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Autor Lina Maria Serna Higuita
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Médica Pediatra Nefróloga, Hospital Pablo Tobón Uribe
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Immunosupressive therapy in children with steroid-resistant nephrotic syndrome: single center experience / Catalina Vélez Echeverri ; Gustavo Adolfo Zuluaga Valencia ; Lina Maria Serna Higuita ; John Jairo Zuleta Tobón ; Juan José Vanegas Ruiz
Título : Immunosupressive therapy in children with steroid-resistant nephrotic syndrome: single center experience Tipo de documento : documento electrónico Autores : Catalina Vélez Echeverri, ; Gustavo Adolfo Zuluaga Valencia, ; Lina Maria Serna Higuita, ; John Jairo Zuleta Tobón, ; Juan José Vanegas Ruiz, Fecha de publicación : 2013 Títulos uniformes : Brazilian Journal of Nephrology Idioma : Inglés (eng) Palabras clave : Immunosuppressive Agents Chronic Kidney Failure mycophenolic acid Nephrotic Syndrome Resumen : INTRODUCTION: Nephrotic syndrome is one of the most frequent glomerular diseases among children, and steroid therapy remains as the treatment choice. In spite of this, 10 to 15% of the patients are steroidresistant, and the best therapy for such cases has never been defined. Mycophenolate acid (MA) is one of the treatments used in such situations. OBJECTIVE: To describe the clinical behavior of children diagnosed with steroid-resistant nephrotic syndrome (SRNS) and to assess the therapeutic response to MA. METHODS: This was a retrospective and descriptive study. RESULTS: 26 clinical records of patients with SRNS; 70% male and 30% female. All patients underwent kidney biopsies, which showed a predominance of focal segmental glomerulosclerosis (FSGS). The immunosuppresive drugs used were: Mycophenolate mofetil (MMF) 100%, Cyclosporine 69.2%, Cyclophosphamide 23.1%, and Rituximab 23%. One month after treatment initiation with MMF 61.5% achieved remission. The median of relapses per year for the patients was 3 (p25: 2.75 – p75: 4). This median became 1 (p25: 1 – p75: 3.25) after using this medication (p = 0.08). Furthermore, prior to the start of the MMF treatment, the median of the steroid dose was 1 (p25: 0.5- p75: 1.62) mg/k/day. After using MMF, this median became 0.07 (p25: 0 – p75: 0.55) mg/k/day (p Mención de responsabilidad : Catalina Velez Echeverri, Gustavo Adolfo Zuluaga Valencia, Lina Maria Serna Higuita, Ana Katherina Serrano Gayubo, Carolina Lucia Ochoa, Luisa Fernanda Rojas Rosas, Laura Carolina Muñoz, Javier Sierra, Jhon Jairo Zuleta, Juan José Vanegas Ruiz Referencia : J Bras Nefrol. Jul-Sep 2013;35(3):200-5. DOI (Digital Object Identifier) : 10.5935/0101-2800.20130032 PMID : 24100739 Derechos de uso : CC BY En línea : https://bjnephrology.org/en/article/immunosupressive-therapy-in-children-with-st [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4951 Immunosupressive therapy in children with steroid-resistant nephrotic syndrome: single center experience [documento electrónico] / Catalina Vélez Echeverri, ; Gustavo Adolfo Zuluaga Valencia, ; Lina Maria Serna Higuita, ; John Jairo Zuleta Tobón, ; Juan José Vanegas Ruiz, . - 2013.
