Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury / Juan Camilo Jaramillo Bustamante ; Chong, Shu Ling ; Zhu, Yanan ; Wang, Quan ; Caporal, Paula ; Roa, Juan D ; Pantoja Chamorro, Freddy Israel ; Teran Miranda, Thelma Elvira ; Dang, Hongxing ; Seng Gan, Chin ; Abbas, Qalab ; Ardila, Ivan J ; Antar, Mohannad Ahmad ; Domínguez Rojas, Jesús A ; Miñambres Rodríguez, María ; Zita Watzlawik, Natalia ; Gómez Arriola, Natalia Elizabeth ; Yock Corrales, Adriana ; Lasso Palomino, Rubén Eduardo ; Mei Xiu, Ming ; S M Ong, Jacqueline ; Kurosawa, Hiroshi ; Aparicio, Gabriela ; Chunfeng Liu ; Rujipat, Samransamruajkit ; Nattachai, Anantasit ; Yek Kee Chor ; Turina, Deborah M ; Pei Chuen Lee ; Fonseca Flores, Marisol ; Pilar Orive, Francisco Javier ; Pei Wen, Jane Ng ; González Dambrauskas, Sebastián ; Lee, Jan Hau  

Público ISBD Título : Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury Tipo de documento : documento electrónico Autores : Juan Camilo Jaramillo Bustamante, Autor ; Chong, Shu Ling, Autor ; Zhu, Yanan, Autor ; Wang, Quan, Autor ; Caporal, Paula, Autor ; Roa, Juan D, Autor ; Pantoja Chamorro, Freddy Israel, Autor ; Teran Miranda, Thelma Elvira, Autor ; Dang, Hongxing, Autor ; Seng Gan, Chin, Autor ; Abbas, Qalab, Autor ; Ardila, Ivan J, Autor ; Antar, Mohannad Ahmad, Autor ; Domínguez Rojas, Jesús A, Autor ; Miñambres Rodríguez, María, Autor ; Zita Watzlawik, Natalia, Autor ; Gómez Arriola, Natalia Elizabeth, Autor ; Yock Corrales, Adriana, Autor ; Lasso Palomino, Rubén Eduardo, Autor ; Mei Xiu, Ming, Autor ; S M Ong, Jacqueline, Autor ; Kurosawa, Hiroshi, Autor ; Aparicio, Gabriela, Autor ; Chunfeng Liu, Autor ; Rujipat, Samransamruajkit, Autor ; Nattachai, Anantasit, Autor ; Yek Kee Chor, Autor ; Turina, Deborah M, Autor ; Pei Chuen Lee, Autor ; Fonseca Flores, Marisol, Autor ; Pilar Orive, Francisco Javier, Autor ; Pei Wen, Jane Ng, Autor ; González Dambrauskas, Sebastián, Autor ; Lee, Jan Hau, Autor Fecha de publicación : 2025 Títulos uniformes : JAMA Network Open Idioma : Inglés (eng) Resumen : Importance: The use of hypertonic saline (HTS) vs mannitol in the control of elevated intracranial pressure (ICP) secondary to neurotrauma is debated. Objective: To compare mortality and functional outcomes of treatment with 3% HTS vs 20% mannitol among children with moderate to severe traumatic brain injury (TBI) at risk of elevated ICP. Design, setting, and participants: This prospective, multicenter cohort study was conducted between June 1, 2018, and December 31, 2022, at 28 participating pediatric intensive care units in the Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) and the Red Colaborativa Pediátrica de Latinoamérica (LARed) in Asia, Latin America, and Europe. The study included children (aged Mención de responsabilidad : Shu-Ling Chong, MD, MPH; Yanan Zhu, PhD; Quan Wang, MD; Paula Caporal, MPH; Juan D. Roa, MD; Freddy Israel Pantoja Chamorro, MD;Thelma Elvira Teran Miranda, MD; Hongxing Dang, MD; Chin Seng Gan, MD; Qalab Abbas, MD; Ivan J. Ardila, MD; Mohannad Ahmad Antar, MD;Jesús A. Domínguez-Rojas, MD; María Miñambres Rodríguez, PhD; Natalia Zita Watzlawik, MD; Natalia Elizabeth Gómez Arriola, MD; Adriana Yock-Corrales, MD;Rubén Eduardo Lasso-Palomino, MD; Ming Mei Xiu, MD; Jacqueline S. M. Ong, MD; Hiroshi Kurosawa, MD; Gabriela Aparicio, MD; Chunfeng Liu, MD;Rujipat Samransamruajkit, MD; Juan C. Jaramillo-Bustamante, MD; Nattachai Anantasit, MD; Yek Kee Chor, MD; Deborah M. Turina, MD; Pei Chuen Lee, MD;Marisol Fonseca Flores, MD; Francisco Javier Pilar Orive, PhD; Jane Ng Pei Wen, BSc; Sebastián González-Dambrauskas, MD; Jan Hau Lee, MCI;for the Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) and the Red Colaborativa Pediátrica de Latinoamérica (LARed) Referencia : JAMA Netw Open . 