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Autor Ángela Restrepo Moreno |
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Inhibition by estrogens of conidium-to-yeast conversion in the fungus Paracoccidioides brasiliensis / Maria E. Salazar ; Ángela Restrepo Moreno
Título : Inhibition by estrogens of conidium-to-yeast conversion in the fungus Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Maria E. Salazar, ; Ángela Restrepo Moreno, Fecha de publicación : 1988 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Conidia produced by Paracoccidioides brasiliensis are inhibited by mammalian estrogens in their in vitro conversion into yeast-form cells. This was demonstrated with four different isolates. In these experiments, conversion was reduced to 10.7 and 34.4% of the control values by 17-beta-estradiol at 10(-6) and 10(-8) M, respectively. At the same concentrations, the synthetic estrogen diethylstilbestrol was slightly less inhibitory. In contrast, other sex hormones and analogs, i.e., testosterone, 17-alpha-estradiol, tamoxifen, and hydroxytamoxifen, had no effect on conidium-to-yeast conversion. Previous studies have shown that estrogens similarly inhibit mycelium-to-yeast-form transition in P. brasiliensis. Conidia, and not mycelial fragments, are believed to be the natural infectious propagules. These findings with conidia support the hypothesis that estrogens, affecting the initial host-parasite interactions by suppressing conversion to the parasitic form of the organism, are, at least in part, responsible for the greater resistance of females to paracoccidioidomycosis. Mención de responsabilidad : M E Salazar, A Restrepo, D A Stevens Referencia : Infect Immun. 1988 Mar;56(3):711-3 PMID : 3343055 En línea : https://iai.asm.org/content/56/3/711.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4346 Inhibition by estrogens of conidium-to-yeast conversion in the fungus Paracoccidioides brasiliensis [documento electrónico] / Maria E. Salazar, ; Ángela Restrepo Moreno, . - 1988.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Conidia produced by Paracoccidioides brasiliensis are inhibited by mammalian estrogens in their in vitro conversion into yeast-form cells. This was demonstrated with four different isolates. In these experiments, conversion was reduced to 10.7 and 34.4% of the control values by 17-beta-estradiol at 10(-6) and 10(-8) M, respectively. At the same concentrations, the synthetic estrogen diethylstilbestrol was slightly less inhibitory. In contrast, other sex hormones and analogs, i.e., testosterone, 17-alpha-estradiol, tamoxifen, and hydroxytamoxifen, had no effect on conidium-to-yeast conversion. Previous studies have shown that estrogens similarly inhibit mycelium-to-yeast-form transition in P. brasiliensis. Conidia, and not mycelial fragments, are believed to be the natural infectious propagules. These findings with conidia support the hypothesis that estrogens, affecting the initial host-parasite interactions by suppressing conversion to the parasitic form of the organism, are, at least in part, responsible for the greater resistance of females to paracoccidioidomycosis. Mención de responsabilidad : M E Salazar, A Restrepo, D A Stevens Referencia : Infect Immun. 1988 Mar;56(3):711-3 PMID : 3343055 En línea : https://iai.asm.org/content/56/3/711.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4346 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000847 AC-1988-002 Archivo digital Producción Científica Artículos científicos Disponible Morphological study of a variant of Paracoccidioides brasiliensis that exists in the yeast form at room temperature / L. A. Villar ; Maria E. Salazar ; Ángela Restrepo Moreno
Título : Morphological study of a variant of Paracoccidioides brasiliensis that exists in the yeast form at room temperature Tipo de documento : documento electrónico Autores : L. A. Villar, ; Maria E. Salazar, ; Ángela Restrepo Moreno, Fecha de publicación : 1988 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Incubation of Paracoccidioides brasiliensis conidia at 20–25°C (RT) results in two types of colonies, mycelial (M) and yeast (YRT). A study of the latter colonies was undertaken. Conidia were plated in complex (BHI) and chemically-defined media (CDCM), with and without fetal calf serum (FCS). Incubation was carried out at 21°C for 4 weeks. The mean number of YRT colonies was approximately 18·5% on BHI agar. Selected YRT colonies were transferred to liquid CDCM, incubated 7 days at 21°C and transferred to solid media; YRT appearance was preserved in 95% of the colonies if media were FCS-supplemented; otherwise, most colonies reverted to the M form. When FCS was replaced by bovine albumin or by alpha-globulin, 63% and 68% respectively of the colonies obtained after plating YRT cells, became mycelial. Comparative morphologic studies of both YRT and yeasts grown at 37°C suggested that there were no major differences between these two types of yeast cells when size and budding were taken into consideration. The results indicate that in this particular variant, dimorphism is not exclusively temperature-dependent. Mención de responsabilidad : L.A. Villar, M.E. Salazar, A. Restrepo Referencia : J Med Vet Mycol. 