| Título : |
POS1106 IMPACT OF LUPUS ACTIVITY AND DAMAGE ACCRUAL ON HOSPITAL-ACQUIRED BACTERIAL INFECTIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS |
| Tipo de documento : |
documento electrónico |
| Autores : |
Ruth María Eraso Garnica, Autor |
| Fecha de publicación : |
2024 |
| Títulos uniformes : |
Annals of the Rheumatic Diseases
|
| Idioma : |
Inglés (eng) |
| Nota de contenido : |
Background: Hospital-acquired bacterial infections significantly contribute to the mortality of patients with systemic lupus erythematosus (SLE). The connection between lupus activity, damage accrual, and the risk of nosocomial bacterial infections is not well-established and may be influenced by various confounding factors. Objectives: To assess the impact of disease activity and damage accrual as risk factors for nosocomial bacterial infections in SLE patients. Methods: A retrospective multicenter cohort study was conducted, involving 2217 SLE patients from ten institutions in Colombia. The relationship between lupus activity and organ damage with the occurrence of bacterial infection during hospitalization was evaluated. Lupus activity and damage were assessed using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) scores, respectively. Results were adjusted for confounding variables, including age, sex, chronic renal damage, and the use of glucocorticoids, immunosuppressants, and antimalarials in the preceding month. Logistic regression analyses were performed. Results: The median age was 33 years with an interquartile range (IQR) of 24-46. Eighty-seven percent were women, and 60% had lupus nephritis. The median lupus activity was 8 (IQR 2-13), and cumulative damage was 1 (IQR 0-2). The median length of stay and time to the event were 9 (IQR 6-15) and 8 days (IQR 5-14), respectively. There were 321 outcomes (14.5%). See Table 1. Both SLEDAI and SLICC scores were significantly associated with nosocomial bacterial infection, with unadjusted odds ratios (OR) of 1.05 (95% CI, 1.03-1.07) and 1.24 (95% CI, 1.16-1.32), respectively. OR adjusted for the confounding variables considered were 1.08 (95% CI, 1.06-1.10) for SLEDAI and 1.21 (95% CI, 1.12-1.32) for SLICC. See Table 2. Conclusion: After adjusting for relevant factors, lupus activity and cumulative organ damage were identified as clear risk factors for hospital-acquired bacterial infections in SLE patients. Each one-point increase in SLEDAI and SLICC scores was associated with an 8% and 21% increased risk, respectively. Additionally, our findings suggest a potential protective effect of antimalarials in this clinical context. |
| Mención de responsabilidad : |
M. Restrepo Escobar, A. L. Vanegas García, R. M. Eraso Garnica, L. Hernandez, C. Muñoz L. A. González, F. Jaimes, G. Vásquez |
| Referencia : |
Annals of the Rheumatic Diseases 2024;83:949-950. |
| DOI (Digital Object Identifier) : |
10.1136/annrheumdis-2024-eular.1039 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://ard.bmj.com/content/83/Suppl_1/949.2.info |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
POS1106 IMPACT OF LUPUS ACTIVITY AND DAMAGE ACCRUAL ON HOSPITAL-ACQUIRED BACTERIAL INFECTIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS [documento electrónico] / Ruth María Eraso Garnica, Autor . - 2024. Obra : Annals of the Rheumatic DiseasesIdioma : Inglés ( eng)
| Nota de contenido : |
Background: Hospital-acquired bacterial infections significantly contribute to the mortality of patients with systemic lupus erythematosus (SLE). The connection between lupus activity, damage accrual, and the risk of nosocomial bacterial infections is not well-established and may be influenced by various confounding factors. Objectives: To assess the impact of disease activity and damage accrual as risk factors for nosocomial bacterial infections in SLE patients. Methods: A retrospective multicenter cohort study was conducted, involving 2217 SLE patients from ten institutions in Colombia. The relationship between lupus activity and organ damage with the occurrence of bacterial infection during hospitalization was evaluated. Lupus activity and damage were assessed using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) scores, respectively. Results were adjusted for confounding variables, including age, sex, chronic renal damage, and the use of glucocorticoids, immunosuppressants, and antimalarials in the preceding month. Logistic regression analyses were performed. Results: The median age was 33 years with an interquartile range (IQR) of 24-46. Eighty-seven percent were women, and 60% had lupus nephritis. The median lupus activity was 8 (IQR 2-13), and cumulative damage was 1 (IQR 0-2). The median length of stay and time to the event were 9 (IQR 6-15) and 8 days (IQR 5-14), respectively. There were 321 outcomes (14.5%). See Table 1. Both SLEDAI and SLICC scores were significantly associated with nosocomial bacterial infection, with unadjusted odds ratios (OR) of 1.05 (95% CI, 1.03-1.07) and 1.24 (95% CI, 1.16-1.32), respectively. OR adjusted for the confounding variables considered were 1.08 (95% CI, 1.06-1.10) for SLEDAI and 1.21 (95% CI, 1.12-1.32) for SLICC. See Table 2. Conclusion: After adjusting for relevant factors, lupus activity and cumulative organ damage were identified as clear risk factors for hospital-acquired bacterial infections in SLE patients. Each one-point increase in SLEDAI and SLICC scores was associated with an 8% and 21% increased risk, respectively. Additionally, our findings suggest a potential protective effect of antimalarials in this clinical context. |
| Mención de responsabilidad : |
M. Restrepo Escobar, A. L. Vanegas García, R. M. Eraso Garnica, L. Hernandez, C. Muñoz L. A. González, F. Jaimes, G. Vásquez |
| Referencia : |
Annals of the Rheumatic Diseases 2024;83:949-950. |
| DOI (Digital Object Identifier) : |
10.1136/annrheumdis-2024-eular.1039 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://ard.bmj.com/content/83/Suppl_1/949.2.info |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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POS1106 IMPACT OF LUPUS ACTIVITY AND DAMAGE ACCRUAL ON HOSPITAL-ACQUIRED BACTERIAL INFECTIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
