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Autor Fabián Alberto Jaimes Barragán
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Médico Epidemiólogo PHD, Hospital Pablo Tobón Uribe
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Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis / Mauricio Restrepo Escobar ; Paula Andrea Granda Carvajal ; Fabián Alberto Jaimes Barragán
Título : Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis Tipo de documento : documento electrónico Autores : Mauricio Restrepo Escobar, ; Paula Andrea Granda Carvajal, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2017 Títulos uniformes : Lupus Idioma : Inglés (eng) Palabras clave : Biopsy nephritis reliability renal lupus reproducibility of results systematic review Resumen : Objective: Before using a test, it should be determined whether the results are reliable. The reliability of the interpretation of renal biopsy in patients with lupus nephritis has not been clearly elucidated. Our objective was to estimate inter and intraobserver reliability of the histological classification, as well as activity and chronicity indices in renal biopsy of patients with lupus nephritis. Methods: We conducted a systematic search of the literature, which included articles in any language, using PubMed, Embase, Cochrane and Lilacs databases. Search terms included were: reproducibility, reliability, agreement, systemic lupus erythematosus and lupus nephritis. Comparative studies with any design were included, regardless of the year or the language of publication. Two investigators, independently, screened the literature published in accordance with pre-established inclusion and exclusion criteria. Results: We found 13 relevant studies. Inter-observer reproducibility of most measurements was moderate or low, despite the fact that, in most cases, the readings were made by expert nephropathologists. There was great diversity among designs, participants, including samples and outcomes evaluated in different studies. Although there are too many reports on the clinical use, studies evaluating the reliability of classifications on renal biopsy in lupus nephritis are rare. The quality of the methodological design and reporting was fair. Conclusion: The interpretation of renal biopsy in lupus nephritis is poorly reproducible, causing serious doubts about its validity and its clinical application. As it can lead to serious diagnosis, treatment and prognosis errors, it is necessary to intensify research in this field. Mención de responsabilidad : M Restrepo-Escobar, P A Granda-Carvajal, F Jaimes Referencia : Lupus. 2017 Dec;26(14):1502-1512. DOI (Digital Object Identifier) : 10.1177/0961203317706556 PMID : 28441914 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203317706556 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4048 Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis [documento electrónico] / Mauricio Restrepo Escobar, ; Paula Andrea Granda Carvajal, ; Fabián Alberto Jaimes Barragán, . - 2017.
Obra : Lupus
Idioma : Inglés (eng)
Palabras clave : Biopsy nephritis reliability renal lupus reproducibility of results systematic review Resumen : Objective: Before using a test, it should be determined whether the results are reliable. The reliability of the interpretation of renal biopsy in patients with lupus nephritis has not been clearly elucidated. Our objective was to estimate inter and intraobserver reliability of the histological classification, as well as activity and chronicity indices in renal biopsy of patients with lupus nephritis. Methods: We conducted a systematic search of the literature, which included articles in any language, using PubMed, Embase, Cochrane and Lilacs databases. Search terms included were: reproducibility, reliability, agreement, systemic lupus erythematosus and lupus nephritis. Comparative studies with any design were included, regardless of the year or the language of publication. Two investigators, independently, screened the literature published in accordance with pre-established inclusion and exclusion criteria. Results: We found 13 relevant studies. Inter-observer reproducibility of most measurements was moderate or low, despite the fact