1988;26(5):269-76 DOI (Digital Object Identifier) : 10.1080/02681218880000381 PMID : 3236146 En línea : https://academic.oup.com/mmy/article-abstract/26/5/269/895907 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4347 Morphological study of a variant of Paracoccidioides brasiliensis that exists in the yeast form at room temperature [documento electrónico] / L. A. Villar, ; Maria E. Salazar, ; Ángela Restrepo Moreno, . - 1988.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : Incubation of Paracoccidioides brasiliensis conidia at 20–25°C (RT) results in two types of colonies, mycelial (M) and yeast (YRT). A study of the latter colonies was undertaken. Conidia were plated in complex (BHI) and chemically-defined media (CDCM), with and without fetal calf serum (FCS). Incubation was carried out at 21°C for 4 weeks. The mean number of YRT colonies was approximately 18·5% on BHI agar. Selected YRT colonies were transferred to liquid CDCM, incubated 7 days at 21°C and transferred to solid media; YRT appearance was preserved in 95% of the colonies if media were FCS-supplemented; otherwise, most colonies reverted to the M form. When FCS was replaced by bovine albumin or by alpha-globulin, 63% and 68% respectively of the colonies obtained after plating YRT cells, became mycelial. Comparative morphologic studies of both YRT and yeasts grown at 37°C suggested that there were no major differences between these two types of yeast cells when size and budding were taken into consideration. The results indicate that in this particular variant, dimorphism is not exclusively temperature-dependent. Mención de responsabilidad : L.A. Villar, M.E. Salazar, A. Restrepo Referencia : J Med Vet Mycol. 1988;26(5):269-76 DOI (Digital Object Identifier) : 10.1080/02681218880000381 PMID : 3236146 En línea : https://academic.oup.com/mmy/article-abstract/26/5/269/895907 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4347 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000848 AC-1988-003 Archivo digital Producción Científica Artículos científicos Disponible Treatment of chromoblastomycosis with itraconazole / Ángela Restrepo Moreno ; Aurelio González ; Iván Gómez ; Myrtha Arango Arteaga ; Catalina de Bedout Gómez
Título : Treatment of chromoblastomycosis with itraconazole Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Aurelio González, ; Iván Gómez, ; Myrtha Arango Arteaga, ; Catalina de Bedout Gómez, Fecha de publicación : 1988 Títulos uniformes : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Resumen : The results of long-term itraconazole therapy in 10 patients with active chromoblastomycosis due to F. pedrosoi were reported. Therapy consisted of 100 or 200 mg/day of itraconazole, the length of therapy depending on the patient's response (12 to 24 months). This new triazole proved effective in reducing the number, size, and severity of the lesions in nine of the patients. Those patients with minor involvement profited more from therapy and were cured; patients with moderate involvement achieved either minor or major improvement. In most cases, signs and symptoms began to improve after 6 months of therapy. Mycological tests (in which tissue samples were treated with potassium hydroxide and cultured) became negative in six patients, but the fungus was eradicated in only three patients. Itraconazole produced no side effects. In spite of the need for long-term therapy, this new azole derivative effectively controls the disease. Mención de responsabilidad : Angela Restrepo, Aurelio Gonzalez, Ivan Gomez, Myrtha Arango, Catalina De Bedout Referencia : Ann N Y Acad Sci. 1988;544:504-16 DOI (Digital Object Identifier) : 10.1111/j.1749-6632.1988.tb40448.x PMID : 2850755 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1988.tb4044 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4348 Treatment of chromoblastomycosis with itraconazole [documento electrónico] / Ángela Restrepo Moreno, ; Aurelio González, ; Iván Gómez, ; Myrtha Arango Arteaga, ; Catalina de Bedout Gómez, . - 1988.
