Killing of Paracoccidioides brasiliensis conidia by pulmonary macrophages and the effect of cytokines / Luz Elena Cano Restrepo ; R. Arango ; Maria E. Salazar ; Ángela Restrepo Moreno  

Público ISBD Título : Killing of Paracoccidioides brasiliensis conidia by pulmonary macrophages and the effect of cytokines Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; R. Arango, ; Maria E. Salazar, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The ability of conidia, the infectious form of the dimorphic fungus Paracoccidioides brasiliensis, to be killed in vitro by murine pulmonary macrophages was studied. Mice were immunized by intravenous injection of killed conidia, which resulted in cellular immunity demonstrated by delayed type hypersensitivity in vivo and macrophage migration inhibition factor production in vitro. Resident pulmonary macrophages from non-immune mice were able to significantly kill the conidia (28%). Such macrophages treated with supernatants (cytokines) from antigen-stimulated immune mononuclears had a markedly enhanced ability to kill conidia (73%). These results show that activated pulmonary macrophages are potent killers of conidia of P. brasiliensis and that immune mononuclears play a role in activation of macrophages. Activated macrophages may be important for pulmonary defense against the initial stages of infection with this fungus. Mención de responsabilidad : L.E. Cano, R. Arango, M.E. Salazar, E. Brummer, D.A. Stevens & A. Restrepo Referencia : J Med Vet Mycol. 1992;30(2):161-8. DOI (Digital Object Identifier) : 10.1080/02681219280000211 PMID : 1588466 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219280000211 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4365 Killing of Paracoccidioides brasiliensis conidia by pulmonary macrophages and the effect of cytokines [documento electrónico] / Luz Elena Cano Restrepo, ; R. Arango, ; Maria E. Salazar, ; Ángela Restrepo Moreno,  . - 1992. Obra : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The ability of conidia, the infectious form of the dimorphic fungus Paracoccidioides brasiliensis, to be killed in vitro by murine pulmonary macrophages was studied. Mice were immunized by intravenous injection of killed conidia, which resulted in cellular immunity demonstrated by delayed type hypersensitivity in vivo and macrophage migration inhibition factor production in vitro. Resident pulmonary macrophages from non-immune mice were able to significantly kill the conidia (28%). Such macrophages treated with supernatants (cytokines) from antigen-stimulated immune mononuclears had a markedly enhanced ability to kill conidia (73%). These results show that activated pulmonary macrophages are potent killers of conidia of P. brasiliensis and that immune mononuclears play a role in activation of macrophages. Activated macrophages may be important for pulmonary defense against the initial stages of infection with this fungus. Mención de responsabilidad : L.E. Cano, R. Arango, M.E. Salazar, E. Brummer, D.A. Stevens & A. Restrepo Referencia : J Med Vet Mycol. 1992;30(2):161-8. DOI (Digital Object Identifier) : 10.1080/02681219280000211 PMID : 1588466 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219280000211 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4365

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Growth and production of iron chelants by Paracoccidioides brasiliensis mycelial and yeast forms / R. Arango ; Ángela Restrepo Moreno  

Público ISBD Título : Growth and production of iron chelants by Paracoccidioides brasiliensis mycelial and yeast forms Tipo de documento : documento electrónico Autores : R. Arango, ; Ángela Restrepo Moreno, Fecha de publicación : 1988 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The mycelial and yeast forms of the fungus Paracoccidioides brasiliensis were cultured in a chemically defined liquid medium with different iron concentrations and the growth measured spectrophotometrically. The iron binding capacity of culture supernatants was measured by a colorimetric assay. Both the mycelial and yeast forms were able to grow in media containing trace amounts of iron (0·02 mgl-1) but when the iron chelant 1,10 phenantroline was added there was a delay in the initiation of growth of the yeast and almost total inhibition of the mycelium. When iron excess was added to media containing phenantroline, this inhibitory effect was reversed, partially for the mycelial, and completely for the yeast form. For both mycelial and yeast forms, the iron binding capacity of the culture supernatants was greater in media with low iron concentrations. Mención de responsabilidad : R. Arango, A. Restrepo Referencia : J Med Vet Mycol. 1988 Apr;26(2):113-8 DOI (Digital Object Identifier) : 10.1080/02681218880000161 PMID : 3418467 En línea : https://academic.oup.com/mmy/article-abstract/26/2/113/966921 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4345 Growth and production of iron chelants by Paracoccidioides brasiliensis mycelial and yeast forms [documento electrónico] / R. Arango, ; Ángela Restrepo Moreno,  . - 1988. Obra : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The mycelial and yeast forms of the fungus Paracoccidioides brasiliensis were cultured in a chemically defined liquid medium with different iron concentrations and the growth measured spectrophotometrically. The iron binding capacity of culture supernatants was measured by a colorimetric assay. Both the mycelial and yeast forms were able to grow in media containing trace amounts of iron (0·02 mgl-1) but when the iron chelant 1,10 phenantroline was added there was a delay in the initiation of growth of the yeast and almost total inhibition of the mycelium. When iron excess was added to media containing phenantroline, this inhibitory effect was reversed, partially for the mycelial, and completely for the yeast form. For both mycelial and yeast forms, the iron binding capacity of the culture supernatants was greater in media with low iron concentrations. Mención de responsabilidad : R. Arango, A. Restrepo Referencia : J Med Vet Mycol. 1988 Apr;26(2):113-8 DOI (Digital Object Identifier) : 10.1080/02681218880000161 PMID : 3418467 En línea : https://academic.oup.com/mmy/article-abstract/26/2/113/966921 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4345

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