that, in most cases, the readings were made by expert nephropathologists. There was great diversity among designs, participants, including samples and outcomes evaluated in different studies. Although there are too many reports on the clinical use, studies evaluating the reliability of classifications on renal biopsy in lupus nephritis are rare. The quality of the methodological design and reporting was fair. Conclusion: The interpretation of renal biopsy in lupus nephritis is poorly reproducible, causing serious doubts about its validity and its clinical application. As it can lead to serious diagnosis, treatment and prognosis errors, it is necessary to intensify research in this field. Mención de responsabilidad : M Restrepo-Escobar, P A Granda-Carvajal, F Jaimes Referencia : Lupus. 2017 Dec;26(14):1502-1512. DOI (Digital Object Identifier) : 10.1177/0961203317706556 PMID : 28441914 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203317706556 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4048 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000648 AC-2017-037 Archivo digital Producción Científica Artículos científicos Disponible Validation of trauma scales: ISS, NISS, RTS and TRISS for predicting mortality in a Colombian population / Carlos Oliver Valderrama Molina ; Nelson Darío Giraldo Ramírez ; Alfredo Constain Franco ; Jaime Andrés Puerta Gómez ; Fabián Alberto Jaimes Barragán
Título : Validation of trauma scales: ISS, NISS, RTS and TRISS for predicting mortality in a Colombian population Tipo de documento : documento electrónico Autores : Carlos Oliver Valderrama Molina, ; Nelson Darío Giraldo Ramírez, ; Alfredo Constain Franco, ; Jaime Andrés Puerta Gómez, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2017 Títulos uniformes : European Journal of Orthopaedic Surgery & Traumatology Idioma : Inglés (eng) Palabras clave : Trauma Severity Indices multiple trauma mortality Resumen : Background: Our purpose was to validate the performance of the ISS, NISS, RTS and TRISS scales as predictors of mortality in a population of trauma patients in a Latin American setting. Materials and methods: Subjects older than 15 years with diagnosis of trauma, lesions in two or more body areas according to the AIS and whose initial attention was at the hospital in the first 24 h were included. The main outcome was inpatient mortality. Secondary outcomes were admission to the intensive care unit, requirement of mechanical ventilation and length of stay. A logistic regression model for hospital mortality was fitted with each of the scales as an independent variable, and its predictive accuracy was evaluated through discrimination and calibration statistics. Results: Between January 2007 and July 2015, 4085 subjects were enrolled in the study. 84.2% (n = 3442) were male, the mean age was 36 years (SD = 16), and the most common trauma mechanism was blunt type (80.1%; n = 3273). The medians of ISS, NISS, TRISS and RTS were: 14 (IQR = 10–21), 17 (IQR = 11–27), 4.21 (IQR = 2.95–5.05) and 7.84 (IQR = 6.90–7.84), respectively. Mortality was 9.3%, and the discrimination for ISS, NISS, TRISS and RTS was: AUC 0.85, 0.89, 0.86 and 0.92, respectively. No one scale had appropriate calibration. Conclusion: Determining the severity of trauma is an essential tool to guide treatment and establish the necessary resources for attention. In a Colombian population from a capital city, trauma scales have adequate performance for the prediction of mortality in patients with trauma. Mención de responsabilidad : Carlos Oliver Valderrama-Molina, Nelson Giraldo, Alfredo Constain, Andres Puerta, Camilo Restrepo, Alba León, Fabián Jaimes Referencia : Eur J Orthop Surg Traumatol. 2017 Feb;27(2):213-220. DOI (Digital Object Identifier) : 10.1007/s00590-016-1892-6 PMID : 27999959 En línea : https://link.springer.com/article/10.1007%2Fs00590-016-1892-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4042 Validation of trauma scales: ISS, NISS, RTS and TRISS for predicting mortality in a Colombian population [documento electrónico] / Carlos Oliver Valderrama Molina, ; Nelson Darío Giraldo Ramírez, ; Alfredo Constain Franco, ; Jaime Andrés Puerta Gómez, ; Fabián Alberto Jaimes Barragán, . - 2017.
