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Autor Juan Carlos Restrepo Gutiérrez
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Médico Internista Hepatólogo, Hospital Pablo Tobón Uribe
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Título : Hacia una nueva comprensión de la ferroptosis Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor Fecha de publicación : 2025 Títulos uniformes : Hepatología Idioma : Español (spa) Idioma original : Español (spa) Palabras clave : ferroptosis peróxidos lipídicos metabolismo del hierro. Resumen : La ferroptosis es un tipo de muerte celular regulada, recientemente descrita, caracterizada por la acumulación de peróxidos lipídicos dependientes de hierro, que lleva al daño celular irreversible. A diferencia de la apoptosis u otras formas de necrosis, la ferroptosis es impulsada por el desbalance en el metabolismo del hierro y del glutatión, el principal antioxidante celular. Esta vía ha captado creciente interés en la investigación biomédica debido a su implicación en diversas enfermedades, incluidas aquellas que afectan al hígado.
Mención de responsabilidad : Juan Carlos Restrepo Gutiérrez Referencia : Hepatología, 6(1), 11–12 DOI (Digital Object Identifier) : 10.59093/27112330.130 Derechos de uso : CC BY-NC-ND En línea : https://revistahepatologia.org/index.php/hepa/article/view/130 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Hacia una nueva comprensión de la ferroptosis [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor . - 2025.
Obra : Hepatología
Idioma : Español (spa) Idioma original : Español (spa)
Palabras clave : ferroptosis peróxidos lipídicos metabolismo del hierro. Resumen : La ferroptosis es un tipo de muerte celular regulada, recientemente descrita, caracterizada por la acumulación de peróxidos lipídicos dependientes de hierro, que lleva al daño celular irreversible. A diferencia de la apoptosis u otras formas de necrosis, la ferroptosis es impulsada por el desbalance en el metabolismo del hierro y del glutatión, el principal antioxidante celular. Esta vía ha captado creciente interés en la investigación biomédica debido a su implicación en diversas enfermedades, incluidas aquellas que afectan al hígado.
Mención de responsabilidad : Juan Carlos Restrepo Gutiérrez Referencia : Hepatología, 6(1), 11–12 DOI (Digital Object Identifier) : 10.59093/27112330.130 Derechos de uso : CC BY-NC-ND En línea : https://revistahepatologia.org/index.php/hepa/article/view/130 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002368 AC-2025-051 Archivo digital Producción Científica Artículos científicos Disponible Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation / Juan Carlos Restrepo Gutiérrez ; Codes, Liana ; Zapata, Rodrigo ; Mendizabal, Manuel ; Fleck Junior, Alfeu de Medeiros ; de Lucca Schiavon, Leonardo ; Sá Malbouisson, Luiz Marcelo ; Andraus, Wellington ; Gadano, Adrian ; Padilla Machaca, P Martin ; Bello Stucchi, Raquel Silveira ; Castro Narro, Graciela Elia ; Pages, Josefina ; Benedita Terrabuio, Debora Raquel ; Urzúa, Álvaro ; Guimarães Pesso, Mário ; Mainardi, Victoria ; Rodolpho, Pedro ; Imventarza, Oscar ; Gerona, Solange ; Wolff, Rodrigo ; Abdala, Edson ; Tenorio, Laura ; Cerda Reyes, Eira ; Cairo, Fernando ; Uribe, Mario ; Lisboa Bittencourt, Paulo
Título : Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor ; Codes, Liana, Autor ; Zapata, Rodrigo, Autor ; Mendizabal, Manuel, Autor ; Fleck Junior, Alfeu de Medeiros, Autor ; de Lucca Schiavon, Leonardo, Autor ; Sá Malbouisson, Luiz Marcelo, Autor ; Andraus, Wellington, Autor ; Gadano, Adrian, Autor ; Padilla Machaca, P Martin, Autor ; Bello Stucchi, Raquel Silveira, Autor ; Castro Narro, Graciela Elia, Autor ; Pages, Josefina, Autor ; Benedita Terrabuio, Debora Raquel, Autor ; Urzúa, Álvaro, Autor ; Guimarães Pesso, Mário, Autor ; Mainardi, Victoria, Autor ; Rodolpho, Pedro, Autor ; Imventarza, Oscar, Autor ; Gerona, Solange, Autor ; Wolff, Rodrigo, Autor ; Abdala, Edson, Autor ; Tenorio, Laura, Autor ; Cerda Reyes, Eira, Autor ; Cairo, Fernando, Autor ; Uribe, Mario, Autor ; Lisboa Bittencourt, Paulo, Autor Fecha de publicación : 2025 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Immunosuppression; Latin