| Título : |
Experience in the diagnosis and treatment of AL amyloidosis in a high-complexity center in Medellín, Colombia |
| Tipo de documento : |
documento electrónico |
| Autores : |
Kenny Mauricio Gálvez Cárdenas, Autor ; Morantes Rubiano, Juan Felipe, Autor ; Cardenas, Valentina, Autor |
| Fecha de publicación : |
2025 |
| Títulos uniformes : |
blood glo
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
In patients with multiple myeloma it is necessary to have high clinical suspicion to rule out the presence of AL amyloidosis. |
| Resumen : |
This study describes the demographic, clinical, paraclinical, imaging, therapeutic, and prognostic characteristics in patients with immunoglobulin light chain (AL) amyloidosis in a high-complexity institution. A retrospective cohort of patients diagnosed with AL amyloidosis was assessed at the Pablo Tobón Uribe Hospital in Medellín, Colombia, from January 2010 to May 2023. A total of 33 patients were included, of whom 20 (60.6%) were women, and the median age was 62 (range, 48-77) years. According to the revised Mayo Clinic staging system, disease stratification was 29.6%, 44.4%, 11.1%, and 7% for stages I, II, III, and IV, respectively. Multiple myeloma and Waldenström’s macroglobulinemia were present in 22 (66%) and 1 (3%) patient, respectively. The median overall survival was 66 months (interquartile range [IQR], 30-119), which decreased to 35 months (IQR, 10-63) with cardiac involvement and to 33 months (IQR, 11-55) with concurrent multiple myeloma. In contrast, patients who underwent hematopoietic transplantation had a longer survival of 136 months (IQR, 33-136). The 5-year overall survival was 44.9% (95% confidence interval, 26.8-63). Our findings are consistent with the existing literature, with some distinctions such as a female predominance and high frequency of concurrent multiple myeloma. Cardiac involvement, multiple myeloma, and renal involvement were associated with reduced overall survival, suggesting their role as adverse prognostic factors. |
| Mención de responsabilidad : |
Kenny Galvez, Juan Felipe Morantes Rubiano, Valentina Cardenas |
| DOI (Digital Object Identifier) : |
10.1016/j.bglo.2025.100015 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/pii/S3050565825000150 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Experience in the diagnosis and treatment of AL amyloidosis in a high-complexity center in Medellín, Colombia [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, Autor ; Morantes Rubiano, Juan Felipe, Autor ; Cardenas, Valentina, Autor . - 2025. Obra : blood gloIdioma : Inglés ( eng)
| Palabras clave : |
In patients with multiple myeloma it is necessary to have high clinical suspicion to rule out the presence of AL amyloidosis. |
| Resumen : |
This study describes the demographic, clinical, paraclinical, imaging, therapeutic, and prognostic characteristics in patients with immunoglobulin light chain (AL) amyloidosis in a high-complexity institution. A retrospective cohort of patients diagnosed with AL amyloidosis was assessed at the Pablo Tobón Uribe Hospital in Medellín, Colombia, from January 2010 to May 2023. A total of 33 patients were included, of whom 20 (60.6%) were women, and the median age was 62 (range, 48-77) years. According to the revised Mayo Clinic staging system, disease stratification was 29.6%, 44.4%, 11.1%, and 7% for stages I, II, III, and IV, respectively. Multiple myeloma and Waldenström’s macroglobulinemia were present in 22 (66%) and 1 (3%) patient, respectively. The median overall survival was 66 months (interquartile range [IQR], 30-119), which decreased to 35 months (IQR, 10-63) with cardiac involvement and to 33 months (IQR, 11-55) with concurrent multiple myeloma. In contrast, patients who underwent hematopoietic transplantation had a longer survival of 136 months (IQR, 33-136). The 5-year overall survival was 44.9% (95% confidence interval, 26.8-63). Our findings are consistent with the existing literature, with some distinctions such as a female predominance and high frequency of concurrent multiple myeloma. Cardiac involvement, multiple myeloma, and renal involvement were associated with reduced overall survival, suggesting their role as adverse prognostic factors. |
| Mención de responsabilidad : |
Kenny Galvez, Juan Felipe Morantes Rubiano, Valentina Cardenas |
| DOI (Digital Object Identifier) : |
10.1016/j.bglo.2025.100015 |
| Derechos de uso : |
CC BY-NC-ND |
| En línea : |
https://www.sciencedirect.com/science/article/pii/S3050565825000150 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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