Obra : European Journal of Orthopaedic Surgery & Traumatology
Idioma : Inglés (eng)
Palabras clave : Trauma Severity Indices multiple trauma mortality Resumen : Background: Our purpose was to validate the performance of the ISS, NISS, RTS and TRISS scales as predictors of mortality in a population of trauma patients in a Latin American setting. Materials and methods: Subjects older than 15 years with diagnosis of trauma, lesions in two or more body areas according to the AIS and whose initial attention was at the hospital in the first 24 h were included. The main outcome was inpatient mortality. Secondary outcomes were admission to the intensive care unit, requirement of mechanical ventilation and length of stay. A logistic regression model for hospital mortality was fitted with each of the scales as an independent variable, and its predictive accuracy was evaluated through discrimination and calibration statistics. Results: Between January 2007 and July 2015, 4085 subjects were enrolled in the study. 84.2% (n = 3442) were male, the mean age was 36 years (SD = 16), and the most common trauma mechanism was blunt type (80.1%; n = 3273). The medians of ISS, NISS, TRISS and RTS were: 14 (IQR = 10–21), 17 (IQR = 11–27), 4.21 (IQR = 2.95–5.05) and 7.84 (IQR = 6.90–7.84), respectively. Mortality was 9.3%, and the discrimination for ISS, NISS, TRISS and RTS was: AUC 0.85, 0.89, 0.86 and 0.92, respectively. No one scale had appropriate calibration. Conclusion: Determining the severity of trauma is an essential tool to guide treatment and establish the necessary resources for attention. In a Colombian population from a capital city, trauma scales have adequate performance for the prediction of mortality in patients with trauma. Mención de responsabilidad : Carlos Oliver Valderrama-Molina, Nelson Giraldo, Alfredo Constain, Andres Puerta, Camilo Restrepo, Alba León, Fabián Jaimes Referencia : Eur J Orthop Surg Traumatol. 2017 Feb;27(2):213-220. DOI (Digital Object Identifier) : 10.1007/s00590-016-1892-6 PMID : 27999959 En línea : https://link.springer.com/article/10.1007%2Fs00590-016-1892-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4042 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000639 AC-2017-028 Archivo digital Producción Científica Artículos científicos Disponible Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study / Fabián Alberto Jaimes Barragán
Título : Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : JAMA Neurology Idioma : Inglés (eng) Resumen : Importance Data from an autosomal dominant Alzheimer disease (ADAD) kindred were used to track the longitudinal trajectory of cognitive decline associated with preclinical ADAD and explore factors that may modify the rate of cognitive decline. Objectives To evaluate the onset and rate of cognitive decline during preclinical ADAD and the effect of socioeconomic, vascular, and genetic factors on the cognitive decline. Design, Setting, and Participants We performed a retrospective cohort study from January 1, 1995, through June 31, 2012, of individuals from Antioquia, Colombia, who tested positive for the ADAD-associated PSEN1 E280A mutation. Data analysis was performed from August 20, 2014, through November 30, 2015. A mixed-effects model was used to estimate annual rates of change in cognitive test scores and to mark the onset of cognitive decline. Main Outcomes and Measures Memory, language, praxis, and total scores from the Consortium to Establish a Registry for Alzheimer Disease test battery. Chronologic age was used as a time scale in the models. We explore the effects of sex; educational level; socioeconomic status; residence area; occupation type; marital status; history of hypertension, diabetes mellitus, and dyslipidemia; tobacco and alcohol use; and APOE ε4 on the rates of cognitive decline. Results A total of 493 carriers met the inclusion criteria and were analyzed. A total of 256 carriers had 2 or more assessments. At the time of the initial assessment, participants had a mean (SD) age of 33.4 (11.7) years and a mean (SD) educational