America; Liver transplantation; Postoperative care Resumen : Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America. © 2025 Fundación Clínica Médica Sur, A.C. Mención de responsabilidad : Codes, Liana; Zapata, Rodrigo; Mendizabal, Manuel; Junior, Alfeu de Medeiros Fleck; Restrepo, Juan Carlos; Schiavon, Leonardo de Lucca; Malbouisson, Luiz Marcelo Sá; Andraus, Wellington; Gadano, Adrian; Padilla-Machaca, P. Martin; Villamil, Alejandra; Stucchi, Raquel Silveira Bello; Castro-Narro, Graciela Elia; Pages, Josefina; Terrabuio, Debora Raquel Benedita; Urzúa, Alvaro; Pessoa, Mário Guimarães; Mainardi, Victoria; Pedro, Rodolpho; Imventarza, Oscar; Gerona, Solange; Wolff, Rodrigo; Abdala, Edson; Tenorio, Laura; Cerda-Reyes, Eira; Cairo, Fernando; Uribe, Mario; Bittencourt, Paulo Lisboa; Chong, Ricardo; Figueroa, Norma Marlene Perez; González, John Byron Abad; Murillo, Pablo Coste. Referencia : Ann Hepatol . 2025 Mar 7;30(2):101899. doi: 10.1016/j.aohep.2025.101899. DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101899 PMID : 40057036 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057036/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor ; Codes, Liana, Autor ; Zapata, Rodrigo, Autor ; Mendizabal, Manuel, Autor ; Fleck Junior, Alfeu de Medeiros, Autor ; de Lucca Schiavon, Leonardo, Autor ; Sá Malbouisson, Luiz Marcelo, Autor ; Andraus, Wellington, Autor ; Gadano, Adrian, Autor ; Padilla Machaca, P Martin, Autor ; Bello Stucchi, Raquel Silveira, Autor ; Castro Narro, Graciela Elia, Autor ; Pages, Josefina, Autor ; Benedita Terrabuio, Debora Raquel, Autor ; Urzúa, Álvaro, Autor ; Guimarães Pesso, Mário, Autor ; Mainardi, Victoria, Autor ; Rodolpho, Pedro, Autor ; Imventarza, Oscar, Autor ; Gerona, Solange, Autor ; Wolff, Rodrigo, Autor ; Abdala, Edson, Autor ; Tenorio, Laura, Autor ; Cerda Reyes, Eira, Autor ; Cairo, Fernando, Autor ; Uribe, Mario, Autor ; Lisboa Bittencourt, Paulo, Autor . - 2025.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Palabras clave : Immunosuppression; Latin America; Liver transplantation; Postoperative care Resumen : Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America. © 2025 Fundación Clínica Médica Sur, A.C. Mención de responsabilidad : Codes, Liana; Zapata, Rodrigo; Mendizabal, Manuel; Junior, Alfeu de Medeiros Fleck; Restrepo, Juan Carlos; Schiavon, Leonardo de Lucca; Malbouisson, Luiz Marcelo Sá; Andraus, Wellington; Gadano, Adrian; Padilla-Machaca, P. Martin; Villamil, Alejandra; Stucchi, Raquel Silveira Bello; Castro-Narro, Graciela Elia; Pages, Josefina; Terrabuio, Debora Raquel Benedita; Urzúa, Alvaro; Pessoa, Mário Guimarães; Mainardi, Victoria; Pedro, Rodolpho; Imventarza, Oscar; Gerona, Solange; Wolff, Rodrigo; Abdala, Edson; Tenorio, Laura; Cerda-Reyes, Eira; Cairo, Fernando; Uribe, Mario; Bittencourt, Paulo Lisboa; Chong, Ricardo; Figueroa, Norma Marlene Perez; González, John Byron Abad; Murillo, Pablo Coste. Referencia : Ann Hepatol . 2025 Mar 7;30(2):101899. doi: 10.1016/j.aohep.2025.101899. DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101899 PMID : 40057036 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057036/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Moderate alcohol-associated hepatitis: A real-world multicenter study Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor ; Díaz, Luis Antonio, Autor ; Dunn, Winston, Autor ; Mehta, Heer, Autor ; Muñoz, Karen, Autor ; Caldentey, Vicente, Autor ; Arnold, Jorge, Autor ; Ayares, Gustavo, Autor ; Mortuza, Rokhsana, Autor ; Sarin, Shiv K., Autor ; Maiwall, Rakhi, Autor ; Zhang, Wei, Autor ; Qian, Steve, Autor ; Simonetto, Douglas, Autor ; Singal, Ashwani K., Autor ; Elfeki, Mohamed A., Autor ; Ramirez Cadiz, Carolina, Autor ; Malhi, Gurpreet, Autor ; Ahmed, Adan, Autor ; Homsi, Hoomam, Autor ; Abid, Zinia, Autor ; Cabezas, Joaquín, Autor ; Echavarría, Victor, Autor ; Poca, Maria, Autor ; Soriano, German, Autor ; Cuyas, Berta, Autor ; Ventura Cots, Meritxell, Autor ; Higuera De La Tijera, María Fátima, Autor ; Ayala Valverde, Maria, Autor ; Pérez, Diego, Autor ; Gomez, Jaime, Autor ; Al-Karaghouli, Mustafa, Autor ; Jalal, Prasun K., Autor ; Ibrahim, Mohamad Ali, Autor ; García Tsao, Guadalupe, Autor ; Goyes, Daniela, Autor ; Skladaný, Lubomir, Autor ; Havaj, Daniel J., Autor ; Adamcova Selcanova, Svetlana, Autor ; Rincón, Diego, Autor ; Chacko, Kristina R., Autor ; Yaquich, Pamela, Autor ; Toro, Luis G., Autor ; Shah, Vijay, Autor ; Arrese, Marco, Autor ; Kamath, Patrick S., Autor ; Bataller, Ramon, Autor ; Arab, Juan Pablo, Autor Fecha de publicación : 2025 Títulos uniformes : Hepatology Communications Idioma : Inglés (eng) Resumen : Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a "less severe condition" (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009-2019) included patients with mAH (MELD score ?20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ?20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15-19), Maddrey discriminant function (mDF) of 33 (22-40), the trajectory of serum bilirubin of 0.83 (0.60-1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96-8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27-1.76, p Mención de responsabilidad : Idalsoaga, Francisco1,2; Díaz, Luis Antonio1,3; Dunn, Winston4; Mehta, Heer4; Muñoz, Karen5; Caldentey, Vicente5; Arnold, Jorge1; Ayares, Gustavo2; Mortuza, Rokhsana2; Sarin, Shiv K.6; Maiwall, Rakhi6; Zhang, Wei7; Qian, Steve8; Simonetto, Douglas9; Singal, Ashwani K.10; Elfeki, Mohamed A.10; Ramirez-Cadiz, Carolina11; Malhi, Gurpreet2; Ahmed, Adan2; Homsi, Hoomam2; Abid, Zinia2; Cabezas, Joaquín12,13; Echavarría, Victor12,13; Poca, Maria14; Soriano, German14; Cuyas, Berta14; Ventura Cots, Meritxell15; Higuera-De La Tijera, María Fátima16; Ayala-Valverde, Maria17; Perez, Diego17; Gomez, Jaime17; Abraldes, Juan G18; Al-Karaghouli, Mustafa18; Jalal, Prasun K.19; Ibrahim, Mohamad Ali19; García-Tsao, Guadalupe20; Goyes, Daniela20; Skladaný, Lubomir21; Havaj, Daniel J.21; Sulejova, Karolina21; Adamcova Selcanova, Svetlana21; Rincón, Diego22,23; Chacko, Kristina R.24; Restrepo, Juan C.25; Yaquich, Pamela26; Toro, Luis G.27; Shah, Vijay9; Arrese, Marco1; Kamath, Patrick S.9; Bataller, Ramon28 Referencia : Hepatology Communications 9(4):e0673, April 2025. DOI (Digital Object Identifier) : 10.1097/HC9.0000000000000673 Derechos de uso : CC BY En línea : https://journals.lww.com/hepcomm/fulltext/2025/04010/moderate_alcohol_associated [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Moderate alcohol-associated hepatitis: A real-world multicenter study [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor ; Díaz, Luis Antonio, Autor ; Dunn, Winston, Autor ; Mehta, Heer, Autor ; Muñoz, Karen, Autor ; Caldentey, Vicente, Autor ; Arnold, Jorge, Autor ; Ayares, Gustavo, Autor ; Mortuza, Rokhsana, Autor ; Sarin, Shiv K., Autor ; Maiwall, Rakhi, Autor ; Zhang, Wei, Autor ; Qian, Steve, Autor ; Simonetto, Douglas, Autor ; Singal, Ashwani K., Autor ; Elfeki, Mohamed A., Autor ; Ramirez Cadiz, Carolina, Autor ; Malhi, Gurpreet, Autor ; Ahmed, Adan, Autor ; Homsi, Hoomam, Autor ; Abid, Zinia, Autor ; Cabezas, Joaquín, Autor ; Echavarría, Victor, Autor ; Poca, Maria, Autor ; Soriano, German, Autor ; Cuyas, Berta, Autor ; Ventura Cots, Meritxell, Autor ; Higuera De La Tijera, María Fátima, Autor ; Ayala Valverde, Maria, Autor ; Pérez, Diego, Autor ; Gomez, Jaime, Autor ; Al-Karaghouli, Mustafa, Autor ; Jalal, Prasun K., Autor ; Ibrahim, Mohamad Ali, Autor ; García Tsao, Guadalupe, Autor ; Goyes, Daniela, Autor ; Skladaný, Lubomir, Autor ; Havaj, Daniel J., Autor ; Adamcova Selcanova, Svetlana, Autor ; Rincón, Diego, Autor ; Chacko, Kristina R., Autor ; Yaquich, Pamela, Autor ; Toro, Luis G., Autor ; Shah, Vijay, Autor ; Arrese, Marco, Autor ; Kamath, Patrick S., Autor ; Bataller, Ramon, Autor ; Arab, Juan Pablo, Autor . - 2025.
Obra : Hepatology Communications
Idioma : Inglés (eng)
