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Autor Ángela María Tabares Velásquez |
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Clasificado(s) por (Año de edición descendente) Refinar búsquedaActivity of two different triazoles in a murine model of paracoccidioidomycosis / Susana Restrepo ; Ángela María Tabares Velásquez ; Ángela Restrepo Moreno
Título : Activity of two different triazoles in a murine model of paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Activity of two different triazoles in a murine model of paracoccidioidomycosis [documento electrónico] / Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, . - 1992.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000864 AC-1992-003 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1992-003.pdfAdobe Acrobat PDF
Título : Itraconazole therapy in lymphangitic and cutaneous sporotrichosis Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Jaime Robledo, ; Iván Gómez, ; Ángela María Tabares Velásquez, ; Regina Gutiérrez, Fecha de publicación : 1986 Títulos uniformes : JAMA Dermatology Idioma : Inglés (eng) Resumen : Itraconazole, a new orally absorbable azole derivative, was used for the treatment of 17 patients with cutaneous and lymphangitic sporotrichosis. The drug, administered at a dose of 100 mg/day, proved to be effective in all cases. Lesions disappeared and cultures became negative after 90 to 180 days of therapy. There were no major side effects. Posttherapy evaluations, done in 14 of 17 cases for an average of 115 days, revealed no relapses. Objective evaluation of the treatment by means of a scoring system indicated complete resolution of the pretherapy abnormalities at varying periods; thus, 35.3% (six of 17) of the patients had recovered by 90 days, 45.4% (five of 11) by 120 days, and 83.3% (five of six) by 150 days of therapy. Consequently, therapy with itraconazole is an adequate alternative to iodide treatment in sporotrichosis. Mención de responsabilidad : Angela Restrepo, PhD; Jaime Robledo, MD; Iván Gómez,MD; Angela Maria Tabares, MT; Regina Gutiérrez,MT Referencia : Arch Dermatol. 1986 Apr;122(4):413-7. DOI (Digital Object Identifier) : 10.1001/archderm.1986.01660160069021 PMID : 3006602 En línea : https://jamanetwork.com/journals/jamadermatology/article-abstract/547067 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4340 Itraconazole therapy in lymphangitic and cutaneous sporotrichosis [documento electrónico] / Ángela Restrepo Moreno, ; Jaime Robledo, ; Iván Gómez, ; Ángela María Tabares Velásquez, ; Regina Gutiérrez, . - 1986.
Obra : JAMA Dermatology
Idioma : Inglés (eng)
Resumen : Itraconazole, a new orally absorbable azole derivative, was used for the treatment of 17 patients with cutaneous and lymphangitic sporotrichosis. The drug, administered at a dose of 100 mg/day, proved to be effective in all cases. Lesions disappeared and cultures became negative after 90 to 180 days of therapy. There were no major side effects. Posttherapy evaluations, done in 14 of 17 cases for an average of 115 days, revealed no relapses. Objective evaluation of the treatment by means of a scoring system indicated complete resolution of the pretherapy abnormalities at varying periods; thus, 35.3% (six of 17) of the patients had recovered by 90 days, 45.4% (five of 11) by 120 days, and 83.3% (five of six) by 150 days of therapy. Consequently, therapy with itraconazole is an adequate alternative to iodide treatment in sporotrichosis. Mención de responsabilidad : Angela Restrepo, PhD; Jaime Robledo, MD; Iván Gómez,MD; Angela Maria Tabares, MT; Regina Gutiérrez,MT Referencia : Arch Dermatol. 1986 Apr;122(4):413-7. DOI (Digital Object Identifier) : 10.1001/archderm.1986.01660160069021 PMID : 3006602 En línea : https://jamanetwork.com/journals/jamadermatology/article-abstract/547067 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4340 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000840 AC-1986-006 Archivo digital Producción Científica Artículos científicos Disponible
Título : Pathogenesis of paracoccidioidomycosis: A histopathological study of the experimental murine infection Tipo de documento : documento electrónico Autores : Víctor Bedoya M., ; Juan Guillermo McEwen Ochoa, ; Ángela María Tabares Velásquez, ; Fabio Uribe Jaramillo, ; Ángela Restrepo Moreno, Fecha de publicación : 1986 Títulos uniformes : Mycopathologia Idioma : Inglés (eng) Resumen : The pathogenesis of primary pulmonary P. brasiliensis infection, the systemic dissemination which followed, and the histopathology of the main organs involved was studied in a murine model of chronic paracoccidioidomycosis. Adult male BALB/C mice, were challenged intranasally with 26×10−6 viable P. brasiliensis yeast cells. We inoculated 86 animals which were sacrificed from 0 h to 20 weeks. As controls, 11 mice were instilled with saline solution, and 48 with 26×10−6 heat-killed. P. brasiliensis yeast cells. None of the animals receiving saline, exhibited pathologic alterations; 11.6% of those inoculated with the heatkilled cells, revealed mild, transitory acinopulmonary neutrophilic infiltrates. The animals infected with viable cells, developed a systemic process affecting mainly the lungs (46.5%), liver (18.6%), lymphnodes (18.6%), and spleen (3.5%). In this group of animals, lung lesions were detected regularly at all time periods from 3 h to 20 weeks. A multiple bronchoneumonic process was initially observed at 6 h, reached its maximum intensity around the third day, subsided thereafter but did not disappear and reactivated after the fifth week to become stationary until the end of experiments. Dissemination to other organs occurred early, and apparently by the hematogenous route. Initially the inflammatory cell infiltrate was mainly neutrophilic. With time, these cells were gradually replaced by lymphocytes, histiocytes and plasmocytes. Granuloma configuration of the cell infiltrate was distinctly seen around the fifth week, with multinucleated giant cells appearing at the ninth week. Hiliary lymphnode involvement was rare (7%) and primary lung lesions, as seen in tuberculosis and histoplasmosis, were not observed. Mención de responsabilidad : Víctor Bedoya, Juan G. McEwen, Angela M. Tabares, Fabio Uribe Jaramillo & Angela Restrepo Referencia : Mycopathologia. 