Obra : Brazilian Journal of Nephrology
Idioma : Inglés (eng)
Palabras clave : Immunosuppressive Agents Chronic Kidney Failure mycophenolic acid Nephrotic Syndrome Resumen : INTRODUCTION: Nephrotic syndrome is one of the most frequent glomerular diseases among children, and steroid therapy remains as the treatment choice. In spite of this, 10 to 15% of the patients are steroidresistant, and the best therapy for such cases has never been defined. Mycophenolate acid (MA) is one of the treatments used in such situations. OBJECTIVE: To describe the clinical behavior of children diagnosed with steroid-resistant nephrotic syndrome (SRNS) and to assess the therapeutic response to MA. METHODS: This was a retrospective and descriptive study. RESULTS: 26 clinical records of patients with SRNS; 70% male and 30% female. All patients underwent kidney biopsies, which showed a predominance of focal segmental glomerulosclerosis (FSGS). The immunosuppresive drugs used were: Mycophenolate mofetil (MMF) 100%, Cyclosporine 69.2%, Cyclophosphamide 23.1%, and Rituximab 23%. One month after treatment initiation with MMF 61.5% achieved remission. The median of relapses per year for the patients was 3 (p25: 2.75 – p75: 4). This median became 1 (p25: 1 – p75: 3.25) after using this medication (p = 0.08). Furthermore, prior to the start of the MMF treatment, the median of the steroid dose was 1 (p25: 0.5- p75: 1.62) mg/k/day. After using MMF, this median became 0.07 (p25: 0 – p75: 0.55) mg/k/day (p Mención de responsabilidad : Catalina Velez Echeverri, Gustavo Adolfo Zuluaga Valencia, Lina Maria Serna Higuita, Ana Katherina Serrano Gayubo, Carolina Lucia Ochoa, Luisa Fernanda Rojas Rosas, Laura Carolina Muñoz, Javier Sierra, Jhon Jairo Zuleta, Juan José Vanegas Ruiz Referencia : J Bras Nefrol. Jul-Sep 2013;35(3):200-5. DOI (Digital Object Identifier) : 10.5935/0101-2800.20130032 PMID : 24100739 Derechos de uso : CC BY En línea : https://bjnephrology.org/en/article/immunosupressive-therapy-in-children-with-st [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4951 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001537 AC-2013-161 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2013-161.pdfAdobe Acrobat PDF Middle aortic syndrome as the cause of renovascular hypertension in a 3-year-old girl: difficulties in the differential diagnosis / Catalina Vélez Echeverri ; Lina Maria Serna Higuita ; Juan José Vanegas Ruiz ; Margarita María Suárez Galvis ; José Miguel Hidalgo Oviedo ; Ruth María Eraso Garnica
Título : Middle aortic syndrome as the cause of renovascular hypertension in a 3-year-old girl: difficulties in the differential diagnosis Tipo de documento : documento electrónico Autores : Catalina Vélez Echeverri, ; Lina Maria Serna Higuita, ; Juan José Vanegas Ruiz, ; Margarita María Suárez Galvis, ; José Miguel Hidalgo Oviedo, ; Ruth María Eraso Garnica, Fecha de publicación : 2013 Títulos uniformes : Nefrología Idioma : Inglés (eng) Mención de responsabilidad : Catalina Vélez-Echeverri, Margarita Suárez, Lina Serna-Higuita, Ana K Serrano-Gayubo, Juan J Vanegas-Ruiz, José M Hidalgo, Luis F Arias, Ruth M Eraso Referencia : Nefrologia. 2013;33(2):281-3. DOI (Digital Object Identifier) : 10.3265/Nefrologia.pre2012.Oct.11769 PMID : 23511769 Derechos de uso : CC BY-NC-ND En línea : https://www.revistanefrologia.com/es-linkresolver-sindrome-aorto-medial-como-cau [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3716 Middle aortic syndrome as the cause of renovascular hypertension in a 3-year-old girl: difficulties in the differential diagnosis [documento electrónico] / Catalina Vélez Echeverri, ; Lina Maria Serna Higuita, ; Juan José Vanegas Ruiz, ; Margarita María Suárez Galvis, ; José Miguel Hidalgo Oviedo, ; Ruth María Eraso Garnica, . - 2013.
Obra : Nefrología
Idioma : Inglés (eng)
Mención de responsabilidad : Catalina Vélez-Echeverri, Margarita Suárez, Lina Serna-Higuita, Ana K Serrano-Gayubo, Juan J Vanegas-Ruiz, José M Hidalgo, Luis F Arias, Ruth M Eraso Referencia : Nefrologia. 2013;33(2):281-3. DOI (Digital Object Identifier) : 10.3265/Nefrologia.pre2012.Oct.11769 PMID : 23511769 Derechos de uso : CC BY-NC-ND En línea : https://www.revistanefrologia.com/es-linkresolver-sindrome-aorto-medial-como-cau [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3716 Reserva
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2013-057.pdfAdobe Acrobat PDF Sickle cell crisis and acute humoural rejection in kidney graft / John Fredy Nieto Ríos ; Lina Maria Serna Higuita ; Gustavo Adolfo Zuluaga Valencia ; Arbey Aristizabal Álzate ; Catalina Ocampo Kohn
Título : Sickle cell crisis and acute humoural rejection in kidney graft Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Lina Maria Serna Higuita, ; Gustavo Adolfo Zuluaga Valencia, ; Arbey Aristizabal Álzate, ; Catalina Ocampo Kohn, Fecha de publicación : 2013 Títulos uniformes : Nefrología Idioma : Inglés (eng) Mención de responsabilidad : John F Nieto-Ríos, Lina M Serna-Higuita, Ana K Serrano-Gayubo, Arbey Aristizabal-Alzate, Catalina Ocampo-Kohn, Rafael Andrade-Pérez, Gustavo Zuluaga-Valencia Referencia : Nefrologia. 2013;33(2):286-8. DOI (Digital Object Identifier) : 10.3265/Nefrologia.pre2012.Oct.11760 PMID : 23511772 Derechos de uso : CC BY-NC-ND En línea : https://www.revistanefrologia.com/es-linkresolver-crisis-falciforme-rechazo-agud [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3717 Sickle cell crisis and acute humoural rejection in kidney graft [documento electrónico] / John Fredy Nieto Ríos, ; Lina Maria Serna Higuita, ; Gustavo Adolfo Zuluaga Valencia, ; Arbey Aristizabal Álzate, ; Catalina Ocampo Kohn, . - 2013.
Obra : Nefrología
Idioma : Inglés (eng)
Mención de responsabilidad : John F Nieto-Ríos, Lina M Serna-Higuita, Ana K Serrano-Gayubo, Arbey Aristizabal-Alzate, Catalina Ocampo-Kohn, Rafael Andrade-Pérez, Gustavo Zuluaga-Valencia Referencia : Nefrologia. 2013;33(2):286-8. DOI (Digital Object Identifier) : 10.3265/Nefrologia.pre2012.Oct.11760 PMID : 23511772 Derechos de uso : CC BY-NC-ND En línea : https://www.revistanefrologia.com/es-linkresolver-crisis-falciforme-rechazo-agud [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3717 Reserva
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2013-058.pdfAdobe Acrobat PDF Survival of renal transplantation patients older than 60 years: a single-center experience / John Fredy Nieto Ríos ; Lina Maria Serna Higuita
Título : Survival of renal transplantation patients older than 60 years: a single-center experience Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Lina Maria Serna Higuita, Fecha de publicación : 2013 Títulos uniformes : Transplantation Proceedings Idioma : Inglés (eng) Resumen : Background: Elderly patients are the fastest growing population requiring renal replacement therapy. It has been stated that renal transplantation may be the best treatment option for these patients. However, it has been observed that older patients have a higher mortality rate than those who are younger. Yet the factors that determine post-transplantation outcomes in this population remain poorly defined. The aims of this study were to evaluate the graft and patient survival in kidney transplant recipients who are older than 60 years of age to identify relevant predictive factors. Methods: In this population-based retrospective cohort study of 201 kidney transplantations performed in elderly patients from January 2002 throughout June 2009, we estimated the 1-,3-,and 5-year patients and graft survival rates. We also evaluated the complications and the predictors of poor outcomes. Survival times were analyzed using the Kaplan–Meier method and survival differences assessed with Mantel-Cox log rank-test. We performed a Cox proportional hazards regression models to evaluate the impact of baseline and treatment characteristics on patient and