Resumen : Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a "less severe condition" (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009-2019) included patients with mAH (MELD score ?20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ?20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15-19), Maddrey discriminant function (mDF) of 33 (22-40), the trajectory of serum bilirubin of 0.83 (0.60-1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96-8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27-1.76, p Mención de responsabilidad : Idalsoaga, Francisco1,2; Díaz, Luis Antonio1,3; Dunn, Winston4; Mehta, Heer4; Muñoz, Karen5; Caldentey, Vicente5; Arnold, Jorge1; Ayares, Gustavo2; Mortuza, Rokhsana2; Sarin, Shiv K.6; Maiwall, Rakhi6; Zhang, Wei7; Qian, Steve8; Simonetto, Douglas9; Singal, Ashwani K.10; Elfeki, Mohamed A.10; Ramirez-Cadiz, Carolina11; Malhi, Gurpreet2; Ahmed, Adan2; Homsi, Hoomam2; Abid, Zinia2; Cabezas, Joaquín12,13; Echavarría, Victor12,13; Poca, Maria14; Soriano, German14; Cuyas, Berta14; Ventura Cots, Meritxell15; Higuera-De La Tijera, María Fátima16; Ayala-Valverde, Maria17; Perez, Diego17; Gomez, Jaime17; Abraldes, Juan G18; Al-Karaghouli, Mustafa18; Jalal, Prasun K.19; Ibrahim, Mohamad Ali19; García-Tsao, Guadalupe20; Goyes, Daniela20; Skladaný, Lubomir21; Havaj, Daniel J.21; Sulejova, Karolina21; Adamcova Selcanova, Svetlana21; Rincón, Diego22,23; Chacko, Kristina R.24; Restrepo, Juan C.25; Yaquich, Pamela26; Toro, Luis G.27; Shah, Vijay9; Arrese, Marco1; Kamath, Patrick S.9; Bataller, Ramon28 Referencia : Hepatology Communications 9(4):e0673, April 2025. DOI (Digital Object Identifier) : 10.1097/HC9.0000000000000673 Derechos de uso : CC BY En línea : https://journals.lww.com/hepcomm/fulltext/2025/04010/moderate_alcohol_associated [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor Fecha de publicación : 2024 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Resumen : Introduction and Methods Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America. Materials and Methods Multicenter prospective cohort study including patients with AH (2015-2022). We recorded clinical information, and the impact of infections was assessed using competing-risk models. Results We included 511 patients from 24 centers in 8 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru). The mean age was 50.1±11.9 years, 426 (83.9%) were men, 264 (58.2%) had a previous diagnosis of cirrhosis, and the median MELD at diagnosis was 24.6 [19.6–30.6] points. Out of the total, 25.9% died, and only 3.7% underwent liver transplantation during follow-up. Also, 44.5% of patients developed an infection. Of them, 50.9% presented with infection at admission, 30.8% developed an infection during hospitalization, and 18.3% presented an infection in both situations. The most common localizations at admission were pulmonary (32.4%), urinary tract (33.1%), spontaneous bacterial peritonitis (15.9%), and cutaneous (9.7%). The main localizations during hospitalization were pulmonary (34.4%), urinary tract (25.8%), spontaneous bacterial peritonitis (14.0%), and bacteremia (8.6%%). The incidence of multidrug-resistant (MDR) organisms was 11.2% at admission and 10.3% during hospitalization, while the incidence of extensively drug-resistant (XDR) organisms was 1.4% and 4.7%, respectively. The presence of infection was associated with higher mortality (sub-distribution hazard ratio [sHR] 1.92, 95%CI:1.56–2.37; p Mención de responsabilidad : Luis Antonio Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, Katherine Maldonado, María Ayala, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes, Juan Pablo Roblero, Blanca Norero, Raul Lazarte, José Antonio Velarde, Janett Jacobo, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Jesús Varela, Scherezada Mejía, Rita Silva, Cristina Melo, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Couto,fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez,Melisa Dirchwolf, Pedro Montes, Patricia Guerra, Geraldine Ramos, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani Singal, Ramón Bataller, Vijay Shah, Patrick S. Kamath,Marco Arrese,Juan Pablo Arab Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101256 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101256 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003599 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor . - 2024.