| Título : |
Factors associated with development of end stage renal disease during hospitalization in patients with microscopic polyangiitis and granulomatosis with polyangiitis in a population of northwestern Colombia |
| Otros títulos : |
Factores asociados con el desarrollo de falla renal crónica terminal durante la hospitalización en los pacientes con poliangitis microscópica y granulomatosis con poliangitis en una población del noroccidente colombiano |
| Tipo de documento : |
documento electrónico |
| Autores : |
Jhon Edwar García Rueda, Autor ; Cobaleda Cano, Santiago, Autor ; Andrés Felipe Echeverri García, Autor ; Trejos Tenorio, Adriana Margarita, Autor ; Javier Darío Márquez Hernández, Autor ; Luis Fernando Pinto Peñaranda, Autor |
| Fecha de publicación : |
2025 |
| Títulos uniformes : |
Revista Colombiana de Reumatología
|
| Idioma : |
Español (spa) |
| Palabras clave : |
ANCA; Microscopic polyangiitis; Polyangiitis with granulomatosis; Vasculitis |
| Resumen : |
Introduction: ANCA vasculitis has been associated with increased morbidity and mortality, high disease burden, and organ damage, especially renal. Objectives: To determine factors associated with end-stage kidney disease at hospital discharge in microscopic polyangiitis and granulomatosis with polyangiitis patients, to characterize our population, hospitalization causes, treatment received, and complications during stay. Materials and methods: Adults with previous or new diagnosis of microscopic polyangiitis and granulomatosis with polyangiitis who required hospitalization between January 01, 2013, and April 30, 2021, were included. Association with end-stage kidney disease development was evaluated by Pearson's Chi2 (?2) or Fisher's test, and Student's t or Mann-Whitney U test according to the nature of the variables. Exploratory multivariate models were made including factors associated with end-stage kidney disease. Results: Forty-three patients were included, microscopic polyangiitis 55.8, and granulomatosis with polyangiitis 44.25. Twelve patients (27.9%) developed early end-stage kidney disease. High blood pressure, high urea nitrogen levels on admission, as well as pulmonary oedema, and Five Factor Score > 1 entailed a higher risk. In contrast, normal kidney function on admission was a protective factor. Rapidly progressive glomerulonephritis and arterial hypertension on admission were associated with end-stage kidney disease. In adjusted exploratory models according to vasculitis type, Birmingham Vasculitis Activity Score, diffuse alveolar haemorrhage, and plasma exchange use were identified as factors to include in multivariate models in multicentre studies. Conclusion: 88% of patients had renal involvement and 27.9% developed end-stage kidney disease. Rapidly progressive glomerulonephritis and arterial hypertension on hospital admission were associated with early development of end-stage kidney disease while normal renal function on admission was a protective factor for this outcome. © 2024 Asociación Colombiana de Reumatología |
| Mención de responsabilidad : |
Cobaleda Cano, Santiago, Echeverri García, Andrés Felipe, Trejos Tenorio, Adriana Margarita, Márquez Hernández, Javier Darío, García Rueda, Jhon Edwar, Pinto Peñaranda, Luis Fernando |
| Referencia : |
Revista Colombiana de Reumatología Volume 32, Issue 1, January–March 2025, Pages 16-26 |
| DOI (Digital Object Identifier) : |
10.1016/j.rcreu.2023.11.004 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/abs/pii/S012181232300110X |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Factors associated with development of end stage renal disease during hospitalization in patients with microscopic polyangiitis and granulomatosis with polyangiitis in a population of northwestern Colombia = Factores asociados con el desarrollo de falla renal crónica terminal durante la hospitalización en los pacientes con poliangitis microscópica y granulomatosis con poliangitis en una población del noroccidente colombiano [documento electrónico] / Jhon Edwar García Rueda, Autor ; Cobaleda Cano, Santiago, Autor ; Andrés Felipe Echeverri García, Autor ; Trejos Tenorio, Adriana Margarita, Autor ; Javier Darío Márquez Hernández, Autor ; Luis Fernando Pinto Peñaranda, Autor . - 2025. Obra : Revista Colombiana de ReumatologíaIdioma : Español ( spa)
| Palabras clave : |
ANCA; Microscopic polyangiitis; Polyangiitis with granulomatosis; Vasculitis |
| Resumen : |
Introduction: ANCA vasculitis has been associated with increased morbidity and mortality, high disease burden, and organ damage, especially renal. Objectives: To determine factors associated with end-stage kidney disease at hospital discharge in microscopic polyangiitis and granulomatosis with polyangiitis patients, to characterize our population, hospitalization causes, treatment received, and complications during stay. Materials and methods: Adults with previous or new diagnosis of microscopic polyangiitis and granulomatosis with polyangiitis who required hospitalization between January 01, 2013, and April 30, 2021, were included. Association with end-stage kidney disease development was evaluated by Pearson's Chi2 (?2) or Fisher's test, and Student's t or Mann-Whitney U test according to the nature of the variables. Exploratory multivariate models were made including factors associated with end-stage kidney disease. Results: Forty-three patients were included, microscopic polyangiitis 55.8, and granulomatosis with polyangiitis 44.25. Twelve patients (27.9%) developed early end-stage kidney disease. High blood pressure, high urea nitrogen levels on admission, as well as pulmonary oedema, and Five Factor Score > 1 entailed a higher risk. In contrast, normal kidney function on admission was a protective factor. Rapidly progressive glomerulonephritis and arterial hypertension on admission were associated with end-stage kidney disease. In adjusted exploratory models according to vasculitis type, Birmingham Vasculitis Activity Score, diffuse alveolar haemorrhage, and plasma exchange use were identified as factors to include in multivariate models in multicentre studies. Conclusion: 88% of patients had renal involvement and 27.9% developed end-stage kidney disease. Rapidly progressive glomerulonephritis and arterial hypertension on hospital admission were associated with early development of end-stage kidney disease while normal renal function on admission was a protective factor for this outcome. © 2024 Asociación Colombiana de Reumatología |
| Mención de responsabilidad : |
Cobaleda Cano, Santiago, Echeverri García, Andrés Felipe, Trejos Tenorio, Adriana Margarita, Márquez Hernández, Javier Darío, García Rueda, Jhon Edwar, Pinto Peñaranda, Luis Fernando |
| Referencia : |
Revista Colombiana de Reumatología Volume 32, Issue 1, January–March 2025, Pages 16-26 |
| DOI (Digital Object Identifier) : |
10.1016/j.rcreu.2023.11.004 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/abs/pii/S012181232300110X |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Factors associated with development of end stage renal disease during hospitalization in patients with microscopic polyangiitis and granulomatosis with polyangiitis in a population of northwestern Colombia