1986 Jun;94(3):133-44. DOI (Digital Object Identifier) : 10.1007/BF00454591 PMID : 3762654 En línea : https://link.springer.com/article/10.1007%2FBF00454591 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4338 Pathogenesis of paracoccidioidomycosis: A histopathological study of the experimental murine infection [documento electrónico] / Víctor Bedoya M., ; Juan Guillermo McEwen Ochoa, ; Ángela María Tabares Velásquez, ; Fabio Uribe Jaramillo, ; Ángela Restrepo Moreno, . - 1986.
Obra : Mycopathologia
Idioma : Inglés (eng)
Resumen : The pathogenesis of primary pulmonary P. brasiliensis infection, the systemic dissemination which followed, and the histopathology of the main organs involved was studied in a murine model of chronic paracoccidioidomycosis. Adult male BALB/C mice, were challenged intranasally with 26×10−6 viable P. brasiliensis yeast cells. We inoculated 86 animals which were sacrificed from 0 h to 20 weeks. As controls, 11 mice were instilled with saline solution, and 48 with 26×10−6 heat-killed. P. brasiliensis yeast cells. None of the animals receiving saline, exhibited pathologic alterations; 11.6% of those inoculated with the heatkilled cells, revealed mild, transitory acinopulmonary neutrophilic infiltrates. The animals infected with viable cells, developed a systemic process affecting mainly the lungs (46.5%), liver (18.6%), lymphnodes (18.6%), and spleen (3.5%). In this group of animals, lung lesions were detected regularly at all time periods from 3 h to 20 weeks. A multiple bronchoneumonic process was initially observed at 6 h, reached its maximum intensity around the third day, subsided thereafter but did not disappear and reactivated after the fifth week to become stationary until the end of experiments. Dissemination to other organs occurred early, and apparently by the hematogenous route. Initially the inflammatory cell infiltrate was mainly neutrophilic. With time, these cells were gradually replaced by lymphocytes, histiocytes and plasmocytes. Granuloma configuration of the cell infiltrate was distinctly seen around the fifth week, with multinucleated giant cells appearing at the ninth week. Hiliary lymphnode involvement was rare (7%) and primary lung lesions, as seen in tuberculosis and histoplasmosis, were not observed. Mención de responsabilidad : Víctor Bedoya, Juan G. McEwen, Angela M. Tabares, Fabio Uribe Jaramillo & Angela Restrepo Referencia : Mycopathologia. 1986 Jun;94(3):133-44. DOI (Digital Object Identifier) : 10.1007/BF00454591 PMID : 3762654 En línea : https://link.springer.com/article/10.1007%2FBF00454591 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4338 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000839 AC-1986-005 Archivo digital Producción Científica Artículos científicos Disponible
Título : Water as a substrate for the development of Paracoccidiodes brasiliensis mycelial form Tipo de documento : documento electrónico Autores : Catalina de Bedout Gómez, ; Luz Elena Cano Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, Fecha de publicación : 1986 Títulos uniformes : Mycopathologia Idioma : Inglés (eng) Resumen : Two isolates of P. brasiliensis in the mycelial form were studied for their capacity to survive and grow in sterile distilled water (SDW). Inoculum for the experiments consisted of a spectrophotometrically-standardized suspension of washed and homogenized mycelial fragments; these had been obtained from 2-week old cultures grown in a synthetic medium (SM). Series of tubes with SDW and SM were incubated with the above suspension and kept stationary for 6 months at either 4 °C or room temperature (RT). Growth was measured by dry weight (DW) and turbidity (OD) determinations; additionally, CFU and ultrastructural appearance by transmission electron microscope (TEM) were assesed for one of the isolates. In general, cultures in SM at RT, grew exponentially after 2 weeks, becoming stationary for 7 weeks and then, declining abruptly. In SDW, fungal development was slow for 5 months when an increase in mass was recorded. When incubated at 4° C, both SDW and SM cultures required longer time to develop but mass also increased. Morphologically, mycelial elements in SDW at RT exhibited increased lipid vacuoles and glycogen deposits but were otherwise normal up to 6 weeks when they presented the inter-hyphae-hyphae phenomenum. In SDW P. brasiliensis appears to utilize debris from its degenerated fungal partners to continue growing. Mención de responsabilidad : Catalina de Bedout, Luz E. Cano, Angela M. Tabares, M. Van de Ven & Angela Restrepo Referencia : Mycopathologia. 1986 Nov;96(2):123-30. DOI (Digital Object Identifier) : 10.1007/BF00436671 PMID : 3796714 En línea : https://link.springer.com/article/10.1007%2FBF00436671 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4337 Water as a substrate for the development of Paracoccidiodes brasiliensis mycelial form [documento electrónico] / Catalina de Bedout Gómez, ; Luz Elena Cano Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, . - 1986.
Obra : Mycopathologia
Idioma : Inglés (eng)
Resumen : Two isolates of P. brasiliensis in the mycelial form were studied for their capacity to survive and grow in sterile distilled water (SDW). Inoculum for the experiments consisted of a spectrophotometrically-standardized suspension of washed and homogenized mycelial fragments; these had been obtained from 2-week old cultures grown in a synthetic medium (SM). Series of tubes with SDW and SM were incubated with the above suspension and kept stationary for 6 months at either 4 °C or room temperature (RT). Growth was measured by dry weight (DW) and turbidity (OD) determinations; additionally, CFU and ultrastructural appearance by transmission electron microscope (TEM) were assesed for one of the isolates. In general, cultures in SM at RT, grew exponentially after 2 weeks, becoming stationary for 7 weeks and then, declining abruptly. In SDW, fungal development was slow for 5 months when an increase in mass was recorded. When incubated at 4° C, both SDW and SM cultures required longer time to develop but mass also increased. Morphologically, mycelial elements in SDW at RT exhibited increased lipid vacuoles and glycogen deposits but were otherwise normal up to 6 weeks when they presented the inter-hyphae-hyphae phenomenum. In SDW P. brasiliensis appears to utilize debris from its degenerated fungal partners to continue growing. Mención de responsabilidad : Catalina de Bedout, Luz E. Cano, Angela M. Tabares, M. Van de Ven & Angela Restrepo Referencia : Mycopathologia. 1986 Nov;96(2):123-30. DOI (Digital Object Identifier) : 10.1007/BF00436671 PMID : 3796714 En línea : https://link.springer.com/article/10.1007%2FBF00436671 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4337 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000838 AC-1986-004 Archivo digital Producción Científica Artículos científicos Disponible
Título : In vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Catalina de Bedout Gómez, ; Ángela María Tabares Velásquez, Fecha de publicación : 1984 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Resumen : A study was conducted to determine the susceptibility of P. brasiliensis yeast form to amphotericin B (A), ketoconazole (K), 5-fluorocytosine (5-FC) and rifampin (R). The three isolates tested produced minimal inhibitory concentrations (MICs) (mcg/ml) in the following range: A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 and R: 40-80. The minimal fungicidal concentrations (MFC) were several times higher than the corresponding MICs. Precise MFC for 5-FC were not obtained (> 500 mcg/ml). Combination of K plus A proved synergic, with the fractional inhibitory concentration (FIC) indices revealing synergy when the drugs were combined at the 1 to 1 and 1 to 5 MIC ratios. R (40 mcg/ml) appeared to antagonize K. These results indicate promise for the combined use of K plus A as a therapeutical regimen. Mención de responsabilidad : RESTREPO, Angela and TABARES, Catalina de Bedout and Angela M. Referencia : Rev Inst Med Trop Sao Paulo. Nov-Dec 1984;26(6):322-8. DOI (Digital Object Identifier) : 10.1590/S0036-46651984000600006 PMID : 6100138 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651984000600006 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4329 In vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents [documento electrónico] / Ángela Restrepo Moreno, ; Catalina de Bedout Gómez, ; Ángela María Tabares Velásquez, . - 1984.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Resumen : A study was conducted to determine the susceptibility of P. brasiliensis yeast form to amphotericin B (A), ketoconazole (K), 5-fluorocytosine (5-FC) and rifampin (R). The three isolates tested produced minimal inhibitory concentrations (MICs) (mcg/ml) in the following range: A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 and R: 40-80. The minimal fungicidal concentrations (MFC) were several times higher than the corresponding MICs. Precise MFC for 5-FC were not obtained (> 500 mcg/ml). Combination of K plus A proved synergic, with the fractional inhibitory concentration (FIC) indices revealing synergy when the drugs were combined at the 1 to 1 and 1 to 5 MIC ratios. R (40 mcg/ml) appeared to antagonize K. These results indicate promise for the combined use of K plus A as a therapeutical regimen. Mención de responsabilidad : RESTREPO, Angela and TABARES, Catalina de Bedout and Angela M. Referencia : Rev Inst Med Trop Sao Paulo. Nov-Dec 1984;26(6):322-8. DOI (Digital Object Identifier) : 10.1590/S0036-46651984000600006 PMID : 6100138 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651984000600006 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4329 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000830 AC-1984-003 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1984-003.pdfAdobe Acrobat PDF