graft survival. Results: Graft and patient survival rates at 1, 3, and 5 years were 76.4%, 71.3%, and 54.3%, and 78.2%, 73.8%, and 56.4%, respectively. Graft survival rates censored for patient death with a functioning graft were 93.1, 92.1, and 89%. Patient survival rates differed between diabetic and nondiabetic subjects at 1, 3 and 5 years (69.5% versus 83.6%; 59.8% versus 72.3%; 43.6% versus 65.7%; P = .008). On multivariate analysis, the factors associated with patients survival were diabetes mellitus (hazard ratio [HR] 2.058, 95% confidence interval [CI] 1.173–3.611, P = .012) and the 1-month serum creatinine value was > 1.6 mg/dL (HR 2.108 for each point increase, 95% CI 1.521–2.921, P = .000). Furthermore, there was an insignificant trend forward an association between active or past smoker and lower patient survival (HR 1.689, 95% CI 0.937–3.043, P = .08). The main causes of graft loss were patient death (79.5%). acute rejection (6.8%), and chronic allograft nephropathy (5.5%). Conclusion: Renal transplantation can be performed safely and with acceptable outcomes in elderly patients after appropriate clinical evaluation. The grafts show excellent survival albeit that deaths with a functional graft continue to be an important issue. Mención de responsabilidad : J R Rodelo, J F Nieto-Ríos, L M Serna-Higuita, J E Henao, A García, A C Reino, J C Tobón, M Arbeláez Referencia : Transplant Proc. 2013 May;45(4):1402-9. DOI (Digital Object Identifier) : 10.1016/j.transproceed.2012.10.053 PMID : 23726583 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(12)01403-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3719 Survival of renal transplantation patients older than 60 years: a single-center experience [documento electrónico] / John Fredy Nieto Ríos, ; Lina Maria Serna Higuita, . - 2013.
Obra : Transplantation Proceedings
Idioma : Inglés (eng)
Resumen : Background: Elderly patients are the fastest growing population requiring renal replacement therapy. It has been stated that renal transplantation may be the best treatment option for these patients. However, it has been observed that older patients have a higher mortality rate than those who are younger. Yet the factors that determine post-transplantation outcomes in this population remain poorly defined. The aims of this study were to evaluate the graft and patient survival in kidney transplant recipients who are older than 60 years of age to identify relevant predictive factors. Methods: In this population-based retrospective cohort study of 201 kidney transplantations performed in elderly patients from January 2002 throughout June 2009, we estimated the 1-,3-,and 5-year patients and graft survival rates. We also evaluated the complications and the predictors of poor outcomes. Survival times were analyzed using the Kaplan–Meier method and survival differences assessed with Mantel-Cox log rank-test. We performed a Cox proportional hazards regression models to evaluate the impact of baseline and treatment characteristics on patient and graft survival. Results: Graft and patient survival rates at 1, 3, and 5 years were 76.4%, 71.3%, and 54.3%, and 78.2%, 73.8%, and 56.4%, respectively. Graft survival rates censored for patient death with a functioning graft were 93.1, 92.1, and 89%. Patient survival rates differed between diabetic and nondiabetic subjects at 1, 3 and 5 years (69.5% versus 83.6%; 59.8% versus 72.3%; 43.6% versus 65.7%; P = .008). On multivariate analysis, the factors associated with patients survival were diabetes mellitus (hazard ratio [HR] 2.058, 95% confidence interval [CI] 1.173–3.611, P = .012) and the 1-month serum creatinine value was > 1.6 mg/dL (HR 2.108 for each point increase, 95% CI 1.521–2.921, P = .000). Furthermore, there was an insignificant trend forward an association between active or past smoker and lower patient survival (HR 1.689, 95% CI 0.937–3.043, P = .08). The main causes of graft loss were patient death (79.5%). acute rejection (6.8%), and chronic allograft nephropathy (5.5%). Conclusion: Renal transplantation