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Resumen : Introduction and Methods Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America. Materials and Methods Multicenter prospective cohort study including patients with AH (2015-2022). We recorded clinical information, and the impact of infections was assessed using competing-risk models. Results We included 511 patients from 24 centers in 8 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru). The mean age was 50.1±11.9 years, 426 (83.9%) were men, 264 (58.2%) had a previous diagnosis of cirrhosis, and the median MELD at diagnosis was 24.6 [19.6–30.6] points. Out of the total, 25.9% died, and only 3.7% underwent liver transplantation during follow-up. Also, 44.5% of patients developed an infection. Of them, 50.9% presented with infection at admission, 30.8% developed an infection during hospitalization, and 18.3% presented an infection in both situations. The most common localizations at admission were pulmonary (32.4%), urinary tract (33.1%), spontaneous bacterial peritonitis (15.9%), and cutaneous (9.7%). The main localizations during hospitalization were pulmonary (34.4%), urinary tract (25.8%), spontaneous bacterial peritonitis (14.0%), and bacteremia (8.6%%). The incidence of multidrug-resistant (MDR) organisms was 11.2% at admission and 10.3% during hospitalization, while the incidence of extensively drug-resistant (XDR) organisms was 1.4% and 4.7%, respectively. The presence of infection was associated with higher mortality (sub-distribution hazard ratio [sHR] 1.92, 95%CI:1.56–2.37; p Mención de responsabilidad : Luis Antonio Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, Katherine Maldonado, María Ayala, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes, Juan Pablo Roblero, Blanca Norero, Raul Lazarte, José Antonio Velarde, Janett Jacobo, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Jesús Varela, Scherezada Mejía, Rita Silva, Cristina Melo, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Couto,fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez,Melisa Dirchwolf, Pedro Montes, Patricia Guerra, Geraldine Ramos, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani Singal, Ramón Bataller, Vijay Shah, Patrick S. Kamath,Marco Arrese,Juan Pablo Arab Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101256 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101256 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003599 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : O-7 CURRENT PRACTICE OF LIVER TRANSPLANTATION IN LATIN AMERICAN COUNTRIES: AN ALEH INTEREST GROUP SURVEY 2023 Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor Fecha de publicación : 2024 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Resumen : Introduction and Objectives Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis of cytomegalovirus (CMV) infection and hepatitis B virus (HBV) recurrence in different active LATAM centers. Materials and Methods A web-based survey with 20 questions regarding LT practice was sent to all members of ALEH LT SIG in December 2022. Results 22 centers performing 35 [5-160] LT per year from Brazil (n=5), Argentina (n=4), Chile (n=4), Ecuador (n-2), Mexico (n=2), Colombia (n=1), Costa Rica (n=1), Peru (n=1), Dominican Republic (n=1) and Uruguay (n=1) answered the survey. Tacrolimus, mycophenolate and prednisone was the main immunosuppressive regimen employed by most (72%) centers and 81% of them referred basiliximab use for induction therapy in selected patients. Tailoring of immunosuppression was universally accepted, particularly in autoimmune hepatitis (AIH) (59%), hepatocellular carcinoma (54%) kidney dysfunction (77%) and primary biliary cirrhosis (33%). Weaning of corticosteroids at three, six and 12 months after LT was reported, respectively, by 41%, 36% and 23% of the centers, but policy for lifelong corticosteroid use in AIH-transplanted subjects was commonly observed (90%). Just four centers are currently performing protocol liver biopsies, while 18 of them are considering liver biopsy prior to steroid pulse therapy. HBIG and nucleos(t)ide analogs are used in most instances (73%) for HBV recurrence prevention, whereas CMV infection prophylaxis was shown to vary sharply across centers. Of note, all but two of them referred major changes in LT practice over the years due to economical restraints. Conclusions