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Autor Ángela Restrepo Moreno |
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Saperconazole in the treatment of systemic and subcutaneous mycoses / Liliana Franco R. ; Iván Gómez ; Ángela Restrepo Moreno
Título : Saperconazole in the treatment of systemic and subcutaneous mycoses Tipo de documento : documento electrónico Autores : Liliana Franco R., ; Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : International Journal of Dermatology Idioma : Inglés (eng) Resumen : In a 2‐year period, 30 patients with culture‐proven mycoses (chromoblastomycosis, sporotrichosis, and paracoccid‐ioidomycosis) were treated with the new orally administered triazole, saperconazole (SPZ) (R66905). The daily dose varied from 100 to 200 mg. All patients responded to treatment; the mean time required to heal the lesions and convert the cultures to negative was 3.5 months for sporotrichosis, 4.6 for paracoccidioidomycosis, and 9.0 for chromoblastomycosis. Evaluation by a scoring system indicated that 36.6% of the patients achieved complete resolution of the pretherapy abnormalities, while the remaining (63.3%) experienced major improvement. No colateral effects were reported; there were no bone‐marrow or liver toxicities. SPZ is an effective drug for the treatment of the above‐mentioned mycoses and appears to be suitable for the control of chromoblastomycosis. Mención de responsabilidad : Liliana Franco M.D. Ivan Gomez M.D. Angela Restrepo Ph.D. Referencia : Int J Dermatol. 1992 Oct;31(10):725-9. DOI (Digital Object Identifier) : 10.1111/j.1365-4362.1992.tb01384.x PMID : 1399205 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4362.1992.tb01384.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4362 Saperconazole in the treatment of systemic and subcutaneous mycoses [documento electrónico] / Liliana Franco R., ; Iván Gómez, ; Ángela Restrepo Moreno, . - 1992.
Obra : International Journal of Dermatology
Idioma : Inglés (eng)
Resumen : In a 2‐year period, 30 patients with culture‐proven mycoses (chromoblastomycosis, sporotrichosis, and paracoccid‐ioidomycosis) were treated with the new orally administered triazole, saperconazole (SPZ) (R66905). The daily dose varied from 100 to 200 mg. All patients responded to treatment; the mean time required to heal the lesions and convert the cultures to negative was 3.5 months for sporotrichosis, 4.6 for paracoccidioidomycosis, and 9.0 for chromoblastomycosis. Evaluation by a scoring system indicated that 36.6% of the patients achieved complete resolution of the pretherapy abnormalities, while the remaining (63.3%) experienced major improvement. No colateral effects were reported; there were no bone‐marrow or liver toxicities. SPZ is an effective drug for the treatment of the above‐mentioned mycoses and appears to be suitable for the control of chromoblastomycosis. Mención de responsabilidad : Liliana Franco M.D. Ivan Gomez M.D. Angela Restrepo Ph.D. Referencia : Int J Dermatol. 1992 Oct;31(10):725-9. DOI (Digital Object Identifier) : 10.1111/j.1365-4362.1992.tb01384.x PMID : 1399205 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4362.1992.tb01384.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4362 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000862 AC-1992-001 Archivo digital Producción Científica Artículos científicos Disponible Tratamiento y evolución de la criptococosis y la histoplasmosis en pacientes infectados por el virus de la inmunodeficiencia humana (VIH) / Jaime Alberto López Vargas ; Liliana Franco R. ; Ángela Restrepo Moreno
Título : Tratamiento y evolución de la criptococosis y la histoplasmosis en pacientes infectados por el virus de la inmunodeficiencia humana (VIH) Tipo de documento : documento electrónico Autores : Jaime Alberto López Vargas, ; Liliana Franco R., ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Criptococosis en SIDA Hitoplasmosis en SIDA Terapia micosis en SIDA Resumen : Se presenta un estudio retrospectivo de pacientes Infectados por el Virus de Inmunodeficiencia Humana (VIH) quienes desarrollaron criptococosis y/o histoplasmosis sobre agregada; se discute el tratamiento empleado y la respuesta obtenida con los diferentes antimicóticos utilizados. De los 10 pacientes con criptococosis. 5 de los regímenes terapéuticos emprendidos fueron no evaluables. 4 no exitosos y 3 exitosos. En estos últimos, el fluconazol fue el antifúngico administrado. En los 10 pacientes con diagnóstico de histoplasmosis se implementaron 16 esquemas de terapia antimicótica; 7 de ellos fueron no evaluables. 