2025 Mar 3;8(3):e250438. DOI (Digital Object Identifier) : 10.1001/jamanetworkopen.2025.0438. PMID : 40067302 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40067302/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury [documento electrónico] / Juan Camilo Jaramillo Bustamante, Autor ; Chong, Shu Ling, Autor ; Zhu, Yanan, Autor ; Wang, Quan, Autor ; Caporal, Paula, Autor ; Roa, Juan D, Autor ; Pantoja Chamorro, Freddy Israel, Autor ; Teran Miranda, Thelma Elvira, Autor ; Dang, Hongxing, Autor ; Seng Gan, Chin, Autor ; Abbas, Qalab, Autor ; Ardila, Ivan J, Autor ; Antar, Mohannad Ahmad, Autor ; Domínguez Rojas, Jesús A, Autor ; Miñambres Rodríguez, María, Autor ; Zita Watzlawik, Natalia, Autor ; Gómez Arriola, Natalia Elizabeth, Autor ; Yock Corrales, Adriana, Autor ; Lasso Palomino, Rubén Eduardo, Autor ; Mei Xiu, Ming, Autor ; S M Ong, Jacqueline, Autor ; Kurosawa, Hiroshi, Autor ; Aparicio, Gabriela, Autor ; Chunfeng Liu, Autor ; Rujipat, Samransamruajkit, Autor ; Nattachai, Anantasit, Autor ; Yek Kee Chor, Autor ; Turina, Deborah M, Autor ; Pei Chuen Lee, Autor ; Fonseca Flores, Marisol, Autor ; Pilar Orive, Francisco Javier, Autor ; Pei Wen, Jane Ng, Autor ; González Dambrauskas, Sebastián, Autor ; Lee, Jan Hau, Autor . - 2025. Obra : JAMA Network Open Idioma : Inglés (eng) Resumen : Importance: The use of hypertonic saline (HTS) vs mannitol in the control of elevated intracranial pressure (ICP) secondary to neurotrauma is debated. Objective: To compare mortality and functional outcomes of treatment with 3% HTS vs 20% mannitol among children with moderate to severe traumatic brain injury (TBI) at risk of elevated ICP. Design, setting, and participants: This prospective, multicenter cohort study was conducted between June 1, 2018, and December 31, 2022, at 28 participating pediatric intensive care units in the Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) and the Red Colaborativa Pediátrica de Latinoamérica (LARed) in Asia, Latin America, and Europe. The study included children (aged Mención de responsabilidad : Shu-Ling Chong, MD, MPH; Yanan Zhu, PhD; Quan Wang, MD; Paula Caporal, MPH; Juan D. Roa, MD; Freddy Israel Pantoja Chamorro, MD;Thelma Elvira Teran Miranda, MD; Hongxing Dang, MD; Chin Seng Gan, MD; Qalab Abbas, MD; Ivan J. Ardila, MD; Mohannad Ahmad Antar, MD;Jesús A. Domínguez-Rojas, MD; María Miñambres Rodríguez, PhD; Natalia Zita Watzlawik, MD; Natalia Elizabeth Gómez Arriola, MD; Adriana Yock-Corrales, MD;Rubén Eduardo Lasso-Palomino, MD; Ming Mei Xiu, MD; Jacqueline S. M. Ong, MD; Hiroshi Kurosawa, MD; Gabriela Aparicio, MD; Chunfeng Liu, MD;Rujipat Samransamruajkit, MD; Juan C. Jaramillo-Bustamante, MD; Nattachai Anantasit, MD; Yek Kee Chor, MD; Deborah M. Turina, MD; Pei Chuen Lee, MD;Marisol Fonseca Flores, MD; Francisco Javier Pilar Orive, PhD; Jane Ng Pei Wen, BSc; Sebastián González-Dambrauskas, MD; Jan Hau Lee, MCI;for the Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) and the Red Colaborativa Pediátrica de Latinoamérica (LARed) Referencia : JAMA Netw Open . 2025 Mar 3;8(3):e250438. DOI (Digital Object Identifier) : 10.1001/jamanetworkopen.2025.0438. PMID : 40067302 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40067302/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Trajectory of unawareness of memory decline in individuals with autosomal dominant Alzheimer disease / Eliana Henao Arboleda    

Público ISBD Título : Trajectory of unawareness of memory decline in individuals with autosomal dominant Alzheimer disease Tipo de documento : documento electrónico Autores : Eliana Henao Arboleda, Fecha de publicación : 2020 Títulos uniformes : JAMA Network Open Idioma : Inglés (eng) Resumen : Importance: Recent studies have suggested that unawareness, or anosognosia, of memory decline is present in predementia stages of Alzheimer disease (AD) and may serve as an early symptomatic indicator of AD. Objective: To investigate the evolution of anosognosia of memory decline in individuals who carry the PSEN1 E280A variant for autosomal dominant AD compared with family members who do not carry the variant. Design, Setting, and Participants: This cohort study investigated a total of 2379 members of a Colombian kindred with autosomal dominant AD who were part of the Alzheimer’s Prevention Initiative Registry. Assessments were completed at the University of Antioquia, Colombia, with data collected between January 1, 2000, and July 31, 2019. Main Outcomes and Measures: Awareness of memory function was operationalized using the