International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria [documento electrónico] / Sergio Iván Hoyos Duque,  . - 2021.
Obra : JHEP Reports

Idioma : Inglés (eng)

Palabras clave :	Hepatocellular carcinoma  Downstaging  UCSF downstaging protocol  All-comers  Alpha-foetoprotein
Resumen :	Background & Aims: Good outcomes after liver transplantation (LT) have been reported after successfully downstaging to Milan criteria in more advanced hepatocellular carcinoma (HCC). We aimed to compare post-LT outcomes in patients receiving locoregional therapies (LRT) before LT according to Milan criteria and University of California San Francisco downstaging (UCSF-DS) protocol and ‘all-comers’. Methods: This multicentre cohort study included patients who received any LRT before LT from Europe and Latin America (2000–2018). We excluded patients with alpha-foetoprotein (AFP) above 1,000 ng/ml. Competing risk regression analysis for HCC recurrence was conducted, estimating subdistribution hazard ratios (SHRs) and corresponding 95% CIs. Results: From 2,441 LT patients, 70.1% received LRT before LT (n = 1,711). Of these, 80.6% were within Milan, 12.0% within UCSF-DS, and 7.4% all-comers. Successful downstaging was achieved in 45.2% (CI 34.8–55.8) and 38.2% (CI 25.4–52.3) of the UCSF-DS group and all-comers, respectively. The risk of recurrence was higher for all-comers (SHR 6.01 [p
Mención de responsabilidad :	Helena Degroote, Federico Piñero, Charlotte Costentin, Andrea Notarpaolo, Ilka F. Boin, Karim Boudjema, Cinzia Baccaro, Aline Lopes Chagas, Philippe Bachellier, Giuseppe Maria Ettorre, Jaime Poniachik, Fabrice Muscari, Fabrio Di Benedetto, Sergio Hoyos Duque, Ephrem Salame, Umberto Cillo, Adrián Gadano, Claire Vanlemmens, Stefano Fagiuoli, Fernando Rubinstein, Patrizia Burra, Daniel Cherqui, Marcelo Silva, Hans Van Vlierberghe, Christophe Duvoux, for the French-Italian-Belgium and Latin American collaborative group for HCC and liver transplantation
Referencia :	JHEP Rep. 2021 Jul 13;3(5):100331.
DOI (Digital Object Identifier) :	10.1016/j.jhepr.2021.100331
PMID :	34485882
Derechos de uso :	CC BY-NC-ND
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S2589555921001075
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5883