6 no exitosos y 3 exitosos. El saperconazol, un nuevo triazol aún en fase de experimentación, resultó exitoso en las 3 oportunidades en que fue empleado en pacientes con histoplasmosis. Un paciente tuvo el diagnóstico simultáneo de criptococosis meníngea e histoplasmosis diseminada, pero en él la droga empleada (fluconazol) no logró controlar las micosis presentes. Finalmente se anota cómo los pacientes con criptococosis tuvieron una menor sobrevida que aquellos con histoplasmosis. Mención de responsabilidad : Jaime A. López V., Liliana Franco R., Ángela Restrepo M., Beatriz Orozco Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5215 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5052 Tratamiento y evolución de la criptococosis y la histoplasmosis en pacientes infectados por el virus de la inmunodeficiencia humana (VIH) [documento electrónico] / Jaime Alberto López Vargas, ; Liliana Franco R., ; Ángela Restrepo Moreno, . - 1992.
Obra : Medicina U.P.B.
Idioma : Español (spa)
Palabras clave : Criptococosis en SIDA Hitoplasmosis en SIDA Terapia micosis en SIDA Resumen : Se presenta un estudio retrospectivo de pacientes Infectados por el Virus de Inmunodeficiencia Humana (VIH) quienes desarrollaron criptococosis y/o histoplasmosis sobre agregada; se discute el tratamiento empleado y la respuesta obtenida con los diferentes antimicóticos utilizados. De los 10 pacientes con criptococosis. 5 de los regímenes terapéuticos emprendidos fueron no evaluables. 4 no exitosos y 3 exitosos. En estos últimos, el fluconazol fue el antifúngico administrado. En los 10 pacientes con diagnóstico de histoplasmosis se implementaron 16 esquemas de terapia antimicótica; 7 de ellos fueron no evaluables. 6 no exitosos y 3 exitosos. El saperconazol, un nuevo triazol aún en fase de experimentación, resultó exitoso en las 3 oportunidades en que fue empleado en pacientes con histoplasmosis. Un paciente tuvo el diagnóstico simultáneo de criptococosis meníngea e histoplasmosis diseminada, pero en él la droga empleada (fluconazol) no logró controlar las micosis presentes. Finalmente se anota cómo los pacientes con criptococosis tuvieron una menor sobrevida que aquellos con histoplasmosis. Mención de responsabilidad : Jaime A. López V., Liliana Franco R., Ángela Restrepo M., Beatriz Orozco Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5215 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5052 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001614 AC-1992-007 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1992-007.pdfAdobe Acrobat PDF Electron microscopic study of conidia produced by the mycelium of Paracoccidioides brasiliensis / Maria E. Salazar ; Luz Elena Cano Restrepo ; Ángela Restrepo Moreno
Título : Electron microscopic study of conidia produced by the mycelium of Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Maria E. Salazar, ; Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, Fecha de publicación : 1991 Títulos uniformes : Mycopathologia Idioma : Inglés (eng) Palabras clave : Paracoccidioidomycosis mycelium conidia ultrastructure Resumen : The ultrastructure of asexual spores (conidia) produced by the mycelial form of Paracoccidioides brasiliensis was studied for the first time with transmission electron microscopy, using thin sections of aldehyde-osmium-fixed and epoxy-resin-embedded samples. The various types of conidia observed in the sections correlated well with previous light-microscopic descriptions. These types were intercalary or apical conidia, depending on their location along the originating hyphae. As in previous studies they were characterized as arthroconidia, aleuriospores and sessile or pedunculate pyriform conidia. The sporogenous cells were clearly distinguished from hyphal cells by the thickness and appearance of their cell walls. Copious fibrillar material (glycocalyx) detected at the cell surface was stained with ruthenium red during the fixation process. Typical subcellular organelles (nucleus, nucleolus, mitochondria, ribosomes, etc) were found in most of the sections. It was concluded that the spores produced by the mycelial phase of P. brasiliensis possess all attributes of viable and physiologically competent eukaryotic cells. Mención de responsabilidad : Mercedes R. Edwards, M. E. Salazar, W. A. Samsonoff, L. E. Cano, G. A. Ostrander & A. Restrepo Referencia : Mycopathologia. 1991 Jun;114(3):169-77. DOI (Digital Object Identifier) : 10.1007/BF00437210 PMID : 1886643 En línea : https://link.springer.com/article/10.1007/BF00437210 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4360 Electron microscopic study of conidia produced by the mycelium of Paracoccidioides brasiliensis [documento electrónico] / Maria E. Salazar, ; Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, . - 1991.