Obra : Annals of the New York Academy of Sciences
Idioma : Inglés (eng)
Resumen : The results of long-term itraconazole therapy in 10 patients with active chromoblastomycosis due to F. pedrosoi were reported. Therapy consisted of 100 or 200 mg/day of itraconazole, the length of therapy depending on the patient's response (12 to 24 months). This new triazole proved effective in reducing the number, size, and severity of the lesions in nine of the patients. Those patients with minor involvement profited more from therapy and were cured; patients with moderate involvement achieved either minor or major improvement. In most cases, signs and symptoms began to improve after 6 months of therapy. Mycological tests (in which tissue samples were treated with potassium hydroxide and cultured) became negative in six patients, but the fungus was eradicated in only three patients. Itraconazole produced no side effects. In spite of the need for long-term therapy, this new azole derivative effectively controls the disease. Mención de responsabilidad : Angela Restrepo, Aurelio Gonzalez, Ivan Gomez, Myrtha Arango, Catalina De Bedout Referencia : Ann N Y Acad Sci. 1988;544:504-16 DOI (Digital Object Identifier) : 10.1111/j.1749-6632.1988.tb40448.x PMID : 2850755 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1988.tb4044 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4348 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000849 AC-1988-004 Archivo digital Producción Científica Artículos científicos Disponible Nuclear staining of Paracoccidioides brasiliensis conidia / Juan Guillermo McEwen Ochoa ; Blanca I. Restrepo ; Maria E. Salazar ; Ángela Restrepo Moreno
Título : Nuclear staining of Paracoccidioides brasiliensis conidia Tipo de documento : documento electrónico Autores : Juan Guillermo McEwen Ochoa, ; Blanca I. Restrepo, ; Maria E. Salazar, ; Ángela Restrepo Moreno, Fecha de publicación : 1987 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : More than 80% of the conidia produced by two different isolates of Paracoccidioides brasiliensis, were found to be uninucleate; however, when they were incubated at 37°C and began to transform into yeast cells, they became bi- or multi-nucleated, so that when most of the conidia had already transformed into yeast cells (72–96 h), there were at least four or five nuclei per cell in approximately 80% of the conidia examined. Mención de responsabilidad : Juan G. McEwen, Blanca I. Restrepo, Maria E. Salazar, Angela Restrepo Referencia : J Med Vet Mycol. 1987 Oct;25(5):343-5 DOI (Digital Object Identifier) : 10.1080/02681218780000411 PMID : 2448446 En línea : https://academic.oup.com/mmy/article-abstract/25/5/343/1299208 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4343 Nuclear staining of Paracoccidioides brasiliensis conidia [documento electrónico] / Juan Guillermo McEwen Ochoa, ; Blanca I. Restrepo, ; Maria E. Salazar, ; Ángela Restrepo Moreno, . - 1987.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : More than 80% of the conidia produced by two different isolates of Paracoccidioides brasiliensis, were found to be uninucleate; however, when they were incubated at 37°C and began to transform into yeast cells, they became bi- or multi-nucleated, so that when most of the conidia had already transformed into yeast cells (72–96 h), there were at least four or five nuclei per cell in approximately 80% of the conidia examined. Mención de responsabilidad : Juan G. McEwen, Blanca I. Restrepo, Maria E. Salazar, Angela Restrepo Referencia : J Med Vet Mycol. 1987 Oct;25(5):343-5 DOI (Digital Object Identifier) : 10.1080/02681218780000411 PMID : 2448446 En línea : https://academic.oup.com/mmy/article-abstract/25/5/343/1299208 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4343 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000844 AC-1987-001 Archivo digital Producción Científica Artículos científicos Disponible Predictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis / Luz Elena Cano Restrepo ; Ángela Restrepo Moreno