level of 7.2 (4.2) years. They were predominantly female (270 [54.8%]), married (293 [59.4%]), and of low socioeconomic status (322 [65.3%]). Word list recall scores provided the earliest indicator of preclinical cognitive decline at 32 years of age, 12 and 17 years before the kindred’s respective median ages at mild cognitive impairment and dementia onset. After the change point, carriers had a statistically significant cognitive decline with a loss of 0.24 (95% CI, −0.26 to −0.22) points per year for the word list recall test and 2.13 (95% CI, −2.29 to −1.96) points per year for total scores. Carriers with high educational levels had an increase of approximately 36% in the rate of cognitive decline after the change point when compared with those with low educational levels (−2.89 vs −2.13 points per year, respectively). Onset of cognitive decline was delayed by 3 years in individuals with higher educational levels compared with those with lower educational levels. Those with higher educational level, middle/high socioeconomic status, history of diabetes and hypertension, and tobacco and alcohol use had a steeper cognitive decline after onset. Conclusions and Relevance Preclinical cognitive decline was evident in PSEN1 E280A mutation carriers 12 years before the onset of clinical impairment. Educational level may be a protective factor against the onset of cognitive impairment. Mención de responsabilidad : Daniel C Aguirre-Acevedo, Francisco Lopera, Eliana Henao, Victoria Tirado, Claudia Muñoz, Margarita Giraldo, Shrikant I Bangdiwala, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Yakeel T Quiroz, Fabian Jaimes Referencia : JAMA Neurol. 2016 Apr;73(4):431-8. DOI (Digital Object Identifier) : 10.1001/jamaneurol.2015.4851 PMID : 26902171 En línea : https://jamanetwork.com/journals/jamaneurology/fullarticle/2491447 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3988 Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2016.
Obra : JAMA Neurology
Idioma : Inglés (eng)
Resumen : Importance Data from an autosomal dominant Alzheimer disease (ADAD) kindred were used to track the longitudinal trajectory of cognitive decline associated with preclinical ADAD and explore factors that may modify the rate of cognitive decline. Objectives To evaluate the onset and rate of cognitive decline during preclinical ADAD and the effect of socioeconomic, vascular, and genetic factors on the cognitive decline. Design, Setting, and Participants We performed a retrospective cohort study from January 1, 1995, through June 31, 2012, of individuals from Antioquia, Colombia, who tested positive for the ADAD-associated PSEN1 E280A mutation. Data analysis was performed from August 20, 2014, through November 30, 2015. A mixed-effects model was used to estimate annual rates of change in cognitive test scores and to mark the onset of cognitive decline. Main Outcomes and Measures Memory, language, praxis, and total scores from the Consortium to Establish a Registry for Alzheimer Disease test battery. Chronologic age was used as a time scale in the models. We explore the effects of sex; educational level; socioeconomic status; residence area; occupation type; marital status; history of hypertension, diabetes mellitus, and dyslipidemia; tobacco and alcohol use; and APOE ε4 on the rates of cognitive decline. Results A total of 493 carriers met the inclusion criteria and were analyzed. A total of 256 carriers had 2 or more assessments. At the time of the initial assessment, participants had a mean (SD) age of 33.4 (11.7) years and a mean (SD) educational level of 7.2 (4.2) years. They were predominantly female (270 [54.8%]), married (293 [59.4%]), and of low socioeconomic status (322 [65.3%]). Word list recall scores provided the earliest indicator of preclinical cognitive decline at 32 years of age, 12 and 17 years before the kindred’s respective median ages at mild cognitive impairment and dementia onset. After the change point, carriers had a statistically significant cognitive decline with a loss of 0.24 (95% CI, −0.26 to −0.22) points per