Obra : Mycopathologia
Idioma : Inglés (eng)
Palabras clave : Paracoccidioidomycosis mycelium conidia ultrastructure Resumen : The ultrastructure of asexual spores (conidia) produced by the mycelial form of Paracoccidioides brasiliensis was studied for the first time with transmission electron microscopy, using thin sections of aldehyde-osmium-fixed and epoxy-resin-embedded samples. The various types of conidia observed in the sections correlated well with previous light-microscopic descriptions. These types were intercalary or apical conidia, depending on their location along the originating hyphae. As in previous studies they were characterized as arthroconidia, aleuriospores and sessile or pedunculate pyriform conidia. The sporogenous cells were clearly distinguished from hyphal cells by the thickness and appearance of their cell walls. Copious fibrillar material (glycocalyx) detected at the cell surface was stained with ruthenium red during the fixation process. Typical subcellular organelles (nucleus, nucleolus, mitochondria, ribosomes, etc) were found in most of the sections. It was concluded that the spores produced by the mycelial phase of P. brasiliensis possess all attributes of viable and physiologically competent eukaryotic cells. Mención de responsabilidad : Mercedes R. Edwards, M. E. Salazar, W. A. Samsonoff, L. E. Cano, G. A. Ostrander & A. Restrepo Referencia : Mycopathologia. 1991 Jun;114(3):169-77. DOI (Digital Object Identifier) : 10.1007/BF00437210 PMID : 1886643 En línea : https://link.springer.com/article/10.1007/BF00437210 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4360 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000860 AC-1991-002 Archivo digital Producción Científica Artículos científicos Disponible Scanning electron microscopy of the conidia produced by the mycelial form of Paracoccidioides brasiliensis / Maria E. Salazar ; Ángela Restrepo Moreno ; Luz Elena Cano Restrepo
Título : Scanning electron microscopy of the conidia produced by the mycelial form of Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Maria E. Salazar, ; Ángela Restrepo Moreno, ; Luz Elena Cano Restrepo, Fecha de publicación : 1991 Títulos uniformes : Mycopathologia Idioma : Inglés (eng) Palabras clave : Mycelial conidia Paracoccidioides brasiliensis scanning electron microscopy Resumen : The conidia produced by the mycelial form of Paracoccidioides brasiliensis were examined by scanning electron microscopy for the first time. Several different conidial types were characterized. These included intercalary arthroconidia, several types of septate conidia that are formed from other conidia, pedunculate conidia, and terminal hyphal conidia. In addition, the ultrastructure of the supporting pedestal of the pedunculate conidium was found to be separated from the mother conidium by a septum in some instances, and at other times it was not. Mención de responsabilidad : William A. Samsonoff, M. E. Salazar, M. L. McKee, A. Restrepo, L. E. Cano & M. R. Edwards Referencia : Mycopathologia. 1991 Apr;114(1):9-15. DOI (Digital Object Identifier) : 10.1007/BF00436685 PMID : 1857400 En línea : https://link.springer.com/article/10.1007/BF00436685 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4361 Scanning electron microscopy of the conidia produced by the mycelial form of Paracoccidioides brasiliensis [documento electrónico] / Maria E. Salazar, ; Ángela Restrepo Moreno, ; Luz Elena Cano Restrepo, . - 1991.
