Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021.
Obra : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring

Idioma : Inglés (eng)

Palabras clave :	age-related  cortical thickness  familial Alzheimer's disease  lifespan  presenilin1  trajectory
Resumen :	Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset.
Mención de responsabilidad :	Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz
Referencia :	Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233.
DOI (Digital Object Identifier) :	10.1002/dad2.12233
PMID :	34541287
Derechos de uso :	CC BY-NC-ND
En línea :	https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5885