year for the word list recall test and 2.13 (95% CI, −2.29 to −1.96) points per year for total scores. Carriers with high educational levels had an increase of approximately 36% in the rate of cognitive decline after the change point when compared with those with low educational levels (−2.89 vs −2.13 points per year, respectively). Onset of cognitive decline was delayed by 3 years in individuals with higher educational levels compared with those with lower educational levels. Those with higher educational level, middle/high socioeconomic status, history of diabetes and hypertension, and tobacco and alcohol use had a steeper cognitive decline after onset. Conclusions and Relevance Preclinical cognitive decline was evident in PSEN1 E280A mutation carriers 12 years before the onset of clinical impairment. Educational level may be a protective factor against the onset of cognitive impairment. Mención de responsabilidad : Daniel C Aguirre-Acevedo, Francisco Lopera, Eliana Henao, Victoria Tirado, Claudia Muñoz, Margarita Giraldo, Shrikant I Bangdiwala, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Yakeel T Quiroz, Fabian Jaimes Referencia : JAMA Neurol. 2016 Apr;73(4):431-8. DOI (Digital Object Identifier) : 10.1001/jamaneurol.2015.4851 PMID : 26902171 En línea : https://jamanetwork.com/journals/jamaneurology/fullarticle/2491447 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3988 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000580 AC-2016-055 Archivo digital Producción Científica Artículos científicos Disponible Desarrollo y validación de un modelo predictor para bacteriemia en pacientes hospitalizados por el servicio de urgencias con sospecha de infección / Fabián Alberto Jaimes Barragán
Título : Desarrollo y validación de un modelo predictor para bacteriemia en pacientes hospitalizados por el servicio de urgencias con sospecha de infección Otros títulos : Development and validation of a predictive model for bacteremia in patients hospitalized by the emergency department with suspected infection Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : Revista Chilena de Infectología Idioma : Español (spa) Palabras clave : Bacteriemia predicción sepsis hemocultivo Resumen : Introducción: Un hemocultivo positivo usualmente indica infección diseminada, la que se asocia con peor pronóstico y mayor mortalidad. Por tanto, buscamos desarrollar y validar un modelo de predicción que permita identificar los factores asociados con la positividad de los hemocultivos en pacientes del servicio de urgencias. Métodos: Análisis secundario de datos de dos cohortes prospectivas (EPISEPSIS: cohorte de desarrollo y DISEPSIS: cohorte de validación) de pacientes con sospecha o confirmación de infección, ensambladas en servicios de urgencias de 10 instituciones hospitalarias en cuatro ciudades de Colombia entre septiembre de 2007 y febrero de 2008. Se ajustó un modelo logístico multivariado para identificar variables clínicas y de laboratorio predictoras de hemocultivos positivos. Resultados: Se analizaron 719 pacientes en la cohorte de desarrollo y 467 en la cohorte de validación, con 32 y 21% de hemocultivos positivos, respectivamente. El modelo predictor final incluyó las variables con coeficientes significativos para ambas cohortes: temperatura ≥ 38 °C, Glasgow Mención de responsabilidad : Alba Cuervo, Julieta Correa, Danlela Garcés, Johana Ascuntar, Alba León, Fabián A Jaimes Referencia : Rev Chilena Infectol. 2016 Apr;33(2):150-8. DOI (Digital Object Identifier) : 10.4067/S0716-10182016000200004 PMID : 27314992 Derechos de uso : CC BY-NC En línea : https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182016000200 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4004 Desarrollo y validación de un modelo predictor para bacteriemia en pacientes hospitalizados por el servicio de urgencias con sospecha de infección = Development and validation of a predictive model for bacteremia in patients hospitalized by the emergency department with suspected infection [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2016.
