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Autor Ángela Restrepo Moreno |
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Adrenal function in paracoccidioidomycosis: A prospective study in patients before and after ketoconazole therapy / Iván Gómez ; Ángela Restrepo Moreno
Título : Adrenal function in paracoccidioidomycosis: A prospective study in patients before and after ketoconazole therapy Tipo de documento : documento electrónico Autores : Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1986 Títulos uniformes : Infection Idioma : Inglés (eng) Resumen : The adrenal gland functional reserve was studied in a group of 22 patients with active paracoccidioidomycosis before therapy and in 18 of the same patients after termination of six months of ketoconazole treatment. 22 control subjects were also tested. Serum cortisol was measured before and after i.v. infusion of 250 µg of corticotropin given over a period of two hours. Basal cortisol levels were subnormal in only one patient before treatment and in four of 18 patients after therapy. Overt Addison's disease was found in 14% of the patients before treatment. However, corticotropin stimulation revealed diminished adrenal reserve in 23% of patients before, and in 44% of the patients after treatment. Although decreased adrenal cortex function after therapy may be influenced by ketoconazole, more studies are needed to determine the role of this agent after prolonged use. The high frequency of subclinical adrenal failure in paracoccidioidomycosis should alert clinicians in charge of such patients, should they face physiological stress. Mención de responsabilidad : A. Abad M.D., P. Velez M. T., I. Gomez M.D. & Angela Restrepo Ph. D. Referencia : Infection. Jan-Feb 1986;14(1):22-6. DOI (Digital Object Identifier) : 10.1007/BF01644805 PMID : 3007365 En línea : https://link.springer.com/article/10.1007%2FBF01644805 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4341 Adrenal function in paracoccidioidomycosis: A prospective study in patients before and after ketoconazole therapy [documento electrónico] / Iván Gómez, ; Ángela Restrepo Moreno, . - 1986.
Obra : Infection
Idioma : Inglés (eng)
Resumen : The adrenal gland functional reserve was studied in a group of 22 patients with active paracoccidioidomycosis before therapy and in 18 of the same patients after termination of six months of ketoconazole treatment. 22 control subjects were also tested. Serum cortisol was measured before and after i.v. infusion of 250 µg of corticotropin given over a period of two hours. Basal cortisol levels were subnormal in only one patient before treatment and in four of 18 patients after therapy. Overt Addison's disease was found in 14% of the patients before treatment. However, corticotropin stimulation revealed diminished adrenal reserve in 23% of patients before, and in 44% of the patients after treatment. Although decreased adrenal cortex function after therapy may be influenced by ketoconazole, more studies are needed to determine the role of this agent after prolonged use. The high frequency of subclinical adrenal failure in paracoccidioidomycosis should alert clinicians in charge of such patients, should they face physiological stress. Mención de responsabilidad : A. Abad M.D., P. Velez M. T., I. Gomez M.D. & Angela Restrepo Ph. D. Referencia : Infection. Jan-Feb 1986;14(1):22-6. DOI (Digital Object Identifier) : 10.1007/BF01644805 PMID : 3007365 En línea : https://link.springer.com/article/10.1007%2FBF01644805 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4341 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000842 AC-1986-008 Archivo digital Producción Científica Artículos científicos Disponible An evaluation of the enzyme-linked immunoabsorbent assay (ELISA) for quantitation of antibodies to paracoccidioides brasiliensis / Luz Elena Cano Restrepo ; Ángela Restrepo Moreno
