| Título : |
Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study |
| Tipo de documento: |
documento electrónico |
| Autores: |
Eliana López Barón, Autor |
| Fecha de publicación: |
2025 |
| Títulos uniformes: |
The Lancet Global Health
|
| Idioma : |
Inglés (eng) |
| Resumen: |
Background: Children in resource-constrained settings (RCS) have disproportionately high illness and mortality; however, the prevalence in RCS of paediatric acute critical illness (P-ACI; life-threatening conditions that require time-sensitive interventions) is unknown. Most P-ACI can be managed with basic critical care (stabilisation, fluid resuscitation, oxygen, and vital-organ support), but RCS hospitals often lack such essential services. This study estimated the prevalence and examined the aetiology of P-ACI among children at RCS hospitals to support critical care capacity building and inform resource allocation. Methods: We conducted a hybrid prospective cohort and multinational point prevalence study of acutely ill or injured children aged 28 days to 14 years who presented to RCS hospitals on four designated days between July 20, 2021, and July 12, 2022. We measured the proportion of participants with P-ACI, applying the definition for acute paediatric critical illness (DEFCRIT) framework for research in resource-variable settings, and followed up admitted patients for hospital outcomes. In participants with P-ACI, we report diagnoses associated with critical illness. We used descriptive statistics to summarise site and cohort data by country sociodemographic category (Socio-demographic Index; SDI) and multivariable logistic regression to assess whether country sociodemographic category was independently associated with P-ACI. Findings: The study included 46 sites, 19 countries, and 7538 children, among whom 2651 (35·2%) were admitted to hospital and 68 died (all-cause mortality 0·9% [95% CI 0·7–1·1]). 985 (13·1% [95% CI 12·3–13·9]) participants had P-ACI. Among all sociodemographic categories, P-ACI prevalence was highest (28·0% [26·0–30·1]; 512 of 1828 participants) in low-SDI countries (p |
| Mención de responsabilidad : |
Kortz, Teresa B, Holloway, Adrian, Agulnik, Asya, He, David, Rivera, Stephanie Gordon, Abbas, Qalab, Appiah, John Adabie, Arias, Anita V, Attebery, Jonah, Camacho-Cruz, Jhon, Caporal, Paula, de Sa Rodrigues, Karla Emilia, Fink, Ericka, Kissoon, Niranjan, Lee, Jan Hau, López-Barón, Eliana, Murthy, Srinivas, Muttalib, Fiona, Nielsen, Katie, Remy, Kenneth, Sakaan, Andre-von Arnim, Amelie von Saint, Rodrigues, Adriana Teixeira, Blackwelder, William, Wiens, Matthew, Bhutta, Adnan, Abdul-Mumin, Alhassan, Allen, Nabisere, Amarillo, Paloma,Amegan-Aho, Kokou H, Arancibia, Pamela C, Arif, Fehmina, Arteaga, Liliana Y, Asibey, Jacqueline G, Ávila Guerrero, Nataly, Bacha, Tigist, Beltran Hernandez, Briam D, Bwiza Muhire, Hippolyte, Calderon-Cardenas, Juan S, Cañete, Mariana Lucía, Chimedbazar, Dulamragchaa, Curi, Claudia P, Emmanuel, Tenywa, Escobar, Maria L, Esposto, Sofia, Figueroa Vargas, Arieth, Fustiñana, Ana L, Giulietti, Marina, Habib, Muhammad Irfan, Havugarurema, Pascal, Hernandez Somerson |
| Referencia : |
Lancet Glob Health . 2025 Feb;13(2):e212-e221. |
| DOI (Digital Object Identifier) : |
10.1016/S2214-109X(24)00450-9 |
| PMID : |
39890223 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea: |
https://pubmed.ncbi.nlm.nih.gov/39890223/ |
| Link: |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study [documento electrónico] / Eliana López Barón, Autor . - 2025. Oeuvre : The Lancet Global HealthIdioma : Inglés ( eng)
| Resumen: |
Background: Children in resource-constrained settings (RCS) have disproportionately high illness and mortality; however, the prevalence in RCS of paediatric acute critical illness (P-ACI; life-threatening conditions that require time-sensitive interventions) is unknown. Most P-ACI can be managed with basic critical care (stabilisation, fluid resuscitation, oxygen, and vital-organ support), but RCS hospitals often lack such essential services. This study estimated the prevalence and examined the aetiology of P-ACI among children at RCS hospitals to support critical care capacity building and inform resource allocation. Methods: We conducted a hybrid prospective cohort and multinational point prevalence study of acutely ill or injured children aged 28 days to 14 years who presented to RCS hospitals on four designated days between July 20, 2021, and July 12, 2022. We measured the proportion of participants with P-ACI, applying the definition for acute paediatric critical illness (DEFCRIT) framework for research in resource-variable settings, and followed up admitted patients for hospital outcomes. In participants with P-ACI, we report diagnoses associated with critical illness. We used descriptive statistics to summarise site and cohort data by country sociodemographic category (Socio-demographic Index; SDI) and multivariable logistic regression to assess whether country sociodemographic category was independently associated with P-ACI. Findings: The study included 46 sites, 19 countries, and 7538 children, among whom 2651 (35·2%) were admitted to hospital and 68 died (all-cause mortality 0·9% [95% CI 0·7–1·1]). 985 (13·1% [95% CI 12·3–13·9]) participants had P-ACI. Among all sociodemographic categories, P-ACI prevalence was highest (28·0% [26·0–30·1]; 512 of 1828 participants) in low-SDI countries (p |
| Mención de responsabilidad : |
Kortz, Teresa B, Holloway, Adrian, Agulnik, Asya, He, David, Rivera, Stephanie Gordon, Abbas, Qalab, Appiah, John Adabie, Arias, Anita V, Attebery, Jonah, Camacho-Cruz, Jhon, Caporal, Paula, de Sa Rodrigues, Karla Emilia, Fink, Ericka, Kissoon, Niranjan, Lee, Jan Hau, López-Barón, Eliana, Murthy, Srinivas, Muttalib, Fiona, Nielsen, Katie, Remy, Kenneth, Sakaan, Andre-von Arnim, Amelie von Saint, Rodrigues, Adriana Teixeira, Blackwelder, William, Wiens, Matthew, Bhutta, Adnan, Abdul-Mumin, Alhassan, Allen, Nabisere, Amarillo, Paloma,Amegan-Aho, Kokou H, Arancibia, Pamela C, Arif, Fehmina, Arteaga, Liliana Y, Asibey, Jacqueline G, Ávila Guerrero, Nataly, Bacha, Tigist, Beltran Hernandez, Briam D, Bwiza Muhire, Hippolyte, Calderon-Cardenas, Juan S, Cañete, Mariana Lucía, Chimedbazar, Dulamragchaa, Curi, Claudia P, Emmanuel, Tenywa, Escobar, Maria L, Esposto, Sofia, Figueroa Vargas, Arieth, Fustiñana, Ana L, Giulietti, Marina, Habib, Muhammad Irfan, Havugarurema, Pascal, Hernandez Somerson |
| Referencia : |
Lancet Glob Health . 2025 Feb;13(2):e212-e221. |
| DOI (Digital Object Identifier) : |
10.1016/S2214-109X(24)00450-9 |
| PMID : |
39890223 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea: |
https://pubmed.ncbi.nlm.nih.gov/39890223/ |
| Link: |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study