Obra : Revista Chilena de Infectología
Idioma : Español (spa)
Palabras clave : Bacteriemia predicción sepsis hemocultivo Resumen : Introducción: Un hemocultivo positivo usualmente indica infección diseminada, la que se asocia con peor pronóstico y mayor mortalidad. Por tanto, buscamos desarrollar y validar un modelo de predicción que permita identificar los factores asociados con la positividad de los hemocultivos en pacientes del servicio de urgencias. Métodos: Análisis secundario de datos de dos cohortes prospectivas (EPISEPSIS: cohorte de desarrollo y DISEPSIS: cohorte de validación) de pacientes con sospecha o confirmación de infección, ensambladas en servicios de urgencias de 10 instituciones hospitalarias en cuatro ciudades de Colombia entre septiembre de 2007 y febrero de 2008. Se ajustó un modelo logístico multivariado para identificar variables clínicas y de laboratorio predictoras de hemocultivos positivos. Resultados: Se analizaron 719 pacientes en la cohorte de desarrollo y 467 en la cohorte de validación, con 32 y 21% de hemocultivos positivos, respectivamente. El modelo predictor final incluyó las variables con coeficientes significativos para ambas cohortes: temperatura ≥ 38 °C, Glasgow Mención de responsabilidad : Alba Cuervo, Julieta Correa, Danlela Garcés, Johana Ascuntar, Alba León, Fabián A Jaimes Referencia : Rev Chilena Infectol. 2016 Apr;33(2):150-8. DOI (Digital Object Identifier) : 10.4067/S0716-10182016000200004 PMID : 27314992 Derechos de uso : CC BY-NC En línea : https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182016000200 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4004 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000599 AC-2016-074 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2016-074.pdfAdobe Acrobat PDF Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene / Fabián Alberto Jaimes Barragán
Título : Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : International Psychogeriatrics Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease CERAD mild cognitive impairment validity sensitivity Resumen : Background:This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). Methods: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). Results: The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). Conclusions: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD. Mención de responsabilidad : Daniel Camilo Aguirre-Acevedo, Fabian Jaimes-Barragán, Eliana Henao, Victoria Tirado, Claudia Muñoz, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Francisco Lopera Referencia : Int Psychogeriatr. 2016 Mar;28(3):503-10. DOI (Digital Object Identifier) : 10.1017/S1041610215001660 PMID : 26478578 En línea : https://www.cambridge.org/core/journals/international-psychogeriatrics/aticle/di [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3996 Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2016.
Obra : International Psychogeriatrics
Idioma : Inglés (eng)
Palabras clave : Alzheimer’s disease CERAD mild cognitive impairment validity sensitivity Resumen : Background:This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). Methods: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). Results: The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). Conclusions: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD. Mención de responsabilidad : Daniel Camilo Aguirre-Acevedo, Fabian Jaimes-Barragán, Eliana Henao, Victoria Tirado, Claudia Muñoz, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Francisco Lopera Referencia : Int Psychogeriatr. 2016 Mar;28(3):503-10. DOI (Digital Object Identifier) : 10.1017/S1041610215001660 PMID : 26478578 En línea : https://www.cambridge.org/core/journals/international-psychogeriatrics/aticle/di [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3996 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000589 AC-2016-064 Archivo digital Producción Científica Artículos científicos Disponible Epidemiología y pronóstico de pacientes con infección del torrente sanguíneo en 10 hospitales de Colombia / Gisela de la Rosa Echavez ; Fabián Alberto Jaimes BarragánPermalinkMortalidad asociada a la presión arterial de ingreso a urgencias en pacientes con trauma encéfalo-craneano: un estudio de cohorte retrospectiva / Fabián Alberto Jaimes BarragánPermalinkPermalinkPermalinkPermalinkRonda clínica y epidemiológica: sistemas de información geográfica (SIG) en salud / Fabián Alberto Jaimes BarragánPermalinkUrinary tract infection leading to hospital admission during the first year after kidney transplantation: A retrospective cohort study / Fabián Alberto Jaimes BarragánPermalinkUso adecuado de antibióticos en pacientes con exacerbaciones de EPOC atendidos en un hospital de Medellín, Colombia / Fabián Alberto Jaimes BarragánPermalinkVariants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis / Fabián Alberto Jaimes BarragánPermalinkCaracterísticas clínicas y demográficas de pacientes con trauma raquimedular. Experiencia de seis años / Carlos Alberto Carvajal Mojica ; Carlos Andrés Pacheco Melo ; Camilo Enrique Gómez Rojo ; Julio Calderón ; Carlos Alberto Cadavid Gutiérrez ; Fabián Alberto Jaimes BarragánPermalink