Obra : Mycopathologia
Idioma : Inglés (eng)
Palabras clave : Mycelial conidia Paracoccidioides brasiliensis scanning electron microscopy Resumen : The conidia produced by the mycelial form of Paracoccidioides brasiliensis were examined by scanning electron microscopy for the first time. Several different conidial types were characterized. These included intercalary arthroconidia, several types of septate conidia that are formed from other conidia, pedunculate conidia, and terminal hyphal conidia. In addition, the ultrastructure of the supporting pedestal of the pedunculate conidium was found to be separated from the mother conidium by a septum in some instances, and at other times it was not. Mención de responsabilidad : William A. Samsonoff, M. E. Salazar, M. L. McKee, A. Restrepo, L. E. Cano & M. R. Edwards Referencia : Mycopathologia. 1991 Apr;114(1):9-15. DOI (Digital Object Identifier) : 10.1007/BF00436685 PMID : 1857400 En línea : https://link.springer.com/article/10.1007/BF00436685 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4361 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000861 AC-1991-003 Archivo digital Producción Científica Artículos científicos Disponible Treatment of paracoccidioidomycosis with itraconazole / María Soledad Naranjo Mesa ; Mónica Rosa Trujillo Honeysberg ; María Isabel Múnera Jaramillo ; P. Restrepo ; Iván Gómez ; Ángela Restrepo Moreno
Título : Treatment of paracoccidioidomycosis with itraconazole Tipo de documento : documento electrónico Autores : María Soledad Naranjo Mesa, ; Mónica Rosa Trujillo Honeysberg, ; María Isabel Múnera Jaramillo, ; P. Restrepo, ; Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1990 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Forty-seven patients with active paracoccidioidomycosis were treated with itraconazole. The majority of the patients (45) had the chronic adult form of the disease while the remaining exhibited the juvenile form. All of the patients received itraconazole, 100 mg day-1, with the exception of two for whom the clinical condition necessitated a larger dose. The mean duration of therapy was 6 months, with a range of 3–24 months. Clinically, the skin and mucous membrane lesions as well as abdominal pain, auscultatory alterations and dysphonia improved markedly during treatment with a concomitant increase in weight. However, other symptoms (cough, expectoration and dyspnoea) persisted as sequelae in some cases. As expected, adrenal insufficiency also persisted. The radiological lesions showed a gradual decrease of both scattered and confluent infiltrates, present in 67% of patients before, and in 13% at the end of treatment. On the other hand, fibrosis became more evident at the termination of therapy, increasing from 62% of patients at the beginning of therapy to 81% at the end. The mycological tests (direct examination and cultures) became negative during the first month of treatment in 42 patients (87%). A decline in specific antibody titres was observed in 72% of patients by the end of treatment. Evaluation of therapy by means of a scoring system indicated complete resolution of the disease in one patient (2%), marked improvement in 42 (89%) and minor improvement in four (8·5%); none of the patients showed a deterioration of their disease during therapy. Of fifteen patients who were followed up for 12 months post-therapy none showed clinical relapse during this period. The results of this study confirm the efficacy of itraconazole in the treatment of paracoccidioidomycosis. Mención de responsabilidad : M.S. Naranjo, M. Trujillo, M.I. Munera, P. Restrepo, I. Gomez, A. Restrepo Referencia : J Med Vet Mycol. 1990;28(1):67-76 DOI (Digital Object Identifier) : 10.1080/02681219080000091 PMID : 2163442 En línea : https://academic.oup.com/mmy/article-abstract/28/1/67/894889 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4356 Treatment of paracoccidioidomycosis with itraconazole [documento electrónico] / María Soledad Naranjo Mesa, ; Mónica Rosa Trujillo Honeysberg, ; María Isabel Múnera Jaramillo, ; P. Restrepo, ; Iván Gómez, ; Ángela Restrepo Moreno, . - 1990.