Título : An evaluation of the enzyme-linked immunoabsorbent assay (ELISA) for quantitation of antibodies to paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, Fecha de publicación : 1986 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The ELISA procedure was adapted for quantitation of antibodies against Paracoccidioides brasiliensis. Using a yeast cytoplasmic antigen and sera from patients with proven paracoccidioidomycosis, we found that 66% of sera reacted at titers ≥1:128. Titers of this magnitude were obtained only for 4–5% of sera from healthy blood donors, tuberculosis patients and patients with other systemic mycoses. The exception was sera from patients with histoplasmosis (36% had titers ≥1:128). Follow-up of 10 paracoccidioidomycosis patients during the course of therapy indicated a gradual decrease in antibody titers. Because of the technical advantages of the ELISA procedure in comparison with the standard complement fixation test, the ELISA test has potential utility for the quantitative determination of antibodies in patients with paracoccidioidomycosis. Mención de responsabilidad : Luz E. Cano, Elmer Brummer, David A. Stevens, Angela Restrepo Referencia : J Med Vet Mycol. 1986 Dec;24(6):467-75. DOI (Digital Object Identifier) : 10.1080/02681218680000741 PMID : 3572681 En línea : https://academic.oup.com/mmy/article-abstract/24/6/467/875557 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4342 An evaluation of the enzyme-linked immunoabsorbent assay (ELISA) for quantitation of antibodies to paracoccidioides brasiliensis [documento electrónico] / Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, . - 1986.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : The ELISA procedure was adapted for quantitation of antibodies against Paracoccidioides brasiliensis. Using a yeast cytoplasmic antigen and sera from patients with proven paracoccidioidomycosis, we found that 66% of sera reacted at titers ≥1:128. Titers of this magnitude were obtained only for 4–5% of sera from healthy blood donors, tuberculosis patients and patients with other systemic mycoses. The exception was sera from patients with histoplasmosis (36% had titers ≥1:128). Follow-up of 10 paracoccidioidomycosis patients during the course of therapy indicated a gradual decrease in antibody titers. Because of the technical advantages of the ELISA procedure in comparison with the standard complement fixation test, the ELISA test has potential utility for the quantitative determination of antibodies in patients with paracoccidioidomycosis. Mención de responsabilidad : Luz E. Cano, Elmer Brummer, David A. Stevens, Angela Restrepo Referencia : J Med Vet Mycol. 1986 Dec;24(6):467-75. DOI (Digital Object Identifier) : 10.1080/02681218680000741 PMID : 3572681 En línea : https://academic.oup.com/mmy/article-abstract/24/6/467/875557 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4342 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000843 AC-1986-009 Archivo digital Producción Científica Artículos científicos Disponible Itraconazole therapy in lymphangitic and cutaneous sporotrichosis / Ángela Restrepo Moreno ; Jaime Robledo ; Iván Gómez ; Ángela María Tabares Velásquez ; Regina Gutiérrez
Título : Itraconazole therapy in lymphangitic and cutaneous sporotrichosis Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Jaime Robledo, ; Iván Gómez, ; Ángela María Tabares Velásquez, ; Regina Gutiérrez, Fecha de publicación : 1986 Títulos uniformes : JAMA Dermatology Idioma : Inglés (eng) Resumen : Itraconazole, a new orally absorbable azole derivative, was used for the treatment of 17 patients with cutaneous and lymphangitic sporotrichosis. The drug, administered at a dose of 100 mg/day, proved to be effective in all cases. Lesions disappeared and cultures became negative after 90 to 180 days of therapy. There were no major side effects. Posttherapy evaluations, done in 14 of 17 cases for an average of 115 days, revealed no relapses. Objective evaluation of the treatment by means of a scoring system indicated complete resolution of the pretherapy abnormalities at varying periods; thus, 35.3% (six of 17) of the patients had recovered by 90 days, 45.4% (five of 11) by 120 days, and 83.3% (five of six) by 150 days of therapy. Consequently, therapy with itraconazole is an adequate alternative to iodide treatment in sporotrichosis. Mención de responsabilidad : Angela Restrepo, PhD; Jaime Robledo, MD; Iván Gómez,MD; Angela Maria Tabares, MT; Regina Gutiérrez,MT Referencia : Arch Dermatol. 1986 Apr;122(4):413-7. DOI (Digital Object Identifier) : 10.1001/archderm.1986.01660160069021 PMID : 3006602 En línea : https://jamanetwork.com/journals/jamadermatology/article-abstract/547067 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4340 Itraconazole therapy in lymphangitic and cutaneous sporotrichosis [documento electrónico] / Ángela Restrepo Moreno, ; Jaime Robledo, ; Iván Gómez, ; Ángela María Tabares Velásquez, ; Regina Gutiérrez, . - 1986.
Obra : JAMA Dermatology
Idioma : Inglés (eng)
Resumen : Itraconazole, a new orally absorbable azole derivative, was used for the treatment of 17 patients with cutaneous and lymphangitic sporotrichosis. The drug, administered at a dose of 100 mg/day, proved to be effective in all cases. Lesions disappeared and cultures became negative after 90 to 180 days of therapy. There were no major side effects. Posttherapy evaluations, done in 14 of 17 cases for an average of 115 days, revealed no relapses. Objective evaluation of the treatment by means of a scoring system indicated complete resolution of the pretherapy abnormalities at varying periods; thus, 35.3% (six of 17) of the patients had recovered by 90 days, 45.4% (five of 11) by 120 days, and 83.3% (five of six) by 150 days of therapy. Consequently, therapy with itraconazole is an adequate alternative to iodide treatment in sporotrichosis. Mención de responsabilidad : Angela Restrepo, PhD; Jaime Robledo, MD; Iván Gómez,MD; Angela Maria Tabares, MT; Regina Gutiérrez,MT Referencia : Arch Dermatol. 1986 Apr;122(4):413-7. DOI (Digital Object Identifier) : 10.1001/archderm.1986.01660160069021 PMID : 3006602 En línea : https://jamanetwork.com/journals/jamadermatology/article-abstract/547067 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4340 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000840 AC-1986-006 Archivo digital Producción Científica Artículos científicos Disponible Morphological development of the conidia produced by paracoccidioides brasiliensis mycelial form / Blanca I. Restrepo ; Juan Guillermo McEwen Ochoa ; Maria E. Salazar ; Ángela Restrepo Moreno
Título : Morphological development of the conidia produced by paracoccidioides brasiliensis mycelial form Tipo de documento : documento electrónico Autores : Blanca I. Restrepo, ; Juan Guillermo McEwen Ochoa, ; Maria E. Salazar, ; Ángela Restrepo Moreno, Fecha de publicación : 1986 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : P. brasiliensis conidia were studied for their ability to grow as yeasts or as molds according to temperature. Using a microculture system we found that such conidia shared the ability of the parent mycelium to transform directly into multiple-budding yeast cells at 36°C or to produce germ tubes and branching mycelia if kept at 22°C. Mención de responsabilidad : Blanca I. Restrepo, Juan G. McEwen, Maria E. Salazar, Angela Restrepo Referencia : J Med Vet Mycol. 1986 Aug;24(4):337-9. DOI (Digital Object Identifier) : 10.1080/02681218680000491 PMID : 3746586 En línea : https://academic.oup.com/mmy/article-abstract/24/4/337/921937 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4339 Morphological development of the conidia produced by paracoccidioides brasiliensis mycelial form [documento electrónico] / Blanca I. Restrepo, ; Juan Guillermo McEwen Ochoa, ; Maria E. Salazar, ; Ángela Restrepo Moreno, . - 1986.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : P. brasiliensis conidia were studied for their ability to grow as yeasts or as molds according to temperature. Using a microculture system we found that such conidia shared the ability of the parent mycelium to transform directly into multiple-budding yeast cells at 36°C or to produce germ tubes and branching mycelia if kept at 22°C. Mención de responsabilidad : Blanca I. Restrepo, Juan G. McEwen, Maria E. Salazar, Angela Restrepo Referencia : J Med Vet Mycol. 1986 Aug;24(4):337-9. DOI (Digital Object Identifier) : 10.1080/02681218680000491 PMID : 3746586 En línea : https://academic.oup.com/mmy/article-abstract/24/4/337/921937 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4339 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000841 AC-1986-007 Archivo digital Producción Científica Artículos científicos Disponible Pathogenesis of paracoccidioidomycosis: A histopathological study of the experimental murine infection / Víctor Bedoya M. ; Juan Guillermo McEwen Ochoa ; Ángela María Tabares Velásquez ; Fabio Uribe Jaramillo ; Ángela Restrepo Moreno
Título : Pathogenesis of paracoccidioidomycosis: A histopathological study of the experimental murine infection Tipo de documento : documento electrónico Autores : Víctor Bedoya M., ; Juan Guillermo McEwen Ochoa, ; Ángela María Tabares Velásquez, ; Fabio Uribe Jaramillo, ; Ángela Restrepo Moreno, Fecha de publicación : 1986 Títulos uniformes : Mycopathologia Idioma : Inglés (eng) Resumen : The pathogenesis of primary pulmonary P. brasiliensis infection, the systemic dissemination which followed, and the histopathology of the main organs involved was studied in a murine model of chronic paracoccidioidomycosis. Adult male BALB/C mice, were challenged intranasally with 26×10−6 viable P. brasiliensis yeast cells. We inoculated 86 animals which were sacrificed from 0 h to 20 weeks. As controls, 11 mice were instilled with saline solution, and 48 with 26×10−6 heat-killed. P. brasiliensis yeast cells. None of the animals receiving saline, exhibited pathologic alterations; 11.6% of those inoculated with the heatkilled cells, revealed mild, transitory acinopulmonary neutrophilic infiltrates. The animals infected with viable cells, developed a systemic process affecting mainly the lungs (46.5%), liver (18.6%), lymphnodes (18.6%), and spleen (3.5%). In this group of animals, lung lesions were detected regularly at all time periods from 3 h to 20 weeks. A multiple bronchoneumonic process was initially observed at 6 h, reached its maximum intensity around the third day, subsided thereafter but did not disappear and reactivated after the fifth week to become stationary until the end of experiments. Dissemination to other organs occurred early, and apparently by the hematogenous route. Initially the inflammatory cell infiltrate was mainly neutrophilic. With time, these cells were gradually replaced by lymphocytes, histiocytes and plasmocytes. Granuloma configuration of the cell infiltrate was distinctly seen around the fifth week, with multinucleated giant cells appearing at the ninth week. Hiliary lymphnode involvement was rare (7%) and primary lung lesions, as seen in tuberculosis and histoplasmosis, were not observed. Mención de responsabilidad : Víctor Bedoya, Juan G. McEwen, Angela M. Tabares, Fabio Uribe Jaramillo & Angela Restrepo Referencia : Mycopathologia. 1986 Jun;94(3):133-44. DOI (Digital Object Identifier) : 10.1007/BF00454591 PMID : 3762654 En línea : https://link.springer.com/article/10.1007%2FBF00454591 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4338 Pathogenesis of paracoccidioidomycosis: A histopathological study of the experimental murine infection [documento electrónico] / Víctor Bedoya M., ; Juan Guillermo McEwen Ochoa, ; Ángela María Tabares Velásquez, ; Fabio Uribe Jaramillo, ; Ángela Restrepo Moreno, . - 1986.
