| Título : |
O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA |
| Tipo de documento : |
documento electrónico |
| Autores : |
Juan Carlos Restrepo Gutiérrez, Autor |
| Fecha de publicación : |
2024 |
| Títulos uniformes : |
Annals of Hepatology
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Introduction and Methods Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America. Materials and Methods Multicenter prospective cohort study including patients with AH (2015-2022). We recorded clinical information, and the impact of infections was assessed using competing-risk models. Results We included 511 patients from 24 centers in 8 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru). The mean age was 50.1±11.9 years, 426 (83.9%) were men, 264 (58.2%) had a previous diagnosis of cirrhosis, and the median MELD at diagnosis was 24.6 [19.6–30.6] points. Out of the total, 25.9% died, and only 3.7% underwent liver transplantation during follow-up. Also, 44.5% of patients developed an infection. Of them, 50.9% presented with infection at admission, 30.8% developed an infection during hospitalization, and 18.3% presented an infection in both situations. The most common localizations at admission were pulmonary (32.4%), urinary tract (33.1%), spontaneous bacterial peritonitis (15.9%), and cutaneous (9.7%). The main localizations during hospitalization were pulmonary (34.4%), urinary tract (25.8%), spontaneous bacterial peritonitis (14.0%), and bacteremia (8.6%%). The incidence of multidrug-resistant (MDR) organisms was 11.2% at admission and 10.3% during hospitalization, while the incidence of extensively drug-resistant (XDR) organisms was 1.4% and 4.7%, respectively. The presence of infection was associated with higher mortality (sub-distribution hazard ratio [sHR] 1.92, 95%CI:1.56–2.37; p |
| Mención de responsabilidad : |
Luis Antonio Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, Katherine Maldonado, María Ayala, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes, Juan Pablo Roblero, Blanca Norero, Raul Lazarte, José Antonio Velarde, Janett Jacobo, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Jesús Varela, Scherezada Mejía, Rita Silva, Cristina Melo, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Couto,fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez,Melisa Dirchwolf, Pedro Montes, Patricia Guerra, Geraldine Ramos, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani Singal, Ramón Bataller, Vijay Shah, Patrick S. Kamath,Marco Arrese,Juan Pablo Arab |
| Referencia : |
Annals of Hepatology Volume 29, Supplement 1, February 2024, 101256 |
| DOI (Digital Object Identifier) : |
10.1016/j.aohep.2023.101256 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/pii/S1665268123003599 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor . - 2024. Obra : Annals of HepatologyIdioma : Inglés ( eng)
| Resumen : |
Introduction and Methods Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America. Materials and Methods Multicenter prospective cohort study including patients with AH (2015-2022). We recorded clinical information, and the impact of infections was assessed using competing-risk models. Results We included 511 patients from 24 centers in 8 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru). The mean age was 50.1±11.9 years, 426 (83.9%) were men, 264 (58.2%) had a previous diagnosis of cirrhosis, and the median MELD at diagnosis was 24.6 [19.6–30.6] points. Out of the total, 25.9% died, and only 3.7% underwent liver transplantation during follow-up. Also, 44.5% of patients developed an infection. Of them, 50.9% presented with infection at admission, 30.8% developed an infection during hospitalization, and 18.3% presented an infection in both situations. The most common localizations at admission were pulmonary (32.4%), urinary tract (33.1%), spontaneous bacterial peritonitis (15.9%), and cutaneous (9.7%). The main localizations during hospitalization were pulmonary (34.4%), urinary tract (25.8%), spontaneous bacterial peritonitis (14.0%), and bacteremia (8.6%%). The incidence of multidrug-resistant (MDR) organisms was 11.2% at admission and 10.3% during hospitalization, while the incidence of extensively drug-resistant (XDR) organisms was 1.4% and 4.7%, respectively. The presence of infection was associated with higher mortality (sub-distribution hazard ratio [sHR] 1.92, 95%CI:1.56–2.37; p |
| Mención de responsabilidad : |
Luis Antonio Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, Katherine Maldonado, María Ayala, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes, Juan Pablo Roblero, Blanca Norero, Raul Lazarte, José Antonio Velarde, Janett Jacobo, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Jesús Varela, Scherezada Mejía, Rita Silva, Cristina Melo, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Couto,fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez,Melisa Dirchwolf, Pedro Montes, Patricia Guerra, Geraldine Ramos, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani Singal, Ramón Bataller, Vijay Shah, Patrick S. Kamath,Marco Arrese,Juan Pablo Arab |
| Referencia : |
Annals of Hepatology Volume 29, Supplement 1, February 2024, 101256 |
| DOI (Digital Object Identifier) : |
10.1016/j.aohep.2023.101256 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/pii/S1665268123003599 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA
