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Autor Lady Diana Ladino Malagón
Comentario :
Médica Neuróloga, Hospital Pablo Tobón Uribe
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Documentos disponibles escritos por este autor (31)
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Diagnostic yield of the palmomental reflex in patients with suspected frontal lesion / Lady Diana Ladino Malagón
Título : Diagnostic yield of the palmomental reflex in patients with suspected frontal lesion Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2015 Títulos uniformes : Journal of the Neurological Sciences Idioma : Inglés (eng) Palabras clave : Diagnostic test. Marinesco–Radovici neurological signs physical examination primitive reflex semiology Resumen : Background: The purpose of this study was to determine the diagnostic value of the palmomental reflex in order to identify frontal lesions in neurological outpatients. Methods: Two hundred twenty-six neurological patients with suspected intracranial lesion with an indication for magnetic resonance imaging (MRI) were included. All patients underwent the same MRI protocol. The reflex was elicited by trained and standardized nurses, and was evaluated by two neurologists. The evaluation was blind and independent. The test's accuracy was calculated. The Kappa coefficient was used to calculate the interobserver and intra observer reliability. Results: The interobserver reliability between neurologists was 0.53 with 93% of agreement (p b 0.001). The diagnostic accuracy measures were as follow: sensitivity of 19%, specificity of 93%, positive predictive value of 30%, negative predictive value of 88%, positive likelihood ratio of 2.7 and negative likelihood ratio of 0.87. The area under the curve was 0.56. Conclusion: The palmomental reflex is associated with frontal structural lesions but the sensitivity is low, indicat ing a high percentage of frontal lesions with a negative reflex. When the test is used on its own, it is insufficient to detect frontal damage. Mención de responsabilidad : Lady D Ladino, Sandra Isaza, Jorge Delgado, Simon Rascovsky, Carlos Uribe, Santiago Acebedo, William Cornejo, Lizbeth Hernandez-Ronquillo, Jose F Tellez-Zenteno Referencia : J Neurol Sci. 2015 Dec 15;359(1-2):156-60. DOI (Digital Object Identifier) : 10.1016/j.jns.2015.11.003 PMID : 26671106 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(15)30011-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3915 Diagnostic yield of the palmomental reflex in patients with suspected frontal lesion [documento electrónico] / Lady Diana Ladino Malagón, . - 2015.
Obra : Journal of the Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : Diagnostic test. Marinesco–Radovici neurological signs physical examination primitive reflex semiology Resumen : Background: The purpose of this study was to determine the diagnostic value of the palmomental reflex in order to identify frontal lesions in neurological outpatients. Methods: Two hundred twenty-six neurological patients with suspected intracranial lesion with an indication for magnetic resonance imaging (MRI) were included. All patients underwent the same MRI protocol. The reflex was elicited by trained and standardized nurses, and was evaluated by two neurologists. The evaluation was blind and independent. The test's accuracy was calculated. The Kappa coefficient was used to calculate the interobserver and intra observer reliability. Results: The interobserver reliability between neurologists was 0.53 with 93% of agreement (p b 0.001). The diagnostic accuracy measures were as follow: sensitivity of 19%, specificity of 93%, positive predictive value of 30%, negative predictive value of 88%, positive likelihood ratio of 2.7 and negative likelihood ratio of 0.87. The area under the curve was 0.56. Conclusion: The palmomental reflex is associated with frontal structural lesions but the sensitivity is low, indicat ing a high percentage of frontal lesions with a negative reflex. When the test is used on its own, it is insufficient to detect frontal damage. Mención de responsabilidad : Lady D Ladino, Sandra Isaza, Jorge Delgado, Simon Rascovsky, Carlos Uribe, Santiago Acebedo, William Cornejo, Lizbeth Hernandez-Ronquillo, Jose F Tellez-Zenteno Referencia : J Neurol Sci. 2015 Dec 15;359(1-2):156-60. DOI (Digital Object Identifier) : 10.1016/j.jns.2015.11.003 PMID : 26671106 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(15)30011-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3915 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000496 AC-2015-049 Archivo digital Producción Científica Artículos científicos Disponible StatNet electroencephalogram: a fast and reliable option to diagnose nonconvulsive status epilepticus in emergency setting / Lady Diana Ladino Malagón
Título : StatNet electroencephalogram: a fast and reliable option to diagnose nonconvulsive status epilepticus in emergency setting Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2015 Títulos uniformes : Canadian Journal of Neurological Sciences Idioma : Inglés (eng) Palabras clave : disposable EEG electrodes emergency department emergent EEG intensive care unit nonconvulsive status epilepticus stat EEG Resumen : Background: The StatNet electrode set is a system that can be applied by a non-electroencephalogram (EEG) technologist after minimal training. The primary objectives of this study are to assess the quality and reliability of the StatNet recordings in comparison to the conventional EEG. Methods: Over 10 months, 19 patients with suspected nonconvulsive status epilepticus were included from university hospital emergency settings. Each patient received a StatNet EEG by a trained epilepsy fellow and a conventional EEG by registered technologists. We compared the studies in a blinded fashion, for the timeframe from EEG order to the setup time, start of acquisition, amount of artifact, and detection of abnormalities. The nonparametric Mann-Whitney two-sample t test was used for comparisons. The kappa score was used to assess reliability. Results: Mean age of patients was 61±16.3 (25-93) years. The inter-observer agreement for detection of abnormal findings was 0.83 for StatNet and 0.75 for conventional EEG. Nonconvulsive status epilepticus was detected in 10% (2/19) in both studies. The delay from the time of EEG requisition to acquisition was shorter in the StatNet (22.4±2.5 minutes) than the conventional EEG (217.7±44.6 minutes; p Mención de responsabilidad : Lady Diana Ladino, Alexandra Voll, Dianne Dash, Wes Sutherland, Lizbeth Hernández-Ronquillo, Jose Francisco Téllez-Zenteno, Farzad Moien-Afshari Referencia : Can J Neurol Sci. 2016 Mar;43(2):254-60. DOI (Digital Object Identifier) : 10.1017/cjn.2015.391 PMID : 26864547 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4580 StatNet electroencephalogram: a fast and reliable option to diagnose nonconvulsive status epilepticus in emergency setting [documento electrónico] / Lady Diana Ladino Malagón, . - 2015.
Obra : Canadian Journal of Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : disposable EEG electrodes emergency department emergent EEG intensive care unit nonconvulsive status epilepticus stat EEG Resumen : Background: The StatNet electrode set is a system that can be applied by a non-electroencephalogram (EEG) technologist after minimal training. The primary objectives of this study are to assess the quality and reliability of the StatNet recordings in comparison to the conventional EEG. Methods: Over 10 months, 19 patients with suspected nonconvulsive status epilepticus were included from university hospital emergency settings. Each patient received a StatNet EEG by a trained epilepsy fellow and a conventional EEG by registered technologists. We compared the studies in a blinded fashion, for the timeframe from EEG order to the setup time, start of acquisition, amount of artifact, and detection of abnormalities. The nonparametric Mann-Whitney two-sample t test was used for comparisons. The kappa score was used to assess reliability. Results: Mean age of patients was 61±16.3 (25-93) years. The inter-observer agreement for detection of abnormal findings was 0.83 for StatNet and 0.75 for conventional EEG. Nonconvulsive status epilepticus was detected in 10% (2/19) in both studies. The delay from the time of EEG requisition to acquisition was shorter in the StatNet (22.4±2.5 minutes) than the conventional EEG (217.7±44.6 minutes; p Mención de responsabilidad : Lady Diana Ladino, Alexandra Voll, Dianne Dash, Wes Sutherland, Lizbeth Hernández-Ronquillo, Jose Francisco Téllez-Zenteno, Farzad Moien-Afshari Referencia : Can J Neurol Sci. 2016 Mar;43(2):254-60. DOI (Digital Object Identifier) : 10.1017/cjn.2015.391 PMID : 26864547 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4580 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001078 AC-2015-084 Archivo digital Producción Científica Artículos científicos Disponible Management of antiepileptic drugs following epilepsy surgery: a meta-analysis / Lady Diana Ladino Malagón
Título : Management of antiepileptic drugs following epilepsy surgery: a meta-analysis Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Epilepsy Research Idioma : Inglés (eng) Palabras clave : Epilepsy surgery discontinuation drug-resistant AEDs seizure recurrence withdrawal Resumen : Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epilepsy Res. 2014;108(4):765-74. DOI (Digital Object Identifier) : 10.1016/j.eplepsyres.2014.01.024 PMID : 24613746 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 Management of antiepileptic drugs following epilepsy surgery: a meta-analysis [documento electrónico] / Lady Diana Ladino Malagón, . - 2014.
Obra : Epilepsy Research
Idioma : Inglés (eng)
Palabras clave : Epilepsy surgery discontinuation drug-resistant AEDs seizure recurrence withdrawal Resumen : Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epilepsy Res. 2014;108(4):765-74. DOI (Digital Object Identifier) : 10.1016/j.eplepsyres.2014.01.024 PMID : 24613746 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000367 AC-2014-033 Archivo digital Producción Científica Artículos científicos Disponible
Título : Medicinal marijuana for epilepsy: a case series study Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Canadian Journal of Neurological Sciences Dimensiones : Idioma : Inglés (eng) Palabras clave : anticonvulsant cannabis cannabinoids medicinal marijuana seizures Resumen : Objective: To describe the social, clinical and use-patterns characteristics of medicinal marijuana use among patients with epilepsy (PWEs). Methods: Eighteen PWEs with prescriptions for medicinal marijuana from a Canadian adult-epilepsy clinic were included in this study. Results: Eighteen patients had a prescription of medicinal marijuana from a total population of 800 PWEs in our center (2.2%). Mean age of patients was 30±7.4 (19-50) years. Twelve (67%) patients were males. Eleven (61%) patients had drug resistant epilepsy. Eleven (61%) patients suffered a psychiatric comorbidity and reported the use of illicit substances or heavy alcohol or tobacco consumption. Only two (11%) patients were married; the rest of patients (89%) were single or divorced. The drug use pattern was similar among patients. All patients asked for marijuana permission in the epilepsy clinic. Most (83%) had a previous history of marijuana smoking, with a mean of 6.6±3 (1-15) years. The mean consumption dose was 2.05±1.8 (0.5-8) grams per day. Ten (56%) patients reported withdrawal seizure exacerbation when they stopped the marijuana. Only two patients (11%) reported side effects, and all patients found medicinal marijuana very helpful for seizure control and improvement of mood disorder. Conclusions: PWEs using medicinal marijuana have a common profile. They are usually young single men with drug-resistant epilepsy and psychiatric comorbidity. Most used marijuana before formal prescription and all believe the drug was effective on their seizure control. Because of the concurrent use of other antiseizure medications, it is complex to estimate the actual effect of marijuana. Mención de responsabilidad : Lady Diana Ladino, Lizbeth Hernández-Ronquillo, José Francisco Téllez-Zenteno Referencia : Can J Neurol Sci. 2014 Nov;41(6):753-8 DOI (Digital Object Identifier) : 10.1017/cjn.2014.37 PMID : 25377755 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3416 Medicinal marijuana for epilepsy: a case series study [documento electrónico] / Lady Diana Ladino Malagón, . - 2014 . - ; PDF.
Obra : Canadian Journal of Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : anticonvulsant cannabis cannabinoids medicinal marijuana seizures Resumen : Objective: To describe the social, clinical and use-patterns characteristics of medicinal marijuana use among patients with epilepsy (PWEs). Methods: Eighteen PWEs with prescriptions for medicinal marijuana from a Canadian adult-epilepsy clinic were included in this study. Results: Eighteen patients had a prescription of medicinal marijuana from a total population of 800 PWEs in our center (2.2%). Mean age of patients was 30±7.4 (19-50) years. Twelve (67%) patients were males. Eleven (61%) patients had drug resistant epilepsy. Eleven (61%) patients suffered a psychiatric comorbidity and reported the use of illicit substances or heavy alcohol or tobacco consumption. Only two (11%) patients were married; the rest of patients (89%) were single or divorced. The drug use pattern was similar among patients. All patients asked for marijuana permission in the epilepsy clinic. Most (83%) had a previous history of marijuana smoking, with a mean of 6.6±3 (1-15) years. The mean consumption dose was 2.05±1.8 (0.5-8) grams per day. Ten (56%) patients reported withdrawal seizure exacerbation when they stopped the marijuana. Only two patients (11%) reported side effects, and all patients found medicinal marijuana very helpful for seizure control and improvement of mood disorder. Conclusions: PWEs using medicinal marijuana have a common profile. They are usually young single men with drug-resistant epilepsy and psychiatric comorbidity. Most used marijuana before formal prescription and all believe the drug was effective on their seizure control. Because of the concurrent use of other antiseizure medications, it is complex to estimate the actual effect of marijuana. Mención de responsabilidad : Lady Diana Ladino, Lizbeth Hernández-Ronquillo, José Francisco Téllez-Zenteno Referencia : Can J Neurol Sci. 2014 Nov;41(6):753-8 DOI (Digital Object Identifier) : 10.1017/cjn.2014.37 PMID : 25377755 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3416 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000419 AC-2014-085 Archivo digital Producción Científica Artículos científicos Disponible Obesity and its association with generalised epilepsy, idiopathic syndrome, and family history of epilepsy / Lady Diana Ladino Malagón