Obra : Mycopathologia
Idioma : Inglés (eng)
Resumen : The pathogenesis of primary pulmonary P. brasiliensis infection, the systemic dissemination which followed, and the histopathology of the main organs involved was studied in a murine model of chronic paracoccidioidomycosis. Adult male BALB/C mice, were challenged intranasally with 26×10−6 viable P. brasiliensis yeast cells. We inoculated 86 animals which were sacrificed from 0 h to 20 weeks. As controls, 11 mice were instilled with saline solution, and 48 with 26×10−6 heat-killed. P. brasiliensis yeast cells. None of the animals receiving saline, exhibited pathologic alterations; 11.6% of those inoculated with the heatkilled cells, revealed mild, transitory acinopulmonary neutrophilic infiltrates. The animals infected with viable cells, developed a systemic process affecting mainly the lungs (46.5%), liver (18.6%), lymphnodes (18.6%), and spleen (3.5%). In this group of animals, lung lesions were detected regularly at all time periods from 3 h to 20 weeks. A multiple bronchoneumonic process was initially observed at 6 h, reached its maximum intensity around the third day, subsided thereafter but did not disappear and reactivated after the fifth week to become stationary until the end of experiments. Dissemination to other organs occurred early, and apparently by the hematogenous route. Initially the inflammatory cell infiltrate was mainly neutrophilic. With time, these cells were gradually replaced by lymphocytes, histiocytes and plasmocytes. Granuloma configuration of the cell infiltrate was distinctly seen around the fifth week, with multinucleated giant cells appearing at the ninth week. Hiliary lymphnode involvement was rare (7%) and primary lung lesions, as seen in tuberculosis and histoplasmosis, were not observed. Mención de responsabilidad : Víctor Bedoya, Juan G. McEwen, Angela M. Tabares, Fabio Uribe Jaramillo & Angela Restrepo Referencia : Mycopathologia. 1986 Jun;94(3):133-44. DOI (Digital Object Identifier) : 10.1007/BF00454591 PMID : 3762654 En línea : https://link.springer.com/article/10.1007%2FBF00454591 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4338 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000839 AC-1986-005 Archivo digital Producción Científica Artículos científicos Disponible Water as a substrate for the development of Paracoccidiodes brasiliensis mycelial form / Catalina de Bedout Gómez ; Luz Elena Cano Restrepo ; Ángela María Tabares Velásquez ; Ángela Restrepo MorenoPermalinkPermalinkLack of antibody induction by histolyn-CYL® a new skin-testing reagent for histoplasmosis / Ángela Restrepo MorenoPermalinkThe radiological appearances of pulmonary paracoccidioidomycosis and the effects of ketoconazole therapy / Iván Gómez ; Ángela Restrepo MorenoPermalinkA yeast-derived antigen from paracoccidioides brasiliensis useful for serologic testing / Ángela Restrepo Moreno ; Luz Elena Cano Restrepo ; María Teresa OchoaPermalinkChronic murine paracoccidioidomycosis: Effect of ketoconazole on clearance of paracoccidioides brasiliensis and immune response / Guillermo L. Hoyos ; Juan Guillermo McEwen Ochoa ; Ángela Restrepo MorenoPermalinkEffect of temperature on the mycelium to yeast transformation of paracoccidioides brasiliensis / María Mercedes Patiño ; Luis C. Burgos ; Ángela Restrepo MorenoPermalinkEstrogens inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: Implications for resistance of females to Paracoccidioidomycosis / Ángela Restrepo Moreno ; Maria E. Salazar ; Luz Elena Cano RestrepoPermalinkIn vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents / Ángela Restrepo Moreno ; Catalina de Bedout Gómez ; Ángela María Tabares VelásquezPermalinkBlood groups and HLA antigens in paracoccidioidomycosis / Fabiola Montoya de Restrepo ; Marcos Restrepo ; Ángela Restrepo MorenoPermalink