discrepancy between self-report and study partner report on a memory complaint scale. Linear mixed effects models were used to assess memory self-awareness over age separately in variant carriers and noncarriers. Results: This study included 396 variant carriers (mean [SD] age, 32.7 [11.9] years; 200 [50.5%] female), of whom 59 (14.9%) were cognitively impaired, and 1983 cognitively unimpaired noncarriers (mean [SD] age, 33.5 [12.5] years; 1129 [56.9%] female). The variant carriers demonstrated increased awareness until the mean (SD) age of 35.0 (2.0) years and had anosognosia at approximately 43 years of age, approximately 6 years before their estimated median age of dementia onset (49 years; 95% CI, 49-51 years). Cognitively unimpaired noncarriers reported more complaints than their study partners aged 20 and 60 years (10.1 points, P  Mención de responsabilidad : Patrizia Vannini, PhD; Bernard J. Hanseeuw, MD, PhD; Jennifer R. Gatchel, MD, PhD; Sietske A. M. Sikkes, PhD; Diana Alzate, BA; Yesica Zuluaga, MA; Sonia Moreno, PhD; Luis Mendez, MA; Ana Baena, MA; Paula Ospina-Lopera, BA; Victoria Tirado, MA; Eliana Henao, MA; Natalia Acosta-Baena, MD, MSc; Margarita Giraldo, MD; Francisco Lopera, MD; Yakeel T. Quiroz, PhD Referencia : JAMA Netw Open. 2020 Dec 1;3(12):e2027472. DOI (Digital Object Identifier) : 10.1001/jamanetworkopen.2020.27472 PMID : 33263761 Derechos de uso : CC BY En línea : https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2773465 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Trajectory of unawareness of memory decline in individuals with autosomal dominant Alzheimer disease [documento electrónico] / Eliana Henao Arboleda,  . - 2020. Obra : JAMA Network Open Idioma : Inglés (eng) Resumen : Importance: Recent studies have suggested that unawareness, or anosognosia, of memory decline is present in predementia stages of Alzheimer disease (AD) and may serve as an early symptomatic indicator of AD. Objective: To investigate the evolution of anosognosia of memory decline in individuals who carry the PSEN1 E280A variant for autosomal dominant AD compared with family members who do not carry the variant. Design, Setting, and Participants: This cohort study investigated a total of 2379 members of a Colombian kindred with autosomal dominant AD who were part of the Alzheimer’s Prevention Initiative Registry. Assessments were completed at the University of Antioquia, Colombia, with data collected between January 1, 2000, and July 31, 2019. Main Outcomes and Measures: Awareness of memory function was operationalized using the discrepancy between self-report and study partner report on a memory complaint scale. Linear mixed effects models were used to assess memory self-awareness over age separately in variant carriers and noncarriers. Results: This study included 396 variant carriers (mean [SD] age, 32.7 [11.9] years; 200 [50.5%] female), of whom 59 (14.9%) were cognitively impaired, and 1983 cognitively unimpaired noncarriers (mean [SD] age, 33.5 [12.5] years; 1129 [56.9%] female). The variant carriers demonstrated increased awareness until the mean (SD) age of 35.0 (2.0) years and had anosognosia at approximately 43 years of age, approximately 6 years before their estimated median age of dementia onset (49 years; 95% CI, 49-51 years). Cognitively unimpaired noncarriers reported more complaints than their study partners aged 20 and 60 years (10.1 points, P  Mención de responsabilidad : Patrizia Vannini, PhD; Bernard J. Hanseeuw, MD, PhD; Jennifer R. Gatchel, MD, PhD; Sietske A. M. Sikkes, PhD; Diana Alzate, BA; Yesica Zuluaga, MA; Sonia Moreno, PhD; Luis Mendez, MA; Ana Baena, MA; Paula Ospina-Lopera, BA; Victoria Tirado, MA; Eliana Henao, MA; Natalia Acosta-Baena, MD, MSc; Margarita Giraldo, MD; Francisco Lopera, MD; Yakeel T. Quiroz, PhD Referencia : JAMA Netw Open. 2020 Dec 1;3(12):e2027472. DOI (Digital Object Identifier) : 10.1001/jamanetworkopen.2020.27472 PMID : 33263761 Derechos de uso : CC BY En línea : https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2773465 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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