Título : Predictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, Autor ; Ángela Restrepo Moreno, Autor Fecha de publicación : 1987 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Predictive values Serologic tests Paracoccidoidomycosis Cross-reactions Systemic mycoses Resumen : A serologic study was undertaken in a group of 43 patients with active paracoccidioidomycosis who were treated in the same form (ketoconazole), for identical periods of time (6 months), and folio wed-up for various periods posttherapy. The tests employed were agar gel immunodiffusion (AGID) and complement fixation (FC). Also studied were 50 sera from patients with proven histoplasmosis and pulmonary aspergilloma, 30 patients with culturaly proven tuberculosis as well as 92 specimens from healthy individuals, residents in the endemic area for paracoccidioidomycosis. A single lot of yeast filtrate antigen was used throughout the study. The value of each test was measured according to GALEN and GAMBINO6. Both tests were highly sensitive, 89 and 93% respectively. Regarding their specificity, the AGID was totally specific while the CF exhibited 96.6% and 97% specificity in front of tuberculosis patients and healthy individuals respectively and 82% in comparison with patients with other mycoses. The concept of predictive value, that is, the certainty one has in accepting a positive test as diagnostic of paracoccidioidomycosis, favored the AGID procedure (100%) over the CF test. The latter could sort out with 93% certainty a patient with paracoccidioidomycosis among a group of healthy individuals and with 97.5% in the case of TB patients; when the group in question was composed by individuals with other deep mycoses, such certainty was lower (81%). The above results indicate that both the AGID and the CF tests furnish results of high confidence; one should not relay, however, in the CF alone as a means to establish the specific diagnosis of paracoccidioidomycosis. Mención de responsabilidad : CANO, Luz Elena and RESTREPO, Angela Referencia : Rev Inst Med Trop Sao Paulo. Sep-Oct 1987;29(5):276-83. DOI (Digital Object Identifier) : 10.1590/S0036-46651987000500003 PMID : 3136529 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651987000500003 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4344 Predictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis [documento electrónico] / Luz Elena Cano Restrepo, Autor ; Ángela Restrepo Moreno, Autor . - 1987.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Predictive values Serologic tests Paracoccidoidomycosis Cross-reactions Systemic mycoses Resumen : A serologic study was undertaken in a group of 43 patients with active paracoccidioidomycosis who were treated in the same form (ketoconazole), for identical periods of time (6 months), and folio wed-up for various periods posttherapy. The tests employed were agar gel immunodiffusion (AGID) and complement fixation (FC). Also studied were 50 sera from patients with proven histoplasmosis and pulmonary aspergilloma, 30 patients with culturaly proven tuberculosis as well as 92 specimens from healthy individuals, residents in the endemic area for paracoccidioidomycosis. A single lot of yeast filtrate antigen was used throughout the study. The value of each test was measured according to GALEN and GAMBINO6. Both tests were highly sensitive, 89 and 93% respectively. Regarding their specificity, the AGID was totally specific while the CF exhibited 96.6% and 97% specificity in front of tuberculosis patients and healthy individuals respectively and 82% in comparison with patients with other mycoses. The concept of predictive value, that is, the certainty one has in accepting a positive test as diagnostic of paracoccidioidomycosis, favored the AGID procedure (100%) over the CF test. The latter could sort out with 93% certainty a patient with paracoccidioidomycosis among a group of healthy individuals and with 97.5% in the case of TB patients; when the group in question was composed by individuals with other deep