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Activity of two different triazoles in a murine model of paracoccidioidomycosis / Susana Restrepo ; Ángela María Tabares Velásquez ; Ángela Restrepo Moreno
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Título : Activity of two different triazoles in a murine model of paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Activity of two different triazoles in a murine model of paracoccidioidomycosis [documento electrónico] / Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, . - 1992.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000864 AC-1992-003 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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