| Título : |
Musclin is related to insulin resistance and body composition, but not to body mass index or cardiorespiratory capacity in adults |
| Tipo de documento : |
documento electrónico |
| Autores : |
Mauricio Estrada Castrillón, |
| Fecha de publicación : |
2021 |
| Títulos uniformes : |
Endocrinology and Metabolism
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
Hormones Musclin protein human (OSTN) Metabolic syndrome Insulin resistance Muscle skeletal Body composition |
| Resumen : |
Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P |
| Mención de responsabilidad : |
Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón |
| Referencia : |
Endocrinol Metab (Seoul). 2021 Oct;36(5):1055-1068. |
| DOI (Digital Object Identifier) : |
10.3803/EnM.2021.1104 |
| PMID : |
34674511 |
| Derechos de uso : |
CC BY-NC |
| En línea : |
https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.1104 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5850 |
Musclin is related to insulin resistance and body composition, but not to body mass index or cardiorespiratory capacity in adults [documento electrónico] / Mauricio Estrada Castrillón, . - 2021. Obra : Endocrinology and MetabolismIdioma : Inglés ( eng) | Palabras clave : |
Hormones Musclin protein human (OSTN) Metabolic syndrome Insulin resistance Muscle skeletal Body composition |
| Resumen : |
Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P |
| Mención de responsabilidad : |
Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón |
| Referencia : |
Endocrinol Metab (Seoul). 2021 Oct;36(5):1055-1068. |
| DOI (Digital Object Identifier) : |
10.3803/EnM.2021.1104 |
| PMID : |
34674511 |
| Derechos de uso : |
CC BY-NC |
| En línea : |
https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.1104 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5850 |
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