Título : Obesity and its association with generalised epilepsy, idiopathic syndrome, and family history of epilepsy Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Epileptic Disorders Idioma : Inglés (eng) Palabras clave : Body mass index genetic syndrome leisure activity overweight physical activity and waist circumference Resumen : Aim: Previous studies support the concept that obesity is a common comorbid condition in patients with epilepsy (PWE). In this study, we present the body mass index (BMI) and data from a survey to assess physical activity in a sample of PWE from an epilepsy clinic. Methods: Between June of 2011 and January of 2013, 100 PWE from an adult epilepsy clinic were included. We obtained BMI, waist circumference, and information regarding physical activity using a standardised questionnaire. Clinical, demographic, electrographic, and imaging parameters were collected from charts. Results: Mean age of patients was 40 ± 14 (18-77) years. The BMI distribution was as follows: 2 patients (2%) underweight, 26 (26%) normal weight, 34 (34%) overweight, 25 (25%) obese, and 13 (13%) with morbid obesity. In our study, obesity was defined as having a BMI ≥ 30. We found 38 (38%) patients in this range. There was no difference in the rate of drug-resistant epilepsy between obese and non-obese patients (55 vs. 55%; p=0.05). Leisure time habit was reported in 82% of obese patients and 79% of patients without obesity. Overall, the most frequent activity was walking (70%). Factors associated with obesity were generalised epilepsy (OR: 2.7, 1.1-6.6; p=0.012), idiopathic syndrome (OR: 2.7, 1.04-7; p=0.018), and family history of epilepsy (OR: 6.1, 1.5-24.2; p=0.002). Conclusion: Our study suggests an association between obesity, idiopathic generalised epilepsy, and family history of epilepsy. Our study shows that PWE are physically active and there is no clear relation between exercise and obesity. We could not identify any association between drug-resistant epilepsy and obesity. Absence of direct comparison with a control non-epileptic population; a cross-sectional design not allowing evaluation of a causal association among variables; and reliance on self-reported physical activity are to be considered as limitations of the present study. Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epileptic Disord. 2014 Sep;16(3):343-53. DOI (Digital Object Identifier) : 10.1684/epd.2014.0677 PMID : 25179745 En línea : https://www.jle.com/fr/revues/epd/e-docs/obesity_and_its_association_with_genera [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3767 Obesity and its association with generalised epilepsy, idiopathic syndrome, and family history of epilepsy [documento electrónico] / Lady Diana Ladino Malagón, . - 2014.
Obra : Epileptic Disorders
Idioma : Inglés (eng)
Palabras clave : Body mass index genetic syndrome leisure activity overweight physical activity and waist circumference Resumen : Aim: Previous studies support the concept that obesity is a common comorbid condition in patients with epilepsy (PWE). In this study, we present the body mass index (BMI) and data from a survey to assess physical activity in a sample of PWE from an epilepsy clinic. Methods: Between June of 2011 and January of 2013, 100 PWE from an adult epilepsy clinic were included. We obtained BMI, waist circumference, and information regarding physical activity using a standardised questionnaire. Clinical, demographic, electrographic, and imaging parameters were collected from charts. Results: Mean age of patients was 40 ± 14 (18-77) years. The BMI distribution was as follows: 2 patients (2%) underweight, 26 (26%) normal weight, 34 (34%) overweight, 25 (25%) obese, and 13 (13%) with morbid obesity. In our study, obesity was defined as having a BMI ≥ 30. We found 38 (38%) patients in this range. There was no difference in the rate of drug-resistant epilepsy between obese and non-obese patients (55 vs. 55%; p=0.05). Leisure time habit was reported in 82% of obese patients and 79% of patients without obesity. Overall, the most frequent activity was walking (70%). Factors associated with obesity were generalised epilepsy (OR: 2.7, 1.1-6.6; p=0.012), idiopathic syndrome (OR: 2.7, 1.04-7; p=0.018), and family history of epilepsy (OR: 6.1, 1.5-24.2; p=0.002). Conclusion: Our study suggests an association between obesity, idiopathic generalised epilepsy, and family history of epilepsy. Our study shows that PWE are physically active and there is no clear relation between exercise and obesity. We could not identify any association between drug-resistant epilepsy and obesity. Absence of direct comparison with a control non-epileptic population; a cross-sectional design not allowing evaluation of a causal association among variables; and reliance on self-reported physical activity are to be considered as limitations of the present study. Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epileptic Disord. 2014 Sep;16(3):343-53. DOI (Digital Object Identifier) : 10.1684/epd.2014.0677 PMID : 25179745 En línea : https://www.jle.com/fr/revues/epd/e-docs/obesity_and_its_association_with_genera [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3767 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000342 AC-2014-008 Archivo digital Producción Científica Artículos científicos Disponible A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy / Lady Diana Ladino MalagónPermalink