BK virus nephropathy in a heart transplant recipient [documento electrónico] / John Fredy Nieto Ríos, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia,  . - 2020.
Obra : Brazilian Journal of Nephrology

Idioma : Inglés (eng)

Palabras clave :	Polyomavirus  BK virus  BK Virus Nephropathy  Organ Transplantation  Heart transplantation  Immunosuppression
Resumen :	BK virus nephropathy in kidney transplantation is widely recognized as an important cause of graft dysfunction and loss. In the case of transplants of organs other than kidney, BK virus nephropathy in native kidneys has been recognized as a cause of chronic kidney disease, which is related with immunosuppression; however, the diagnosis is usually late because the renal dysfunction is attributed to other causes, such as toxicity by anticalcineurinic drugs, interstitial nephritis due to medications, hemodynamic changes, diabetes, hypertension, etc. We report a case of BK virus nephropathy in a patient who underwent heart transplantation due to peripartum cardiomyopathy. The kidney biopsy reported active chronic tubulointerstitial nephritis associated with late stage polyomavirus nephritis and the blood viral load for BK virus was positive (logarithm 4.5). The immunosuppressive treatment was reduced, and after two years of follow-up, the patient had stable renal function with a serum creatinine of 2.5 mg/dL (GFR of 23.4 mL/min/1.73m2). We recommend that the BK virus be considered as a cause of renal dysfunction in heart transplant recipients, with the aim of detecting its replication in time to reduce immunosuppressive therapy before irreversible compromise of renal function may manifest.
Mención de responsabilidad :	John Fredy Nieto-Ríos, Diego Armando Benavides-Henao, Arbey Aristizabal-Alzate, Carol Morales-Contreras, Diana Carolina Chacón-Jaimes, Gustavo Zuluaga-Valencia, Lina María Serna-Higuita
Referencia :	J Bras Nefrol. Jul-Sep 2021;43(3):434-439.
DOI (Digital Object Identifier) :	10.1590/2175-8239-jbn-2020-0049
PMID :	33527977
Derechos de uso :	CC BY
En línea :	https://bjnephrology.org/en/article/bk-virus-nephropathy-in-a-heart-transplant-r [...]
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