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : Forty-seven patients with active paracoccidioidomycosis were treated with itraconazole. The majority of the patients (45) had the chronic adult form of the disease while the remaining exhibited the juvenile form. All of the patients received itraconazole, 100 mg day-1, with the exception of two for whom the clinical condition necessitated a larger dose. The mean duration of therapy was 6 months, with a range of 3–24 months. Clinically, the skin and mucous membrane lesions as well as abdominal pain, auscultatory alterations and dysphonia improved markedly during treatment with a concomitant increase in weight. However, other symptoms (cough, expectoration and dyspnoea) persisted as sequelae in some cases. As expected, adrenal insufficiency also persisted. The radiological lesions showed a gradual decrease of both scattered and confluent infiltrates, present in 67% of patients before, and in 13% at the end of treatment. On the other hand, fibrosis became more evident at the termination of therapy, increasing from 62% of patients at the beginning of therapy to 81% at the end. The mycological tests (direct examination and cultures) became negative during the first month of treatment in 42 patients (87%). A decline in specific antibody titres was observed in 72% of patients by the end of treatment. Evaluation of therapy by means of a scoring system indicated complete resolution of the disease in one patient (2%), marked improvement in 42 (89%) and minor improvement in four (8·5%); none of the patients showed a deterioration of their disease during therapy. Of fifteen patients who were followed up for 12 months post-therapy none showed clinical relapse during this period. The results of this study confirm the efficacy of itraconazole in the treatment of paracoccidioidomycosis. Mención de responsabilidad : M.S. Naranjo, M. Trujillo, M.I. Munera, P. Restrepo, I. Gomez, A. Restrepo Referencia : J Med Vet Mycol. 1990;28(1):67-76 DOI (Digital Object Identifier) : 10.1080/02681219080000091 PMID : 2163442 En línea : https://academic.oup.com/mmy/article-abstract/28/1/67/894889 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4356 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000856 AC-1990-001 Archivo digital Producción Científica Artículos científicos Disponible Virulence of Paracoccidioides brasiliensis: The influence of in vitro passage and storage / Ángela Restrepo MorenoPermalinkSeguimiento post-terapia de pacientes con paracoccidioidomicosis tratados con itraconazol / María Isabel Múnera Jaramillo ; María Soledad Naranjo Mesa ; Iván Gómez ; Ángela Restrepo MorenoPermalinkVirulence of a variant of Paracoccidioides brasiliensis that exists in the yeast form at room temperature / L. A. Villar ; Ángela Restrepo MorenoPermalinkEl caso de infecciosas: Itraconazol como terapia alternativa a los yoduros en el tratamiento de la esporotricosis / María Teresa Ochoa ; Iván Gómez ; Ángela Restrepo MorenoPermalinkGrowth and production of iron chelants by Paracoccidioides brasiliensis mycelial and yeast forms / R. Arango ; Ángela Restrepo MorenoPermalinkInhibition by estrogens of conidium-to-yeast conversion in the fungus Paracoccidioides brasiliensis / Maria E. Salazar ; Ángela Restrepo MorenoPermalinkMorphological study of a variant of Paracoccidioides brasiliensis that exists in the yeast form at room temperature / L. A. Villar ; Maria E. Salazar ; Ángela Restrepo MorenoPermalinkTreatment of chromoblastomycosis with itraconazole / Ángela Restrepo Moreno ; Aurelio González ; Iván Gómez ; Myrtha Arango Arteaga ; Catalina de Bedout GómezPermalinkNuclear staining of Paracoccidioides brasiliensis conidia / Juan Guillermo McEwen Ochoa ; Blanca I. Restrepo ; Maria E. Salazar ; Ángela Restrepo MorenoPermalinkPredictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis / Luz Elena Cano Restrepo ; Ángela Restrepo MorenoPermalink