Gut microbiota alterations in critically ill older patients: a multicenter study [documento electrónico] / Adriana Giraldo Villa,  . - 2022.
Obra : BMC Geriatrics

Idioma : Inglés (eng)

Palabras clave :	Older adults  Critically ill  Gut microbiota  ICU  Sepsis  Dysbiosis
Resumen :	Background: Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods: This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results: In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p
Mención de responsabilidad :	Mesa Victoria, Valdés-Duque Beatriz Elena, Giraldo-Giraldo Nubia Amparo, Jailler-R Ana María, Giraldo-Villa Adriana, Acevedo-Castaño Irene, Yepes-M Mónica Alejandra, Barbosa-Barbosa Janeth & Agudelo-Ochoa Gloria María
Referencia :	BMC Geriatr. 2022 Apr 28;22(1):373.
DOI (Digital Object Identifier) :	10.1186/s12877-022-02981-0
PMID :	35484500
Derechos de uso :	CC BY
En línea :	https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-02981-0
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6025