Compliance with standard of care recommendations for management of LT was reported by most centers. Heterogeneity in practices regarding HBV infection recurrence and CMV prophylaxis may reflect local financial restraints and point to the importance of developing ALEH guidelines to encourage LT activity in LATAM. Mención de responsabilidad : Paulo Bittencourt, Liana Codes, Adrian Gadano, Alejandra Villamil, Alfeu de Medeiros Fleck Jr, Álvaro Urzua, Debora Raquel Terrabuio, Eira Cerda, Graciela Elia Castro Narro, Ignacio Roca, John Abad González, Josefina Pages, Juan Carlos Restrepo Gutierrez, Leonardo de Lucca Schiavon, Mario Uribe, Martin Padilla, Norma Marlene Perez Figueroa, Pablo Coste Murillo, Raquel Stucchi, Ricardo Chong, Rodrigo Wolff, Victoria Mainardi, Rodrigo Zapata. Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101257 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101257 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003605 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis O-7 CURRENT PRACTICE OF LIVER TRANSPLANTATION IN LATIN AMERICAN COUNTRIES: AN ALEH INTEREST GROUP SURVEY 2023 [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor . - 2024.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Resumen : Introduction and Objectives Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis of cytomegalovirus (CMV) infection and hepatitis B virus (HBV) recurrence in different active LATAM centers. Materials and Methods A web-based survey with 20 questions regarding LT practice was sent to all members of ALEH LT SIG in December 2022. Results 22 centers performing 35 [5-160] LT per year from Brazil (n=5), Argentina (n=4), Chile (n=4), Ecuador (n-2), Mexico (n=2), Colombia (n=1), Costa Rica (n=1), Peru (n=1), Dominican Republic (n=1) and Uruguay (n=1) answered the survey. Tacrolimus, mycophenolate and prednisone was the main immunosuppressive regimen employed by most (72%) centers and 81% of them referred basiliximab use for induction therapy in selected patients. Tailoring of immunosuppression was universally accepted, particularly in autoimmune hepatitis (AIH) (59%), hepatocellular carcinoma (54%) kidney dysfunction (77%) and primary biliary cirrhosis (33%). Weaning of corticosteroids at three, six and 12 months after LT was reported, respectively, by 41%, 36% and 23% of the centers, but policy for lifelong corticosteroid use in AIH-transplanted subjects was commonly observed (90%). Just four centers are currently performing protocol liver biopsies, while 18 of them are considering liver biopsy prior to steroid pulse therapy. HBIG and nucleos(t)ide analogs are used in most instances (73%) for HBV recurrence prevention, whereas CMV infection prophylaxis was shown to vary sharply across centers. Of note, all but two of them referred major changes in LT practice over the years due to economical restraints. Conclusions Compliance with standard of care recommendations for management of LT was reported by most centers. Heterogeneity in practices regarding HBV infection recurrence and CMV prophylaxis may reflect local financial restraints and point to the importance of developing ALEH guidelines to encourage LT activity in LATAM. Mención de responsabilidad : Paulo Bittencourt, Liana Codes, Adrian Gadano, Alejandra Villamil, Alfeu de Medeiros Fleck Jr, Álvaro Urzua, Debora Raquel Terrabuio, Eira Cerda, Graciela Elia Castro Narro, Ignacio Roca, John Abad González, Josefina Pages, Juan Carlos Restrepo Gutierrez, Leonardo de Lucca Schiavon, Mario Uribe, Martin Padilla, Norma Marlene Perez Figueroa, Pablo Coste Murillo, Raquel Stucchi, Ricardo Chong, Rodrigo Wolff, Victoria Mainardi, Rodrigo Zapata. Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101257 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101257 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003605 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002185 AC-2024-038 Archivo digital Producción Científica Artículos científicos Disponible La piel como reflejo de trastornos hepáticos subyacentes / Juan Carlos Restrepo Gutiérrez en Hepatología, Vol. 5 No. 1 (2024)
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