can be performed safely and with acceptable outcomes in elderly patients after appropriate clinical evaluation. The grafts show excellent survival albeit that deaths with a functional graft continue to be an important issue. Mención de responsabilidad : J R Rodelo, J F Nieto-Ríos, L M Serna-Higuita, J E Henao, A García, A C Reino, J C Tobón, M Arbeláez Referencia : Transplant Proc. 2013 May;45(4):1402-9. DOI (Digital Object Identifier) : 10.1016/j.transproceed.2012.10.053 PMID : 23726583 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(12)01403-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3719 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000292 AC-2013-060 Archivo digital Producción Científica Artículos científicos Disponible Variante colapsante de la glomeruloesclerosis focal y segmentaria en niños / John Fredy Nieto Ríos ; Sandra Milena Brand ; Lina Maria Serna Higuita
Título : Variante colapsante de la glomeruloesclerosis focal y segmentaria en niños Otros títulos : Collapsing variant of focal segmental glomerulosclerosis in children Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Sandra Milena Brand, ; Lina Maria Serna Higuita, Fecha de publicación : 2013 Títulos uniformes : Iatreia Idioma : Español (spa) Palabras clave : Fallo Renal Crónico Glomeruloesclerosis Focal y Segmentaria Síndrome Nefrótico Resumen : La variedad colapsante de glomeruloesclerosis focal y segmentaria (GEFS) es una lesión renal que puede ser idiopática o estar asociada a diferentes factores; se caracteriza por colapso glomerular que lleva a un síndrome nefrótico corticorresistente y a falla renal crónica progresiva. Ha sido poco estudiada en niños y en ellos la mayoría de los casos son idiopáticos. Presentamos seis casos de esta variedad de GEFS en niños negativos para VIH, resistentes al tratamiento inmunosupresor; tres de ellos murieron. Mención de responsabilidad : John Fredy Nieto Ríos, Sandra Milena Brand, Lina María Serna Higuita, Luis Fernando Arias Referencia : Iatreia ; 26(4): 481-486, oct.-dic. 2013. Derechos de uso : CC BY-NC-ND En línea : https://revistas.udea.edu.co/index.php/iatreia/article/view/14323 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4526 Variante colapsante de la glomeruloesclerosis focal y segmentaria en niños = Collapsing variant of focal segmental glomerulosclerosis in children [documento electrónico] / John Fredy Nieto Ríos, ; Sandra Milena Brand, ; Lina Maria Serna Higuita, . - 2013.
Obra : Iatreia
Idioma : Español (spa)
Palabras clave : Fallo Renal Crónico Glomeruloesclerosis Focal y Segmentaria Síndrome Nefrótico Resumen : La variedad colapsante de glomeruloesclerosis focal y segmentaria (GEFS) es una lesión renal que puede ser idiopática o estar asociada a diferentes factores; se caracteriza por colapso glomerular que lleva a un síndrome nefrótico corticorresistente y a falla renal crónica progresiva. Ha sido poco estudiada en niños y en ellos la mayoría de los casos son idiopáticos. Presentamos seis casos de esta variedad de GEFS en niños negativos para VIH, resistentes al tratamiento inmunosupresor; tres de ellos murieron. Mención de responsabilidad : John Fredy Nieto Ríos, Sandra Milena Brand, Lina María Serna Higuita, Luis Fernando Arias Referencia : Iatreia ; 26(4): 481-486, oct.-dic. 2013. Derechos de uso : CC BY-NC-ND En línea : https://revistas.udea.edu.co/index.php/iatreia/article/view/14323 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4526 Reserva
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2013-112.pdfAdobe Acrobat PDF Histoplasmosis diseminada y síndrome hemofagocítico en dos pacientes trasplantados renales / John Fredy Nieto Ríos ; Arbey Aristizabal Álzate ; Catalina Ocampo Kohn ; Lina Maria Serna Higuita ; Gustavo Adolfo Zuluaga ValenciaPermalinkClinical description and evolution of renal transplant pediatric patients treated with alemtuzumab / Catalina Vélez Echeverri ; Gustavo Adolfo Zuluaga Valencia ; Catalina Ocampo Kohn ; Arbey Aristizabal Álzate ; Lina Maria Serna Higuita ; John Jairo Zuleta Tobón ; Juan José Vanegas RuizPermalink