mycoses, such certainty was lower (81%). The above results indicate that both the AGID and the CF tests furnish results of high confidence; one should not relay, however, in the CF alone as a means to establish the specific diagnosis of paracoccidioidomycosis. Mención de responsabilidad : CANO, Luz Elena and RESTREPO, Angela Referencia : Rev Inst Med Trop Sao Paulo. Sep-Oct 1987;29(5):276-83. DOI (Digital Object Identifier) : 10.1590/S0036-46651987000500003 PMID : 3136529 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651987000500003 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4344 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000845 AC-1987-002 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1987-002.pdfAdobe Acrobat PDF Adrenal function in paracoccidioidomycosis: A prospective study in patients before and after ketoconazole therapy / Iván Gómez ; Ángela Restrepo MorenoPermalinkAn evaluation of the enzyme-linked immunoabsorbent assay (ELISA) for quantitation of antibodies to paracoccidioides brasiliensis / Luz Elena Cano Restrepo ; Ángela Restrepo MorenoPermalinkItraconazole therapy in lymphangitic and cutaneous sporotrichosis / Ángela Restrepo Moreno ; Jaime Robledo ; Iván Gómez ; Ángela María Tabares Velásquez ; Regina GutiérrezPermalinkMorphological development of the conidia produced by paracoccidioides brasiliensis mycelial form / Blanca I. Restrepo ; Juan Guillermo McEwen Ochoa ; Maria E. Salazar ; Ángela Restrepo MorenoPermalinkPathogenesis of paracoccidioidomycosis: A histopathological study of the experimental murine infection / Víctor Bedoya M. ; Juan Guillermo McEwen Ochoa ; Ángela María Tabares Velásquez ; Fabio Uribe Jaramillo ; Ángela Restrepo MorenoPermalinkWater as a substrate for the development of Paracoccidiodes brasiliensis mycelial form / Catalina de Bedout Gómez ; Luz Elena Cano Restrepo ; Ángela María Tabares Velásquez ; Ángela Restrepo MorenoPermalinkPermalinkLack of antibody induction by histolyn-CYL® a new skin-testing reagent for histoplasmosis / Ángela Restrepo MorenoPermalinkThe radiological appearances of pulmonary paracoccidioidomycosis and the effects of ketoconazole therapy / Iván Gómez ; Ángela Restrepo MorenoPermalinkA yeast-derived antigen from paracoccidioides brasiliensis useful for serologic testing / Ángela Restrepo Moreno ; Luz Elena Cano Restrepo ; María Teresa OchoaPermalinkChronic murine paracoccidioidomycosis: Effect of ketoconazole on clearance of paracoccidioides brasiliensis and immune response / Guillermo L. Hoyos ; Juan Guillermo McEwen Ochoa ; Ángela Restrepo MorenoPermalinkEffect of temperature on the mycelium to yeast transformation of paracoccidioides brasiliensis / María Mercedes Patiño ; Luis C. Burgos ; Ángela Restrepo MorenoPermalinkEstrogens inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: Implications for resistance of females to Paracoccidioidomycosis / Ángela Restrepo Moreno ; Maria E. Salazar ; Luz Elena Cano RestrepoPermalinkIn vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents / Ángela Restrepo Moreno ; Catalina de Bedout Gómez ; Ángela María Tabares VelásquezPermalinkBlood groups and HLA antigens in paracoccidioidomycosis / Fabiola Montoya de Restrepo ; Marcos Restrepo ; Ángela Restrepo MorenoPermalinkA comparison of mycelial filtrate - and yeast lysate - paracoccidioidin in patients with paracoccidioidomycosis / Ángela Restrepo Moreno ; Luz Elena Cano Restrepo ; Ángela María Tabares VelásquezPermalinkSpontaneous regression of pulmonary paracoccidioidomycosis - Report of a case / Ángela Restrepo MorenoPermalinkComparison of various techniques for determining viability of Paracoccidioides brasiliensis yeast-form cells / Ángela Restrepo Moreno ; Luz Elena Cano Restrepo ; Catalina de Bedout GómezPermalinkEficacia del ketoconazol en pacientes con paracoccidioidomicosis recidivante / Ángela Restrepo Moreno ; Iván GómezPermalinkRecovery of fungi from seeded sputum samples: Effect of culture media and digestion procedures / Ángela Restrepo Moreno ; Luz Elena Cano RestrepoPermalink