan, Jacopo Mariotti, Marcos Arango, Luca Castagna, Rizwan Romee, Mehdi Hamadani & Saurabh Chhabra |
| Referencia : |
Bone Marrow Transplant. 2021 Nov;56(11):2763-2770. |
| DOI (Digital Object Identifier) : |
10.1038/s41409-021-01403-w |
| PMID : |
34262142 |
| En línea : |
https://www.nature.com/articles/s41409-021-01403-w |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5810 |
Cytokine release syndrome after haploidentical hematopoietic cell transplantation: an international multicenter analysis [documento electrónico] / Marcos Arango Barrientos, . - 2021. Obra : Bone Marrow TransplantationIdioma : Inglés ( eng) | Resumen : |
Haploidentical related donor transplantation (haplo-HCT) is associated with cytokine release syndrome (CRS). We conducted a multicenter retrospective study to analyze risk factors for CRS and outcomes after haplo-HCT. We included 451 patients from four academic centers receiving both peripheral blood and bone marrow grafts. Severe CRS was more common with PB vs. BM grafts (19.5% vs 4.9%, OR 2.9, p = 0.05). Multivariable analysis identified recipient CMV sero-positivity, prior transplant, HCT-CI score and donor–recipient sex mismatch as risk factors for severe CRS. Outcomes were analyzed with no CRS as the comparison group. Overall survival (OS) was superior with mild CRS (HR 0.64, p = 0.05) and worst with severe CRS (HR 2.12, p = 0.0038). Relapse risk was significantly decreased in both mild CRS (HR 0.38, p |
| Mención de responsabilidad : |
Ramzi Abboud, Fei Wan, Jacopo Mariotti, Marcos Arango, Luca Castagna, Rizwan Romee, Mehdi Hamadani & Saurabh Chhabra |
| Referencia : |
Bone Marrow Transplant. 2021 Nov;56(11):2763-2770. |
| DOI (Digital Object Identifier) : |
10.1038/s41409-021-01403-w |
| PMID : |
34262142 |
| En línea : |
https://www.nature.com/articles/s41409-021-01403-w |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5810 |
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