| Título : |
Device-Associated Infections in COVID-19 Patients: Frequency of Resistant Bacteria, Predictors and Mortality in Medellín, Colombia |
| Tipo de documento : |
documento electrónico |
| Autores : |
Echeverri Toro, Lina Maria, Autor ; Ocampo, Diana Patricia, Autor ; Jiménez, Judy Natalia, Autor ; Salazar, Lorena, Autor ; Vargas, Carlos, Autor ; Gustavo Roncancio, Autor ; Roa, Maria Alejandra, Autor ; Vanegas, Johanna Marcela, Autor |
| Fecha de publicación : |
2024 |
| Títulos uniformes : |
Microorganisms
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
COVID-19; healthcare-associated infections; device-associated infections; bacterial resistance; carbapenemases |
| Resumen : |
Introduction: Increased antimicrobial use during the COVID-19 pandemic has raised concerns about the spread of resistant bacteria. This study analyzed the frequency of device-associated infections (DAI) caused by resistant bacteria, the predictors of these infections, and 30-day all-cause mortality in patients with and without COVID-19. Methods: A retrospective cohort study was conducted on DAI patients admitted to the ICU (intensive care unit) in 20 hospitals in Medellin, Colombia (2020–2021). The exposure assessed was the COVID-19 diagnosis, and outcomes analyzed were resistant bacterial infections and 30-day mortality. Clinical and microbiological information was collected from surveillance databases. Statistical analysis included generalized linear mixed-effects models. Results: Of the 1521 patients included, 1033 (67.9%) were COVID-19-positive and 1665 DAI were presented. Carbapenem-resistant Enterobacteriaceae (CRE) infections predominated during the study (n = 98; 9.9%). The patients with COVID-19 had a higher frequency of metallo-beta-lactamase-producing CRE infections (n = 15; 33.3%) compared to patients without the disease (n = 3; 13.0%). Long-stay in the ICU (RR: 2.09; 95% CI:?1.39–3.16), diabetes (RR: 1.73; 95% CI: 1.21–2.49), and mechanical ventilation (RR: 2.13; 95% CI: 1.01–4.51) were CRE infection predictors in COVID-19 patients, with a mortality rate of 60.3%. Conclusion: CRE infections were predominant in COVID-19 patients. In pandemic situations, the strategies to control DAI should be maintained to avoid infections caused by resistant bacteria, such as length of stay in the ICU and duration of mechanical ventilation. |
| Referencia : |
Ocampo, D.P.; Echeverri-Toro, L.M.; Jiménez, J.N.; Salazar, L.; Vargas, C.; Roncancio, G.; Roa, M.A. |
| DOI (Digital Object Identifier) : |
10.3390/microorganisms12040640 |
| Derechos de uso : |
CC BY |
| En línea : |
https://www.mdpi.com/2076-2607/12/4/640 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Device-Associated Infections in COVID-19 Patients: Frequency of Resistant Bacteria, Predictors and Mortality in Medellín, Colombia [documento electrónico] / Echeverri Toro, Lina Maria, Autor ; Ocampo, Diana Patricia, Autor ; Jiménez, Judy Natalia, Autor ; Salazar, Lorena, Autor ; Vargas, Carlos, Autor ; Gustavo Roncancio, Autor ; Roa, Maria Alejandra, Autor ; Vanegas, Johanna Marcela, Autor . - 2024. Obra : MicroorganismsIdioma : Inglés ( eng)
| Palabras clave : |
COVID-19; healthcare-associated infections; device-associated infections; bacterial resistance; carbapenemases |
| Resumen : |
Introduction: Increased antimicrobial use during the COVID-19 pandemic has raised concerns about the spread of resistant bacteria. This study analyzed the frequency of device-associated infections (DAI) caused by resistant bacteria, the predictors of these infections, and 30-day all-cause mortality in patients with and without COVID-19. Methods: A retrospective cohort study was conducted on DAI patients admitted to the ICU (intensive care unit) in 20 hospitals in Medellin, Colombia (2020–2021). The exposure assessed was the COVID-19 diagnosis, and outcomes analyzed were resistant bacterial infections and 30-day mortality. Clinical and microbiological information was collected from surveillance databases. Statistical analysis included generalized linear mixed-effects models. Results: Of the 1521 patients included, 1033 (67.9%) were COVID-19-positive and 1665 DAI were presented. Carbapenem-resistant Enterobacteriaceae (CRE) infections predominated during the study (n = 98; 9.9%). The patients with COVID-19 had a higher frequency of metallo-beta-lactamase-producing CRE infections (n = 15; 33.3%) compared to patients without the disease (n = 3; 13.0%). Long-stay in the ICU (RR: 2.09; 95% CI:?1.39–3.16), diabetes (RR: 1.73; 95% CI: 1.21–2.49), and mechanical ventilation (RR: 2.13; 95% CI: 1.01–4.51) were CRE infection predictors in COVID-19 patients, with a mortality rate of 60.3%. Conclusion: CRE infections were predominant in COVID-19 patients. In pandemic situations, the strategies to control DAI should be maintained to avoid infections caused by resistant bacteria, such as length of stay in the ICU and duration of mechanical ventilation. |
| Referencia : |
Ocampo, D.P.; Echeverri-Toro, L.M.; Jiménez, J.N.; Salazar, L.; Vargas, C.; Roncancio, G.; Roa, M.A. |
| DOI (Digital Object Identifier) : |
10.3390/microorganisms12040640 |
| Derechos de uso : |
CC BY |
| En línea : |
https://www.mdpi.com/2076-2607/12/4/640 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Device-Associated Infections in COVID-19 Patients: Frequency of Resistant Bacteria, Predictors and Mortality in Medellín, Colombia
